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Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

Nature (London), 2017-11, Vol.551 (7682), p.653-657

2017

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Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide

Nucleic acids research, 2019-05, Vol.47 (8), p.3828-3835

2019

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Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

PloS one, 2020-12, Vol.15 (12), p.e0243905

2020

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Allosteric modulation of DNA by small molecules

Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (32), p.13175-13179

2009

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A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer

Cancer research (Chicago, Ill.), 2017-05, Vol.77 (9), p.2207-2212

2017

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Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

Proceedings of the National Academy of Sciences - PNAS, 2007-06, Vol.104 (25), p.10418-10423

2007

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Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding

Journal of the American Chemical Society, 2010-10, Vol.132 (41), p.14521-14529

2010

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Design of Sequence-Specific DNA Binding Molecules for DNA Methyltransferase Inhibition

Journal of the American Chemical Society, 2014-03, Vol.136 (9), p.3687-3694

2014

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Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich’s Ataxia Cells

Cell reports (Cambridge), 2016-08, Vol.16 (5), p.1218-1227

2016

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Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Current opinion in structural biology, 2003-06, Vol.13 (3), p.284-299

2003

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Antitumor activity of a pyrrole-imidazole polyamide

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (5), p.1863-1868

2013

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Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (4), p.1023-1028

2012

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Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells

The Journal of biological chemistry, 2012-08, Vol.287 (35), p.29861-29872

2012

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Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide

PloS one, 2015-11, Vol.10 (11), p.e0143161

2015

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Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (39), p.16598-16603

2009

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An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors

Molecular cancer therapeutics, 2016-04, Vol.15 (4), p.608-617

2016

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Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns

Nucleic acids research, 2012-03, Vol.40 (5), p.2345-2356

2012

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RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (44), p.12426-12431

2016

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Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

PloS one, 2018-05, Vol.13 (5), p.e0196803

2018

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A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma

Quarterly reviews of biophysics, 2015-11, Vol.48 (4), p.453-464

2015

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A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity

Molecular cancer research, 2016-03, Vol.14 (3), p.253-266

2016

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Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus

Proceedings of the National Academy of Sciences - PNAS, 2013-02, Vol.110 (8), p.2804-2809

2013

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Microwave Assisted Synthesis of Py-Im Polyamides

Organic letters, 2012-06, Vol.14 (11), p.2774-2777

2012

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Activity of a Py-Im polyamide targeted to the estrogen response element

Molecular cancer therapeutics, 2013-05, Vol.12 (5), p.675-684

2013

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Synthesis of Cyclic Py-Im Polyamide Libraries

Journal of organic chemistry, 2013-01, Vol.78 (1), p.124-133

2013

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Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

Sequence specific suppression of androgen receptor–DNA binding in vivo by a Py-Im polyamide

Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

Allosteric modulation of DNA by small molecules

A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding

Design of Sequence-Specific DNA Binding Molecules for DNA Methyltransferase Inhibition

Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich’s Ataxia Cells

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

Antitumor activity of a pyrrole-imidazole polyamide

Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders

Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors

Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns

RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif

Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma

A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity

Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus

Microwave Assisted Synthesis of Py-Im Polyamides

Activity of a Py-Im polyamide targeted to the estrogen response element

Synthesis of Cyclic Py-Im Polyamide Libraries

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