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Epigenetic regulation of gene expression as an anticancer drug target

Current cancer drug targets, 2011-02, Vol.11 (2), p.199-212

2011

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Comparative bioactivation of the novel anti‐tuberculosis agent PA‐824 in Mycobacteria and a subcellular fraction of human liver

British journal of pharmacology, 2011-01, Vol.162 (1), p.226-236

2011

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A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells

Molecular bioSystems, 2016-03, Vol.12 (3), p.839-849

2016

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DNA minor groove alkylating agents

Current medicinal chemistry, 2001-04, Vol.8 (5), p.533-544

Denny, W A

2001

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Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1380-1397

2000

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Factors associated with appropriate knowledge of the indications for prescribed drugs among community-dwelling older patients with polypharmacy

Age and ageing, 2016-05, Vol.45 (3), p.402-408

2016

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An indoline-derived compound that markedly reduces mouse body weight

International Journal of Obesity, 2013-05, Vol.37 (5), p.685-692

2013

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Acridine derivatives as chemotherapeutic agents

Current medicinal chemistry, 2002-09, Vol.9 (18), p.1655

Denny, William A

2002

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Interaction of Cisplatin and DNA-Targeted 9-Aminoacridine Platinum Complexes with DNA

Biochemistry (Easton), 2000-05, Vol.39 (18), p.5593-5599

2000

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Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model

Journal of antimicrobial chemotherapy, 2017-02, Vol.72 (2), p.421-427

2017

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Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 1999-05, Vol.42 (10), p.1803-1815

1999

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Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f , i j]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.2004-2014

2001

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Structure−Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2383-2393

1999

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Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia

Expert opinion on investigational drugs, 2000-12, Vol.9 (12), p.2889-2901

2000

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Tyrosine Kinase Inhibitors. 18. 6-Substituted 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Soluble, Irreversible Inhibitors of the Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 2001-02, Vol.44 (3), p.429-440

2001

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Prodrug strategies in cancer therapy

European Journal of Medicinal Chemistry, 2001-07, Vol.36 (7), p.577-595

Denny, William A

2001

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Bis(phenazine-1-carboxamides): Structure−Activity Relationships for a New Class of Dual Topoisomerase I/II-Directed Anticancer Drugs

Journal of medicinal chemistry, 2000-04, Vol.43 (7), p.1350-1358

2000

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Synthesis and antitumor activity of some indeno[1,2-b]quinoline-based bis carboxamides

Bioorganic & medicinal chemistry, 2000-05, Vol.8 (5), p.977-984

2000

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Synthesis and Antitumor Properties of N-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors

Journal of medicinal chemistry, 1997-06, Vol.40 (13), p.2040-2046

1997

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Tyrosine Kinase Inhibitors. 11. Soluble Analogues of Pyrrolo- and Pyrazoloquinazolines as Epidermal Growth Factor Receptor Inhibitors: Synthesis, Biological Evaluation, and Modeling of the Mode of Binding

Journal of medicinal chemistry, 1997-05, Vol.40 (10), p.1519-1529

1997

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Tyrosine Kinase Inhibitors. 10. Isomeric 4-[(3-Bromophenyl)amino]pyrido[d]- pyrimidines Are Potent ATP Binding Site Inhibitors of the Tyrosine Kinase Function of the Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 1996-04, Vol.39 (9), p.1823-1835

1996

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Structure−Activity Relationships for the Antileishmanial and Antitrypanosomal Activities of 1‘-Substituted 9-Anilinoacridines

Journal of medicinal chemistry, 1997-08, Vol.40 (16), p.2634-2642

1997

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Tyrosine Kinase Inhibitors. 12. Synthesis and Structure−Activity Relationships for 6-Substituted 4-(Phenylamino)pyrimido[5,4-d]pyrimidines Designed as Inhibitors of the Epidermal Growth Factor Receptor

Journal of medicinal chemistry, 1997-06, Vol.40 (12), p.1820-1826

1997

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Gene-directed enzyme prodrug therapy : quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase

Gene therapy, 1998, Vol.5 (1), p.105-112

1998

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An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours

British journal of cancer, 1997-01, Vol.76 (7), p.894-903

1997

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Epigenetic regulation of gene expression as an anticancer drug target

Comparative bioactivation of the novel anti‐tuberculosis agent PA‐824 in Mycobacteria and a subcellular fraction of human liver

A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells

DNA minor groove alkylating agents

Tyrosine Kinase Inhibitors. 17. Irreversible Inhibitors of the Epidermal Growth Factor Receptor: 4-(Phenylamino)quinazoline- and 4-(Phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides Bearing Additional Solubilizing Functions

Factors associated with appropriate knowledge of the indications for prescribed drugs among community-dwelling older patients with polypharmacy

An indoline-derived compound that markedly reduces mouse body weight

Acridine derivatives as chemotherapeutic agents

Interaction of Cisplatin and DNA-Targeted 9-Aminoacridine Platinum Complexes with DNA

Screening of anti-mycobacterial compounds in a naturally infected zebrafish larvae model

Tyrosine Kinase Inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(Phenylamino)pyrido[d]pyrimidine Acrylamides as Irreversible Inhibitors of the ATP Binding Site of the Epidermal Growth Factor Receptor

Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f , i j]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives

Structure−Activity Relationships for Substituted Bis(acridine-4-carboxamides): A New Class of Anticancer Agents

Tirapazamine: a bioreductive anticancer drug that exploits tumour hypoxia

Tyrosine Kinase Inhibitors. 18. 6-Substituted 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Soluble, Irreversible Inhibitors of the Epidermal Growth Factor Receptor

Prodrug strategies in cancer therapy

Bis(phenazine-1-carboxamides): Structure−Activity Relationships for a New Class of Dual Topoisomerase I/II-Directed Anticancer Drugs

Synthesis and antitumor activity of some indeno[1,2-b]quinoline-based bis carboxamides

Synthesis and Antitumor Properties of N-[2-(Dimethylamino)ethyl]carboxamide Derivatives of Fused Tetracyclic Quinolines and Quinoxalines: A New Class of Putative Topoisomerase Inhibitors

Tyrosine Kinase Inhibitors. 11. Soluble Analogues of Pyrrolo- and Pyrazoloquinazolines as Epidermal Growth Factor Receptor Inhibitors: Synthesis, Biological Evaluation, and Modeling of the Mode of Binding

Tyrosine Kinase Inhibitors. 10. Isomeric 4-[(3-Bromophenyl)amino]pyrido[d]- pyrimidines Are Potent ATP Binding Site Inhibitors of the Tyrosine Kinase Function of the Epidermal Growth Factor Receptor

Structure−Activity Relationships for the Antileishmanial and Antitrypanosomal Activities of 1‘-Substituted 9-Anilinoacridines

Tyrosine Kinase Inhibitors. 12. Synthesis and Structure−Activity Relationships for 6-Substituted 4-(Phenylamino)pyrimido[5,4-d]pyrimidines Designed as Inhibitors of the Epidermal Growth Factor Receptor

Gene-directed enzyme prodrug therapy : quantitative bystander cytotoxicity and DNA damage induced by CB1954 in cells expressing bacterial nitroreductase

An experimental and mathematical model for the extravascular transport of a DNA intercalator in tumours

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