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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2794-2809

2016

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Synthesis of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, and 2-Pyrazolylbenzohydrazide via 3-Substituted 3-Hydroxyisoindolin-1-ones

Journal of organic chemistry, 2012-04, Vol.77 (8), p.3887-3906

2012

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Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors

Journal of medicinal chemistry, 2011-12, Vol.54 (24), p.8440-8450

2011

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Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines

Cancer research (Chicago, Ill.), 2010-12, Vol.70 (23), p.9846-9854

2010

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Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor

Journal of medicinal chemistry, 2010-09, Vol.53 (17), p.6368-6377

2010

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Abstract 5776: Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of aurora kinases with efficacy in preclinical antitumor models and activity against multidrug-resistant cells

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.5776-5776

2010

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Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.424-427

2009

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N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1172-1176

2008

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Intramolecular Cyclobutadiene Cycloaddition/Cyclopropanation/Thermal Rearrangement: An Effective Strategy for the Asymmetric Syntheses of Pleocarpenene and Pleocarpenone

Journal of the American Chemical Society, 2007-01, Vol.129 (3), p.486-487

2007

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Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity

Journal of medicinal chemistry, 2006-09, Vol.49 (19), p.5671-5686

2006

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Lewis Acid-Mediated Generation of Bicyclo[5.3.0]decanes and Bicyclo[4.3.0]nonanes

Organic letters, 2005-12, Vol.7 (26), p.5785-5788

2005

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ChemInform Abstract: New Approach to Bicyclo [5.3.0] Ring Systems

ChemInform, 2001-09, Vol.32 (38), p.no-no

2001

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New Approach to Bicyclo [5.3.0] Ring Systems

Journal of the American Chemical Society, 2001-05, Vol.123 (21), p.5152-5153

2001

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ChemInform Abstract: PREPARATION AND INVESTIGATION OF LEWIS ACID COMPLEXES PART 9, REACTIONS OF PENTA‐O‐ACETYL‐BETA‐D‐GLUCOPYRANOSE AND PENTA‐O‐ACETYL‐BETA‐D‐GALACTOPYRANOSE WITH TITANIUM TETRACHLORIDE

Chemischer Informationsdienst, 1974-06, Vol.5 (22)

1974

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Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity

Discovery of N‑(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine (AMG 900), A Highly Selective, Orally Bioavailable Inhibitor of Aurora Kinases with Activity against Multidrug-Resistant Cancer Cell Lines

Synthesis of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, and 2-Pyrazolylbenzohydrazide via 3-Substituted 3-Hydroxyisoindolin-1-ones

Discovery of Potent and Highly Selective Thienopyridine Janus Kinase 2 Inhibitors

Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines

Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor

Abstract 5776: Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of aurora kinases with efficacy in preclinical antitumor models and activity against multidrug-resistant cells

Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure–Activity Relationships, and Inhibition of in Vivo T Cell Activation

N-(3-(Phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: Structure, synthesis and SAR

Intramolecular Cyclobutadiene Cycloaddition/Cyclopropanation/Thermal Rearrangement: An Effective Strategy for the Asymmetric Syntheses of Pleocarpenene and Pleocarpenone

Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity

Lewis Acid-Mediated Generation of Bicyclo[5.3.0]decanes and Bicyclo[4.3.0]nonanes

ChemInform Abstract: New Approach to Bicyclo [5.3.0] Ring Systems

New Approach to Bicyclo [5.3.0] Ring Systems

ChemInform Abstract: PREPARATION AND INVESTIGATION OF LEWIS ACID COMPLEXES PART 9, REACTIONS OF PENTA‐O‐ACETYL‐BETA‐D‐GLUCOPYRANOSE AND PENTA‐O‐ACETYL‐BETA‐D‐GALACTOPYRANOSE WITH TITANIUM TETRACHLORIDE

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