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The liver: conductor of systemic iron balance

Blood, 2014-01, Vol.123 (2), p.168-176

2014

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Lack of the bone morphogenetic protein BMP6 induces massive iron overload

Nature genetics, 2009-04, Vol.41 (4), p.478-481

2009

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Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)‐SMAD signaling pathway in mice

Hepatology (Baltimore, Md.), 2011-07, Vol.54 (1), p.273-284

2011

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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

Blood, 2008-08, Vol.112 (4), p.1503-1509

2008

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Differing impact of the deletion of hemochromatosis‐associated molecules HFE and transferrin receptor‐2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

Hepatology (Baltimore, Md.), 2016-01, Vol.63 (1), p.126-137

2016

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Iron Regulation of Hepcidin Despite Attenuated Smad1,5,8 Signaling in Mice Without Transferrin Receptor 2 or Hfe

Gastroenterology (New York, N.Y. 1943), 2011-11, Vol.141 (5), p.1907-1914

2011

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LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Haematologica (Roma), 2020-08, Vol.105 (8), p.e385-e388

2020

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Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

Blood, 2011-07, Vol.118 (3), p.747-756

2011

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Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR

Haematologica (Roma), 2021-04, Vol.106 (4), p.1202-1206

2021

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BMP6 Treatment Compensates for the Molecular Defect and Ameliorates Hemochromatosis in Hfe Knockout Mice

Gastroenterology (New York, N.Y. 1943), 2010-11, Vol.139 (5), p.1721-1729

2010

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Iron overload induces BMP6 expression in the liver but not in the duodenum

Haematologica (Roma), 2011-02, Vol.96 (2), p.199-203

2011

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Inflammation regulates TMPRSS6 expression via STAT5

PloS one, 2013-12, Vol.8 (12), p.e82127

2013

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A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum

Haematologica (Roma), 2013-02, Vol.98 (2), p.296-304

2013

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Homologous Recombination is Involved in the Repair Response of Mammalian Cells to Low Doses of Tritium

Radiation research, 2008-08, Vol.170 (2), p.172-183

2008

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Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge

Blood, 2017-11, Vol.130 (21), p.2339-2343

2017

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Regulators of hepcidin expression

Vitamins and hormones, 2019, Vol.110, p.101-129

2019

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Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

Blood, 2016-05, Vol.127 (19), p.2327-2336

2016

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Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B

Blood, 2017-01, Vol.129 (4), p.533-536

2017

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Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge: Combined BMP6/HJV deficiency, iron and inflammation

Blood, 2017-10

2017

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Deletion of BMP6 Worsens the Phenotype of Hemojuvelin-Deficient Mice and Attenuates Hepcidin Levels Reached after LPS Stimulation

Blood, 2017-12, Vol.130, p.226-226

2017

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The role of TMPRSS6/matriptase-2 in iron regulation and anemia

Frontiers in pharmacology, 2014-05, Vol.5, p.114-114

2014

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MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription

The Journal of biological chemistry, 2014-08, Vol.289 (34), p.23796-23808

2014

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Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

Blood, 2019-11, Vol.134 (Supplement_1), p.3532-3532

2019

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BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression

Blood, 2009-09, Vol.114 (12), p.2515-2520

2009

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The liver: conductor of systemic iron balance

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)‐SMAD signaling pathway in mice

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

Differing impact of the deletion of hemochromatosis‐associated molecules HFE and transferrin receptor‐2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

Iron Regulation of Hepcidin Despite Attenuated Smad1,5,8 Signaling in Mice Without Transferrin Receptor 2 or Hfe

LJ000328, a novel ALK2/3 kinase inhibitor, represses hepcidin and significantly improves the phenotype of IRIDA

Regulation of TMPRSS6 by BMP6 and iron in human cells and mice

Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR

BMP6 Treatment Compensates for the Molecular Defect and Ameliorates Hemochromatosis in Hfe Knockout Mice

Iron overload induces BMP6 expression in the liver but not in the duodenum

Inflammation regulates TMPRSS6 expression via STAT5

A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum

Homologous Recombination is Involved in the Repair Response of Mammalian Cells to Low Doses of Tritium

Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge

Regulators of hepcidin expression

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B

Deletion of BMP6 worsens the phenotype of HJV-deficient mice and attenuates hepcidin levels reached after LPS challenge: Combined BMP6/HJV deficiency, iron and inflammation

Deletion of BMP6 Worsens the Phenotype of Hemojuvelin-Deficient Mice and Attenuates Hepcidin Levels Reached after LPS Stimulation

The role of TMPRSS6/matriptase-2 in iron regulation and anemia

MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription

Generation and Characterisation of KY1066, a Fully Human Antibody Targeting the Enzymatic Activity of Matriptase-2 for the Treatment of Iron Overload in Beta Thalassemia

BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression

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