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CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells

Scientific reports, 2023-02, Vol.13 (1), p.2581-2581, Article 2581

2023

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Metabolic Heterogeneity, Plasticity, and Adaptation to “Glutamine Addiction” in Cancer Cells: The Role of Glutaminase and the GTωA [Glutamine Transaminase—ω-Amidase (Glutaminase II)] Pathway

Biology (Basel, Switzerland), 2023-08, Vol.12 (8), p.1131

2023

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Identification of the 4‑Position of 3‑Alkynyl and 3‑Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P‑450 2A6 Inhibition

Journal of medicinal chemistry, 2018-08, Vol.61 (16), p.7065-7086

2018

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α-Ketoglutaramate—A key metabolite contributing to glutamine addiction in cancer cells

Frontiers in medicine, 2022-11, Vol.13, p.1035335-1035335

2022

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Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.6987-7001

2006

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Liposomal Encapsulated FSC231, a PICK1 Inhibitor, Prevents the Ischemia/Reperfusion-Induced Degradation of GluA2-Containing AMPA Receptors

Pharmaceutics, 2021-04, Vol.13 (5), p.636

2021

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Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis

ASN neuro, 2022, Vol.14, p.175909142211123

2022

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A standardized method for incorporation of drugs into food for use with Drosophila melanogaster

Analytical biochemistry, 2020-06, Vol.599, p.113740-113740, Article 113740

2020

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Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement

Free radical biology & medicine, 2015-01, Vol.78, p.123-134

2015

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An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues

Analytical biochemistry, 2020-02, Vol.591, p.113543-113543, Article 113543

2020

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Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

Cell metabolism, 2018-05, Vol.27 (5), p.1007-1025.e5

2018

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Synthesis of α-Ketoglutaramic acid

Analytical biochemistry, 2020-10, Vol.607, p.113862-113862, Article 113862

2020

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Alpha‐ketoglutarate dehydrogenase complex‐dependent succinylation of proteins in neurons and neuronal cell lines

Journal of neurochemistry, 2015-07, Vol.134 (1), p.86-96

2015

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Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters

Bioorganic & medicinal chemistry letters, 2018-02, Vol.28 (4), p.562-565

2018

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The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites

Biology (Basel, Switzerland), 2017-03, Vol.6 (2), p.24

2017

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The metabolic importance of the glutaminase II pathway in normal and cancerous cells

Analytical biochemistry, 2022-05, Vol.644, p.114083-114083, Article 114083

2022

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Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009-10, Vol.877 (28), p.3434-3441

2009

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The metabolic importance of the overlooked asparaginase II pathway

Analytical biochemistry, 2022-05, Vol.644, p.114084, Article 114084

2022

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Induction of Autophagy in Motor Neurons with Lanthionine Ketenamine Analogs

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Reductions in the mitochondrial enzyme [alpha]-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

Journal of neurochemistry, 2016-12, Vol.139 (5), p.823

2016

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Reductions in the mitochondrial enzyme α‐ketoglutarate dehydrogenase complex in neurodegenerative disease – beneficial or detrimental?

Journal of neurochemistry, 2016-12, Vol.139 (5), p.823-838

2016

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Mild metabolic perturbations alter succinylation of mitochondrial proteins

Journal of neuroscience research, 2017-11, Vol.95 (11), p.2244-2252

2017

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Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human‐induced pluripotent stem cells, neural stem cells, and neurons

Journal of neurochemistry, 2021-03, Vol.156 (6), p.867-879

2021

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The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice

The Journal of pharmacology and experimental therapeutics, 2020-01, Vol.372 (1), p.21

2020

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Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation

Neurobiology of aging, 2012-06, Vol.33 (6), p.1121.e13-1121.e24

2012

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CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells

Metabolic Heterogeneity, Plasticity, and Adaptation to “Glutamine Addiction” in Cancer Cells: The Role of Glutaminase and the GTωA [Glutamine Transaminase—ω-Amidase (Glutaminase II)] Pathway

Identification of the 4‑Position of 3‑Alkynyl and 3‑Heteroaromatic Substituted Pyridine Methanamines as a Key Modification Site Eliciting Increased Potency and Enhanced Selectivity for Cytochrome P‑450 2A6 Inhibition

α-Ketoglutaramate—A key metabolite contributing to glutamine addiction in cancer cells

Synthetic Inhibitors of Cytochrome P-450 2A6: Inhibitory Activity, Difference Spectra, Mechanism of Inhibition, and Protein Cocrystallization

Liposomal Encapsulated FSC231, a PICK1 Inhibitor, Prevents the Ischemia/Reperfusion-Induced Degradation of GluA2-Containing AMPA Receptors

Lanthionine Ketimine Ethyl Ester Accelerates Remyelination in a Mouse Model of Multiple Sclerosis

A standardized method for incorporation of drugs into food for use with Drosophila melanogaster

Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement

An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues

Rewiring of Glutamine Metabolism Is a Bioenergetic Adaptation of Human Cells with Mitochondrial DNA Mutations

Synthesis of α-Ketoglutaramic acid

Alpha‐ketoglutarate dehydrogenase complex‐dependent succinylation of proteins in neurons and neuronal cell lines

Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters

The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites

The metabolic importance of the glutaminase II pathway in normal and cancerous cells

Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism

The metabolic importance of the overlooked asparaginase II pathway

Induction of Autophagy in Motor Neurons with Lanthionine Ketenamine Analogs

Reductions in the mitochondrial enzyme [alpha]-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

Reductions in the mitochondrial enzyme α‐ketoglutarate dehydrogenase complex in neurodegenerative disease – beneficial or detrimental?

Mild metabolic perturbations alter succinylation of mitochondrial proteins

Selective linkage of mitochondrial enzymes to intracellular calcium stores differs between human‐induced pluripotent stem cells, neural stem cells, and neurons

The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice

Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation

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