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Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2295-2314

1999

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Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

Science (American Association for the Advancement of Science), 1999-06, Vol.284 (5420), p.1664-1666

1999

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Biology of TACE inhibition

Annals of the rheumatic diseases, 2001-11, Vol.60 (suppl 3), p.iii25-iii32

2001

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Photochemically Enhanced Binding of Small Molecules to the Tumor Necrosis Factor Receptor-1 Inhibits the Binding of TNF-α

Proceedings of the National Academy of Sciences - PNAS, 2001-10, Vol.98 (21), p.11879-11884

2001

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Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Journal of medicinal chemistry, 2001-08, Vol.44 (16), p.2636-2660

2001

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Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3351-3354

2001

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Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α Production

Journal of medicinal chemistry, 1998-05, Vol.41 (11), p.1745-1748

1998

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Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

The Journal of biological chemistry, 1999-08, Vol.274 (33), p.23443-23450

1999

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Intramolecular O-Arylation of Phenols with Phenylboronic Acids: Application to the Synthesis of Macrocyclic Metalloproteinase Inhibitors

Organic letters, 2001-04, Vol.3 (7), p.1029-1032

2001

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Macrocyclic Amino Carboxylates as Selective MMP-8 Inhibitors

Journal of medicinal chemistry, 1998-05, Vol.41 (11), p.1749-1751

1998

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Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

The Journal of biological chemistry, 1999-03, Vol.274 (10), p.6594-6601

1999

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α-Ketoamides, α-ketoesters and α-diketones as HCV NS3 protease inhibitors

Bioorganic & medicinal chemistry letters, 2000-04, Vol.10 (8), p.711-713

2000

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Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Bioorganic & medicinal chemistry letters, 1998-04, Vol.8 (7), p.837-842

1998

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Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production

Bioorganic & medicinal chemistry letters, 1999-05, Vol.9 (9), p.1279-1284

1999

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Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase

Osteoarthritis and cartilage, 1998-05, Vol.6 (3), p.214-228

1998

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1-Aminocyclopropaneboronic Acid: Synthesis and Incorporation into an Inhibitor of Hepatitis C Virus NS3 Protease

Organic letters, 2000-10, Vol.2 (20), p.3095-3097

2000

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Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors

Journal of medicinal chemistry, 2001-10, Vol.44 (21), p.3347-3350

2001

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The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes

The Journal of immunology (1950), 1997-11, Vol.159 (9), p.4524

1997

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Complementarity of Combinatorial Chemistry and Structure-Based Ligand Design: Application to the Discovery of Novel Inhibitors of Matrix Metalloproteinases

Journal of the American Chemical Society, 1996-10, Vol.118 (42), p.10337-10338

1996

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Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation

Annals of the New York Academy of Sciences, 1999-06, Vol.878 (1), p.92-107

1999

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Catalytic Transformations via C-H Activation 1: Reference Library 2015/3a

2016

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Heteroaryl-Fused 2-Phenylisothiazolone Inhibitors of Cartilage Breakdown

Journal of medicinal chemistry, 1994-09, Vol.37 (19), p.3071-3078

1994

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Catalytic Transformations via C-H Activation: Reference Library 2015/3b

2015

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Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (18), p.2561

2001

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Cleavage of Native Cartilage Aggrecan by Neutrophil Collagenase (MMP-8) Is Distinct from Endogenous Cleavage by Aggrecanase

The Journal of biological chemistry, 1997-04, Vol.272 (14), p.9294-9299

1997

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Therapeutic Potential and Strategies for Inhibiting Tumor Necrosis Factor-α

Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

Biology of TACE inhibition

Photochemically Enhanced Binding of Small Molecules to the Tumor Necrosis Factor Receptor-1 Inhibits the Binding of TNF-α

Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α Production

Cloning and Characterization of ADAMTS11 , an Aggrecanase from the ADAMTS Family

Intramolecular O-Arylation of Phenols with Phenylboronic Acids: Application to the Synthesis of Macrocyclic Metalloproteinase Inhibitors

Macrocyclic Amino Carboxylates as Selective MMP-8 Inhibitors

Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

α-Ketoamides, α-ketoesters and α-diketones as HCV NS3 protease inhibitors

Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases

Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production

Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase

1-Aminocyclopropaneboronic Acid: Synthesis and Incorporation into an Inhibitor of Hepatitis C Virus NS3 Protease

Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors

The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes

Complementarity of Combinatorial Chemistry and Structure-Based Ligand Design: Application to the Discovery of Novel Inhibitors of Matrix Metalloproteinases

Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation

Catalytic Transformations via C-H Activation 1: Reference Library 2015/3a

Heteroaryl-Fused 2-Phenylisothiazolone Inhibitors of Cartilage Breakdown

Catalytic Transformations via C-H Activation: Reference Library 2015/3b

Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase

Cleavage of Native Cartilage Aggrecan by Neutrophil Collagenase (MMP-8) Is Distinct from Endogenous Cleavage by Aggrecanase

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