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GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

Journal of endocrinology, 2009-05, Vol.201 (2), p.219-230

2009

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Increased seizure threshold and severity in young transgenic CRND8 mice

Neuroscience letters, 2004-09, Vol.367 (2), p.164-167

2004

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In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Interdisciplinary perspectives on infectious diseases, 2013, Vol.2013 (2013), p.1-14

2013

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Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (23), p.5836-5841

2016

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In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

International journal of alzheimer's disease, 2013, Vol.2013, p.1-14

2013

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Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.844-849

2013

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The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): Comparison of efficacy and side effects across rodent species

European journal of pharmacology, 2011-07, Vol.661 (1), p.63-71

2011

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Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors

Bioorganic & medicinal chemistry, 2008-01, Vol.18 (1), p.215-219

2008

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Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice

European journal of pharmacology, 2006-03, Vol.535 (1), p.182-191

2006

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Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

ACS medicinal chemistry letters, 2012-11, Vol.3 (11), p.892-896

2012

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Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

Behavioural pharmacology, 2007-03, Vol.18 (2), p.89-102

2007

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Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

Brain research, 2003-12, Vol.994 (1), p.99-106

2003

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Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8-APPswe/ind mice

Alzheimer's & dementia, 2010-07, Vol.6 (4), p.S539-S539

2010

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Structure activity relationship studies of tricyclic bispyran sulfone [gamma]-secretase inhibitors

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.844-849

2013

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The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]oct a ne-3-carboxamide (SCH 655842): Comparison of efficacy and side effects across rodent species

European journal of pharmacology, 2011-07, Vol.661 (1-3), p.63-71

2011

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P3‐299: Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8‐APP swe/ind mice

Alzheimer's & dementia, 2010-07, Vol.6 (4S_Part_17)

2010

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P3‐299: Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8‐APPswe/ind mice

Alzheimer's & dementia, 2010-07, Vol.6, p.S539-S539

2010

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The discriminative stimulus effect of MK-801 in ketamine-trained rats

Pharmacology, biochemistry and behavior, 1991, Vol.38 (1), p.211-213

1991

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An in vivo alpha-2 assay reversal of opioid-induced muscular rigidity and neuroleptic-induced ptosis

Journal of pharmacological and toxicological methods, 1992-03, Vol.27 (1), p.45-50

1992

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Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial

The lancet oncology, 2017-05, Vol.18 (5), p.611-622

2017

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Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types

PLoS genetics, 2013-04, Vol.9 (4), p.e1003464-e1003464

2013

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Cabozantinib for the Management of Metastatic Clear Cell Renal Cell Carcinoma

Journal of kidney cancer and VHL, 2018-01, Vol.5 (4), p.1-5

2018

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Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

Nature genetics, 2014-04, Vol.46 (4), p.385-388

2014

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GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis

Increased seizure threshold and severity in young transgenic CRND8 mice

In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Design and synthesis of water soluble β-aminosulfone analogues of SCH 900229 as γ-secretase inhibitors

In Vivo Characterization of a Novel -Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects

Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octane-3-carboxamide (SCH 655842): Comparison of efficacy and side effects across rodent species

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors

Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

Automated evaluation of sensitivity to foot shock in mice: inbred strain differences and pharmacological validation

Increased auditory startle response and reduced prepulse inhibition of startle in transgenic mice expressing a double mutant form of amyloid precursor protein

Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8-APPswe/ind mice

Structure activity relationship studies of tricyclic bispyran sulfone [gamma]-secretase inhibitors

The anxiolytic-like profile of the nociceptin receptor agonist, endo-8-[bis(2-chlorophenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]oct a ne-3-carboxamide (SCH 655842): Comparison of efficacy and side effects across rodent species

P3‐299: Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8‐APP swe/ind mice

P3‐299: Chronic administration of a novel BACE inhibitor reduced brain Aβ levels and mature plaques and modestly improved cognition in transgenic CRND8‐APPswe/ind mice

The discriminative stimulus effect of MK-801 in ketamine-trained rats

An in vivo alpha-2 assay reversal of opioid-induced muscular rigidity and neuroleptic-induced ptosis

Ipilimumab 10 mg/kg versus ipilimumab 3 mg/kg in patients with unresectable or metastatic melanoma: a randomised, double-blind, multicentre, phase 3 trial

Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types

A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer

Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial

Cabozantinib for the Management of Metastatic Clear Cell Renal Cell Carcinoma

Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability

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