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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

Science (American Association for the Advancement of Science), 2013-05, Vol.340 (6132), p.622-626

2013

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Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

Nature structural & molecular biology, 2003-10, Vol.10 (10), p.856-863

2003

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Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1

The Journal of biological chemistry, 2014-05, Vol.289 (20), p.13717-13725

2014

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Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition

PloS one, 2014-12, Vol.9 (12), p.e115144-e115144

2014

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Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

Nature structural & molecular biology, 2002-12, Vol.9 (12), p.950-957

2002

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NSF and p97/VCP: similar at first, different at last

FEBS letters, 2003-11, Vol.555 (1), p.126-133

2003

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Considerations for the refinement of low-resolution crystal structures

Acta crystallographica. Section D, Biological crystallography., 2006-08, Vol.62 (8), p.923-932

2006

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An allosteric mechanism for potent inhibition of human ATP-citrate lyase

Nature (London), 2019-04, Vol.568 (7753), p.566-570

2019

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Crystal Structure of a Hyperactive Escherichia coli Glycerol Kinase Mutant Gly230 → Asp Obtained Using Microfluidic Crystallization Devices

Biochemistry (Easton), 2007-05, Vol.46 (19), p.5722-5731

2007

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X-ray structure determination at low resolution

Acta crystallographica. Section D, Biological crystallography., 2009-02, Vol.65 (2), p.128-133

2009

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Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.4430-4449

2021

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AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency

Blood, 2017-09, Vol.130 (11), p.1347-1356

2017

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Dimerization of Recombinant Tobacco Mosaic Virus Movement Protein

Journal of Virology, 2004-04, Vol.78 (7), p.3372-3377

2004

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Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor

Biochemistry (Easton), 2011-12, Vol.50 (50), p.10764-10770

2011

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Central Pore Residues Mediate the p97/VCP Activity Required for ERAD

Molecular cell, 2006-05, Vol.22 (4), p.451-462

2006

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Nucleotide Dependent Motion and Mechanism of Action of p97/VCP

Journal of molecular biology, 2005-03, Vol.347 (2), p.437-452

2005

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Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases

Nature structural & molecular biology, 2000-03, Vol.7 (3), p.238-244

2000

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Cryo-EM structure of human ATP-citrate lyase in complex with a potent inhibitor

Acta crystallographica. Section A, Foundations and advances, 2019-07, Vol.75 (a1), p.a371-a371

2019

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Abstract 3237: XRay structure of human glutaminase in complex with BPTES and analysis of BPTES-resistant mutants

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.3237-3237

2012

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Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

Chemistry & biology, 2012-09, Vol.19 (9), p.1187-1198

2012

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Abstract ND08: Discovery of FX-909, a first-in-class inverse agonist of the peroxisome proliferator-activated receptor gamma (PPARG) lineage transcription factor, to potentially treat patients with the luminal subtype of advanced urothelial cancer (UC)

Cancer research (Chicago, Ill.), 2023-05, Vol.83 (7_Supplement), p.ND08-ND08

2023

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Structural Biology of Mutant IDH2 Inhibition

Acta crystallographica. Section A, Foundations and advances, 2014-08, Vol.70 (a1), p.C799-C799

2014

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Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Blood, 2013-11, Vol.122 (21), p.2180-2180

2013

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Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition

Cancer & metabolism, 2014-05, Vol.2 (S1), p.P78-P78, Article P78

2014

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Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition

Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

NSF and p97/VCP: similar at first, different at last

Considerations for the refinement of low-resolution crystal structures

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

Crystal Structure of a Hyperactive Escherichia coli Glycerol Kinase Mutant Gly230 → Asp Obtained Using Microfluidic Crystallization Devices

X-ray structure determination at low resolution

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion

AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency

Dimerization of Recombinant Tobacco Mosaic Virus Movement Protein

Full-Length Human Glutaminase in Complex with an Allosteric Inhibitor

Central Pore Residues Mediate the p97/VCP Activity Required for ERAD

Nucleotide Dependent Motion and Mechanism of Action of p97/VCP

Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases

Cryo-EM structure of human ATP-citrate lyase in complex with a potent inhibitor

Abstract 3237: XRay structure of human glutaminase in complex with BPTES and analysis of BPTES-resistant mutants

Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy

Abstract ND08: Discovery of FX-909, a first-in-class inverse agonist of the peroxisome proliferator-activated receptor gamma (PPARG) lineage transcription factor, to potentially treat patients with the luminal subtype of advanced urothelial cancer (UC)

Structural Biology of Mutant IDH2 Inhibition

Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia

Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition

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