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MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition

The Journal of pharmacology and experimental therapeutics, 2015-12, Vol.355 (3), p.397-409

2015

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Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2983-2992

2017

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16801-16817

2022

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A Novel Method for the Preparation of 4‑Arylimidazolones

Organic letters, 2013-06, Vol.15 (11), p.2830-2833

2013

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Asymmetric Synthesis of (2S,3R)-Capreomycidine and the Total Synthesis of Capreomycin IB

Journal of the American Chemical Society, 2003-07, Vol.125 (28), p.8561-8565

2003

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Structure–Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.685-690

2018

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Synthesis, Structure−Activity Relationship and in Vivo Antiinflammatory Efficacy of Substituted Dipiperidines as CCR2 Antagonists

Journal of medicinal chemistry, 2007-11, Vol.50 (23), p.5561-5563

2007

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The asymmetric synthesis of (2 S ,3 R )-capreomycidine

Tetrahedron letters, 2001-05, Vol.42 (21), p.3529-3532

2001

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A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins

Science (American Association for the Advancement of Science), 2022-06, Vol.376 (6599), p.1321-1327

2022

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease

Journal of medicinal chemistry, 2022-12, Vol.65 (24), p.16801-16817

2022

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An efficient asymmetric synthesis of (2 S,3 S)- and (2 R,3 R)-β-hydroxyornithine

Tetrahedron letters, 2001-01, Vol.42 (2), p.183-185

2001

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Asymmetric Synthesis of (+)-Hypusine

Organic letters, 2001-12, Vol.3 (26), p.4287-4289

2001

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Abstract PR017: Discovery and clinical evaluation of a potent and selective A2A/2B dual receptor antagonist

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.PR017-PR017

2023

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The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2601-2610

2014

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A Novel Carbohydrate-Glycosphingolipid Interaction between a β-(1–3)-Glucan Immunomodulator, PGG-glucan, and Lactosylceramide of Human Leukocytes

The Journal of biological chemistry, 1998-08, Vol.273 (34), p.22014-22020

1998

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Synthesis and structure–activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6468-6470

2008

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ChemInform Abstract: A Novel Method for the Preparation of 4-Arylimidazolones

ChemInform, 2013-10, Vol.44 (40), p.no-no

2013

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Substituted dipiperidine alcohols as potent CCR2 antagonists

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (12), p.3562-3564

2008

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Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists

Bioorganic & medicinal chemistry letters, 2007-11, Vol.17 (21), p.5964-5968

2007

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The first asymmetric synthesis of (2 S)- and (2 R)-amino-3,3-dimethoxypropanoic acid

Tetrahedron letters, 2002-03, Vol.43 (13), p.2355-2357

2002

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The asymmetric synthesis of (2S,3R)-capreomycidine and the total synthesis of capreomycin IB

DeMong, Duane Eugene

2003

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Asymmetric Synthesis of (2S,3R)-Capreomycidine and the Total Synthesis of Capreomycin IB

ChemInform, 2003-11, Vol.34 (45), p.no-no

2003

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Glucagon Receptor Antagonists for Type II Diabetes

Annual Reports in Medicinal Chemistry, 2008, Vol.43, p.119-137

2008

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ChemInform Abstract: The First Asymmetric Synthesis of (2S)- and (2R)-Amino-3,3-dimethoxypropanoic Acid

ChemInform, 2002-07, Vol.33 (29), p.no-no

2002

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ChemInform Abstract: The Asymmetric Synthesis of (2S,3R)-Capreomycidine

ChemInform, 2001-08, Vol.32 (32), p.no-no

2001

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MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition

Discovery of a 3‑(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease

A Novel Method for the Preparation of 4‑Arylimidazolones

Asymmetric Synthesis of (2S,3R)-Capreomycidine and the Total Synthesis of Capreomycin IB

Structure–Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs

Synthesis, Structure−Activity Relationship and in Vivo Antiinflammatory Efficacy of Substituted Dipiperidines as CCR2 Antagonists

The asymmetric synthesis of (2 S ,3 R )-capreomycidine

A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1‑Heteroaryl‑1H‑Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease

An efficient asymmetric synthesis of (2 S,3 S)- and (2 R,3 R)-β-hydroxyornithine

Asymmetric Synthesis of (+)-Hypusine

Abstract PR017: Discovery and clinical evaluation of a potent and selective A2A/2B dual receptor antagonist

The Discovery of N‑((2H‑Tetrazol-5-yl)methyl)-4-((R)‑1-((5r,8R)‑8‑(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

A Novel Carbohydrate-Glycosphingolipid Interaction between a β-(1–3)-Glucan Immunomodulator, PGG-glucan, and Lactosylceramide of Human Leukocytes

Synthesis and structure–activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists

ChemInform Abstract: A Novel Method for the Preparation of 4-Arylimidazolones

Substituted dipiperidine alcohols as potent CCR2 antagonists

Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists

The first asymmetric synthesis of (2 S)- and (2 R)-amino-3,3-dimethoxypropanoic acid

The asymmetric synthesis of (2S,3R)-capreomycidine and the total synthesis of capreomycin IB

Asymmetric Synthesis of (2S,3R)-Capreomycidine and the Total Synthesis of Capreomycin IB

Glucagon Receptor Antagonists for Type II Diabetes

ChemInform Abstract: The First Asymmetric Synthesis of (2S)- and (2R)-Amino-3,3-dimethoxypropanoic Acid

ChemInform Abstract: The Asymmetric Synthesis of (2S,3R)-Capreomycidine

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