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Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1654-1657

2009

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G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

Current topics in medicinal chemistry, 2011-08, Vol.11 (15), p.1902-1924

2011

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Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

Journal of medicinal chemistry, 2003-07, Vol.46 (15), p.3354-3370

2003

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Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

Nature, 2004-11, Vol.432 (7013), p.118-122

2004

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Cytotoxic Effects of Combination of Oxidosqualene Cyclase Inhibitors with Atorvastatin in Human Cancer Cells

Journal of medicinal chemistry, 2012-06, Vol.55 (11), p.4990-5002

2012

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2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)

ChemMedChem, 2013-04, Vol.8 (4), p.569-576

2013

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Oxidosqualene Cyclase (OSC) Inhibitors for the Treatment of Dyslipidemia

Chimia, 2005-03, Vol.59 (3), p.72

2005

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Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4627-4632

2013

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Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: A model for the development of novel antiparasitic agents

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.718-723

2009

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Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5426-5430

2010

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Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

Journal of lipid research, 1997-02, Vol.38 (2), p.373-390

1997

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Cover Picture: 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5) (ChemMedChem 4/2013)

ChemMedChem, 2013-04, Vol.8 (4), p.533-533

2013

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Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

Journal of medicinal chemistry, 2003-05, Vol.46 (11), p.2083-2092

2003

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Endothelin-Converting Enzyme-1 Inhibition and Growth of Human Glioblastoma Cells

Journal of medicinal chemistry, 2005-01, Vol.48 (2), p.483-498

2005

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Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRα and β

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (19), p.5231-5237

2006

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A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

Arteriosclerosis, thrombosis, and vascular biology, 2005-12, Vol.25 (12), p.2608-2614

2005

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Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

Hypertension (Dallas, Tex. 1979), 2002-12, Vol.40 (6), p.840-846

2002

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Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (19), p.5231-5237

2006

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Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors

Bioorganic & medicinal chemistry letters, 2002-07, Vol.12 (13), p.1727-1730

2002

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Stereocontrolled total synthesis of the unnatural enantiomers of castanospermine and 1-epi-castanospermine

Journal of organic chemistry, 1992-05, Vol.57 (11), p.3194-3202

1992

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Stereocontrolled formation of Polysubstitued tetrahydorfurans by debenzylating cycloetherification

Tetrahedron letters, 1992-06, Vol.33 (25), p.3607-3610

1992

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Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator

G protein-coupled receptor transmembrane binding pockets and their applications in GPCR research and drug discovery: a survey

Synthesis and Structure−Activity Studies of Novel Orally Active Non-Terpenoic 2,3-Oxidosqualene Cyclase Inhibitors

Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

Cytotoxic Effects of Combination of Oxidosqualene Cyclase Inhibitors with Atorvastatin in Human Cancer Cells

2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5)

Oxidosqualene Cyclase (OSC) Inhibitors for the Treatment of Dyslipidemia

Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists

Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: A model for the development of novel antiparasitic agents

Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: Optimization of in vitro activity

Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

Cover Picture: 2-Phenoxy-nicotinamides are Potent Agonists at the Bile Acid Receptor GPBAR1 (TGR5) (ChemMedChem 4/2013)

Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene−Hopene Cyclase

Endothelin-Converting Enzyme-1 Inhibition and Growth of Human Glioblastoma Cells

Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRα and β

A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content

Endothelin-Converting Enzyme Inhibition Ameliorates Angiotensin II–Induced Cardiac Damage

Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta

Synthesis of triazole-Tethered pyrrolidine libraries: novel ECE inhibitors

Stereocontrolled total synthesis of the unnatural enantiomers of castanospermine and 1-epi-castanospermine

Stereocontrolled formation of Polysubstitued tetrahydorfurans by debenzylating cycloetherification

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