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Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present

Biomolecules (Basel, Switzerland), 2022-06, Vol.12 (6), p.815

2022

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Definition of fatty acid transport protein-2 (FATP2) structure facilitates identification of small molecule inhibitors for the treatment of diabetic complications

International journal of biological macromolecules, 2023-07, Vol.244, p.125328-125328, Article 125328

2023

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Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (51), p.18225-18230

2014

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Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Journal of enzyme inhibition and medicinal chemistry, 2019-01, Vol.34 (1), p.438-450

2019

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Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.666-680

2018

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Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid–Base Catalysis

ACS catalysis, 2021-05, Vol.11 (9), p.5873-5884

2021

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Nucleoside Analogue Triphosphates Allosterically Regulate Human Ribonucleotide Reductase and Identify Chemical Determinants That Drive Substrate Specificity

Biochemistry (Easton), 2016-10, Vol.55 (41), p.5884-5896

2016

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Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

Nature structural & molecular biology, 2011-03, Vol.18 (3), p.316

2011

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Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme

FEBS letters, 2016-06, Vol.590 (12), p.1704-1712

2016

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The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase

Progress in Molecular Biology and Translational Science, 2013, Vol.117, p.389-410

2013

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Molecular basis for passive immunotherapy of Alzheimer's disease

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (40), p.15659-15664

2007

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Neutron Diffraction Studies of Escherichia coli Dihydrofolate Reductase Complexed with Methotrexate

Proceedings of the National Academy of Sciences - PNAS, 2006-12, Vol.103 (49), p.18493-18498

2006

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Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase

PloS one, 2011-02, Vol.6 (2), p.e17055-e17055

2011

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On the determinants of amide backbone exchange in proteins: a neutron crystallographic comparative study

Acta crystallographica. Section D, Biological crystallography., 2008-07, Vol.64 (7), p.764-783

2008

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Structures of Eukaryotic Ribonucleotide Reductase I Provide Insights into dNTP Regulation

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (11), p.4022-4027

2006

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X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design

Journal of structural biology, 2009-05, Vol.166 (2), p.162

2009

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Structures of Eukaryotic Ribonucleotide Reductase I Define Gemcitabine Diphosphate Binding and Subunit Assembly

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (11), p.4028-4033

2006

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Crystal Structure of the Anthrax Drug Target, Bacillus anthracis Dihydrofolate Reductase

Journal of medicinal chemistry, 2007-09, Vol.50 (18), p.4374-4381

2007

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Pro-1 of Macrophage Migration Inhibitory Factor Functions as a Catalytic Base in the Phenylpyruvate Tautomerase Activity

Biochemistry (Easton), 1999-06, Vol.38 (22), p.7346-7354

1999

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Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy

Pharmaceuticals, 2011-10, Vol.4 (10), p.1328-1354

2011

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Crystal Structure of Chemically Synthesized [N33A] Stromal Cell-Derived Factor 1α , a Potent Ligand for the HIV-1 ``Fusin" Coreceptor

Proceedings of the National Academy of Sciences - PNAS, 1998-06, Vol.95 (12), p.6941-6946

1998

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Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

Journal of neuroinflammation, 2010-09, Vol.7 (1), p.57-57, Article 57

2010

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X-ray structure of the ternary MTX·NADPH complex of the anthrax dihydrofolate reductase: A pharmacophore for dual-site inhibitor design

Journal of structural biology, 2009-05, Vol.166 (2), p.162-171

2009

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Towards understanding the structure-function relationship of human amyloid disease

Current drug targets, 2004-02, Vol.5 (2), p.159

2004

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Protein structures by spallation neutron crystallography

Journal of synchrotron radiation, 2008-05, Vol.15 (3), p.215-218

2008

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Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present

Definition of fatty acid transport protein-2 (FATP2) structure facilitates identification of small molecule inhibitors for the treatment of diabetic complications

Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography

Structure-guided design of anti-cancer ribonucleotide reductase inhibitors

Structure-Guided Synthesis and Mechanistic Studies Reveal Sweetspots on Naphthyl Salicyl Hydrazone Scaffold as Non-Nucleosidic Competitive, Reversible Inhibitors of Human Ribonucleotide Reductase

Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid–Base Catalysis

Nucleoside Analogue Triphosphates Allosterically Regulate Human Ribonucleotide Reductase and Identify Chemical Determinants That Drive Substrate Specificity

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme

The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase

Molecular basis for passive immunotherapy of Alzheimer's disease

Neutron Diffraction Studies of Escherichia coli Dihydrofolate Reductase Complexed with Methotrexate

Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase

On the determinants of amide backbone exchange in proteins: a neutron crystallographic comparative study

Structures of Eukaryotic Ribonucleotide Reductase I Provide Insights into dNTP Regulation

X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design

Structures of Eukaryotic Ribonucleotide Reductase I Define Gemcitabine Diphosphate Binding and Subunit Assembly

Crystal Structure of the Anthrax Drug Target, Bacillus anthracis Dihydrofolate Reductase

Pro-1 of Macrophage Migration Inhibitory Factor Functions as a Catalytic Base in the Phenylpyruvate Tautomerase Activity

Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy

Crystal Structure of Chemically Synthesized [N33A] Stromal Cell-Derived Factor 1α , a Potent Ligand for the HIV-1 ``Fusin" Coreceptor

Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease

X-ray structure of the ternary MTX·NADPH complex of the anthrax dihydrofolate reductase: A pharmacophore for dual-site inhibitor design

Towards understanding the structure-function relationship of human amyloid disease

Protein structures by spallation neutron crystallography

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