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Beneficial metabolic effects of CB1R anti-sense oligonucleotide treatment in diet-induced obese AKR/J mice

PloS one, 2012-08, Vol.7 (8), p.e42134

2012

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Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1)

Journal of cellular biochemistry, 2003-10, Vol.90 (2), p.339-346

2003

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Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice

Diabetes (New York, N.Y.), 2004-02, Vol.53 (2), p.410-417

2004

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Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2456-2460

2009

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2,5-Disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-11, Vol.13 (22), p.4031-4034

2003

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Next-generation spirobenzazepines : Identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (23), p.6623-6628

2007

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Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.3134-3141

2011

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Design, Synthesis, and Biological Evaluation of (2R,αS)-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inhibitor

Journal of medicinal chemistry, 2009-03, Vol.52 (6), p.1768-1772

2009

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Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (4), p.1432-1435

2010

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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs

Bioorganic & medicinal chemistry letters, 2014-03, Vol.24 (5), p.1437-1441

2014

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3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3

Bioorganic & medicinal chemistry letters, 2004-06, Vol.14 (12), p.3245-3250

2004

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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6773-6776

2013

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Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats

American journal of physiology: endocrinology and metabolism, 2005-03, Vol.288 (3), p.E617-E624

2005

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Torcetrapib Produces Endothelial Dysfunction Independent of Cholesteryl Ester Transfer Protein Inhibition

Journal of cardiovascular pharmacology, 2010-05, Vol.55 (5), p.459-468

2010

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Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors

Bioorganic & medicinal chemistry letters, 2005-11, Vol.15 (21), p.4790-4793

2005

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Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A

Biochemical and biophysical research communications, 2006-06, Vol.345 (1), p.29-37

2006

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Synthesis and Discovery of Macrocyclic Polyoxygenated Bis-7-azaindolylmaleimides as a Novel Series of Potent and Highly Selective Glycogen Synthase Kinase-3β Inhibitors

Journal of medicinal chemistry, 2003-09, Vol.46 (19), p.4021-4031

2003

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Novel Indolylindazolylmaleimides as Inhibitors of Protein Kinase C-β: Synthesis, Biological Activity, and Cardiovascular Safety

Journal of medicinal chemistry, 2005-03, Vol.48 (6), p.1725-1728

2005

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Human epidermoid A431 cells express functional nicotinic Acid receptor HM74a

Molecular and cellular biochemistry, 2007-01, Vol.294 (1-2), p.243-248

2007

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Nuclear receptors as potential targets for modulating reverse cholesterol transport

Current topics in medicinal chemistry, 2005-01, Vol.5 (3), p.265-282

2005

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Benzoxazinones as PPARγ Agonists. 2. SAR of the Amide Substituent and In Vivo Results in a Type 2 Diabetes Model

Journal of medicinal chemistry, 2004-01, Vol.47 (1), p.196-209

2004

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Phase 0 study of the inhibition of cholesteryl ester transfer protein activity by JNJ-28545595 in plasma from normolipidemic and dyslipidemic humans

International journal of clinical pharmacology and therapeutics, 2012-08, Vol.50 (8), p.584-594

2012

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Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARα agonists

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6773-6778

2007

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Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1696-1701

2006

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Heteroaryl- O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (23), p.5202-5206

2005

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Beneficial metabolic effects of CB1R anti-sense oligonucleotide treatment in diet-induced obese AKR/J mice

Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1)

Reduction in Glucagon Receptor Expression by an Antisense Oligonucleotide Ameliorates Diabetic Syndrome in db/db Mice

Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform

2,5-Disubstituted 3,4-dihydro-2H-benzo[b][1,4]thiazepines as potent and selective V2 arginine vasopressin receptor antagonists

Next-generation spirobenzazepines : Identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Design, Synthesis, and Biological Evaluation of (2R,αS)-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inhibitor

Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs

Topiramate is an insulin-sensitizing compound in vivo with direct effects on adipocytes in female ZDF rats

Torcetrapib Produces Endothelial Dysfunction Independent of Cholesteryl Ester Transfer Protein Inhibition

Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors

Enhancement of arachidonic acid signaling pathway by nicotinic acid receptor HM74A

Synthesis and Discovery of Macrocyclic Polyoxygenated Bis-7-azaindolylmaleimides as a Novel Series of Potent and Highly Selective Glycogen Synthase Kinase-3β Inhibitors

Novel Indolylindazolylmaleimides as Inhibitors of Protein Kinase C-β: Synthesis, Biological Activity, and Cardiovascular Safety

Human epidermoid A431 cells express functional nicotinic Acid receptor HM74a

Nuclear receptors as potential targets for modulating reverse cholesterol transport

Benzoxazinones as PPARγ Agonists. 2. SAR of the Amide Substituent and In Vivo Results in a Type 2 Diabetes Model

Phase 0 study of the inhibition of cholesteryl ester transfer protein activity by JNJ-28545595 in plasma from normolipidemic and dyslipidemic humans

Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARα agonists

Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2

Heteroaryl- O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1

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