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The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

PloS one, 2017-01, Vol.12 (1), p.e0169648-e0169648

2017

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Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

PloS one, 2022-04, Vol.17 (4), p.e0262516-e0262516

2022

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Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism

Journal of hepatology, 2018-05, Vol.68 (5), p.922-931

2018

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Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by Phosphorylation

Journal of virology, 2016-06, Vol.90 (12), p.5830-5844

2016

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Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus

Antimicrobial Agents and Chemotherapy, 2006-07, Vol.50 (7), p.2471-2477

2006

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Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Hepatology (Baltimore, Md.), 2021-01, Vol.73 (1), p.53-67

2021

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Targeted Long-Read Sequencing Reveals Comprehensive Architecture, Burden, and Transcriptional Signatures from Hepatitis B Virus-Associated Integrations and Translocations in Hepatocellular Carcinoma Cell Lines

Journal of virology, 2021-09, Vol.95 (19), p.e0029921-e0029921

2021

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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10188-10203

2020

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A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook

Nature reviews. Gastroenterology & hepatology, 2022-11, Vol.19 (11), p.727-745

2022

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Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells

Journal of hepatology, 2018-05, Vol.68 (5), p.912-921

2018

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Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo

Molecular therapy, 2022-09, Vol.30 (9), p.2909-2922

2022

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Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy

Gastroenterology (New York, N.Y. 1943), 2004-06, Vol.126 (7), p.1750-1758

2004

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Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals

Proceedings of the National Academy of Sciences - PNAS, 2011-06, Vol.108 (25), p.10290-10295

2011

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Novel Hepatitis C Virus Reporter Replicon Cell Lines Enable Efficient Antiviral Screening against Genotype 1a

Antimicrobial Agents and Chemotherapy, 2010-08, Vol.54 (8), p.3099-3106

2010

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New therapeutic targets and drugs for the treatment of chronic hepatitis B

Seminars in liver disease, 2013-05, Vol.33 (2), p.130-137

2013

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Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection

Antimicrobial agents and chemotherapy, 2023-01, Vol.67 (1), p.e0134822

2023

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Characterization of Hepatitis B Precore/Core-Related Antigens

Journal of virology, 2021-01, Vol.95 (3)

2021

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In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents

Antiviral therapy, 2007-01, Vol.12 (3), p.355-362

2007

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Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (7), p.2629-2634

2012

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Molecular virology of chronic hepatitis B and C: Parallels, contrasts and impact on drug development and treatment outcome

Antiviral research, 2013-07, Vol.99 (1), p.34-48

Delaney, William E.

2013

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Microwave measurement of giant unilamellar vesicles in aqueous solution

Scientific reports, 2018-01, Vol.8 (1), p.497-497, Article 497

2018

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Preclinical Characterization of the Novel Hepatitis C Virus NS3 Protease Inhibitor GS-9451

Antimicrobial Agents and Chemotherapy, 2014-02, Vol.58 (2), p.647-653

2014

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Development of a digital droplet PCR assay to measure HBV DNA in patients receiving long-term TDF treatment

Journal of virological methods, 2017-11, Vol.249, p.189-193

2017

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Rapid and Reliable Protein-Free HBV DNA Extraction and Sensitive Branched DNA Southern Blot Assay

Methods in molecular biology (Clifton, N.J.), 2024, Vol.2837, p.113

2024

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Establishment of infectious genotype 4 cell culture-derived hepatitis C virus

Journal of general virology, 2020-02, Vol.101 (2), p.188-197

2020

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The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection

Ongoing viral replication and production of infectious virus in patients with chronic hepatitis B virus suppressed below the limit of quantitation on long-term nucleos(t)ide therapy

Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanism

Cell-Free Hepatitis B Virus Capsid Assembly Dependent on the Core Protein C-Terminal Domain and Regulated by Phosphorylation

Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus

Toll‐Like Receptor 8 Agonist GS‐9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Targeted Long-Read Sequencing Reveals Comprehensive Architecture, Burden, and Transcriptional Signatures from Hepatitis B Virus-Associated Integrations and Translocations in Hepatocellular Carcinoma Cell Lines

Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B

A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook

Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells

Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo

Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy

Preexisting drug-resistance mutations reveal unique barriers to resistance for distinct antivirals

Novel Hepatitis C Virus Reporter Replicon Cell Lines Enable Efficient Antiviral Screening against Genotype 1a

New therapeutic targets and drugs for the treatment of chronic hepatitis B

Characterization of a Novel Capsid Assembly Modulator for the Treatment of Chronic Hepatitis B Virus Infection

Characterization of Hepatitis B Precore/Core-Related Antigens

In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents

Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease

Molecular virology of chronic hepatitis B and C: Parallels, contrasts and impact on drug development and treatment outcome

Microwave measurement of giant unilamellar vesicles in aqueous solution

Preclinical Characterization of the Novel Hepatitis C Virus NS3 Protease Inhibitor GS-9451

Development of a digital droplet PCR assay to measure HBV DNA in patients receiving long-term TDF treatment

Rapid and Reliable Protein-Free HBV DNA Extraction and Sensitive Branched DNA Southern Blot Assay

Establishment of infectious genotype 4 cell culture-derived hepatitis C virus

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