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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.761-764

2005

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Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

Biochemical journal, 2005-01, Vol.385 (Pt 2), p.399-408

2005

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The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4216-4224

2001

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PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites

Drug metabolism and disposition, 2001-03, Vol.29 (3), p.313

2001

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Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

Molecular cancer therapeutics, 2005-02, Vol.4 (2), p.271-279

2005

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Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (4), p.905-909

2005

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Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

Molecular and Cellular Biology, 1991-11, Vol.11 (11), p.5792-5799

1991

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A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

Nature medicine, 2000-11, Vol.6 (11), p.1248-1252

2000

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Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha

Molecular and Cellular Biology, 1988-08, Vol.8 (8), p.2999-3007

1988

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Synthesis and biological evaluation of unnatural canthine alkaloids

Tetrahedron letters, 2005-04, Vol.46 (16), p.2779-2782

2005

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Substitution of lysine for arginine at position 42 of human transforming growth factor-alpha eliminates biological activity without changing internal disulfide bonds

Molecular and Cellular Biology, 1989-09, Vol.9 (9), p.4083-4086

1989

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Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins

Molecular and Cellular Biology, 1989-07, Vol.9 (7), p.2860-2867

1989

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ras-related gene sequences identified and isolated from Saccharomyces cerevisiae

Nature (London), 1983-01, Vol.306 (5944), p.707-709

1983

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Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts

Journal of Virology, 1993-02, Vol.67 (2), p.716-725

1993

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Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein

The Journal of biological chemistry, 1990-08, Vol.265 (22), p.12782-12785

1990

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Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity

Journal of medicinal chemistry, 2002-10, Vol.45 (21), p.4706-4715

2002

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Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product

Molecular and Cellular Biology, 1992-05, Vol.12 (5), p.1905-1914

1992

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Tumors secreting human TNF/cachectin induce cachexia in mice

Cell, 1987-08, Vol.50 (4), p.555-563

1987

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Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals

Molecular and Cellular Biology, 1984-01, Vol.4 (1), p.23-29

1984

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A Prostate-specific Antigen (PSA)-activated Vinblastine Prodrug Selectively Kills PSA-secreting Cells in Vivo

Molecular cancer therapeutics, 2002-05, Vol.1 (7), p.451

2002

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Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Nature (London), 1991-07, Vol.352 (6332), p.251-254

1991

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Characterization of the retinoblastoma binding proteins RBP1 and RBP2

Oncogene, 1993-11, Vol.8 (11), p.3149-3156

1993

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Expression and characterization of ras mRNAs from Saccharomyces cerevisiae

Molecular and Cellular Biology, 1984-11, Vol.4 (11), p.2298-2305

1984

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Characterization of functional HPV-16 E7 protein produced in Escherichia coli

The Journal of biological chemistry, 1992-04, Vol.267 (10), p.6910-6915

1992

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Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product

Journal of general virology, 1993-01, Vol.74 (1), p.115-119

1993

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Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy

PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites

Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides

A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha

Synthesis and biological evaluation of unnatural canthine alkaloids

Substitution of lysine for arginine at position 42 of human transforming growth factor-alpha eliminates biological activity without changing internal disulfide bonds

Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins

ras-related gene sequences identified and isolated from Saccharomyces cerevisiae

Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts

Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein

Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity

Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product

Tumors secreting human TNF/cachectin induce cachexia in mice

Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals

A Prostate-specific Antigen (PSA)-activated Vinblastine Prodrug Selectively Kills PSA-secreting Cells in Vivo

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Characterization of the retinoblastoma binding proteins RBP1 and RBP2

Expression and characterization of ras mRNAs from Saccharomyces cerevisiae

Characterization of functional HPV-16 E7 protein produced in Escherichia coli

Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product

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