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A defined structural unit enables de novo design of small-molecule-binding proteins

Science (American Association for the Advancement of Science), 2020-09, Vol.369 (6508), p.1227-1233

2020

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Signal Transduction in Histidine Kinases: Insights from New Structures

Structure (London), 2015-06, Vol.23 (6), p.981-994

2015

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The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives

Chemistry : a European journal, 2009-01, Vol.15 (5), p.1123-1133

2009

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Structural basis for proton conduction and inhibition by the influenza M2 protein

Protein science, 2012-11, Vol.21 (11), p.1620-1633

2012

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Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

Nature communications, 2017-11, Vol.8 (1), p.1365-10, Article 1365

2017

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Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16

Antimicrobial agents and chemotherapy, 2014-09, Vol.58 (9), p.5136-5145

2014

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Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters

Journal of the American Chemical Society, 2018-11, Vol.140 (45), p.15219-15226

2018

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Salt bridges: Geometrically specific, designable interactions

Proteins, structure, function, and bioinformatics, 2011-03, Vol.79 (3), p.898-915

2011

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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

Nature (London), 2010-02, Vol.463 (7281), p.689-692

2010

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De novo design of a transmembrane Zn2+-transporting four-helix bundle

Science (American Association for the Advancement of Science), 2014-12, Vol.346 (6216), p.1520-1524

2014

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De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

Accounts of chemical research, 2010-01, Vol.43 (1), p.30-39

2010

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Packing of apolar side chains enables accurate design of highly stable membrane proteins

Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6434), p.1418-1423

2019

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Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics

Journal of the American Chemical Society, 2020-10, Vol.142 (41), p.17425-17433

2020

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Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments

Nature communications, 2023-05, Vol.14 (1), p.3048-11, Article 3048

2023

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Amphiphilic Polymethacrylate Derivatives as Antimicrobial Agents

Journal of the American Chemical Society, 2005-03, Vol.127 (12), p.4128-4129

2005

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Cys-Scanning Disulfide Crosslinking and Bayesian Modeling Probe the Transmembrane Signaling Mechanism of the Histidine Kinase, PhoQ

Structure (London), 2014-09, Vol.22 (9), p.1239-1251

2014

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Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins

Journal of the American Chemical Society, 2019-05, Vol.141 (19), p.7698-7703

2019

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Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.1315-1320

2013

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Allosteric cooperation in a de novo-designed two-domain protein

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (52), p.33246-33253

2020

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Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry

Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (44), p.11162-11167

2018

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Crystal structure of the drug‐resistant S31N influenza M2 proton channel

Protein science, 2016-08, Vol.25 (8), p.1551-1554

2016

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Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice

Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (28), p.10329-10334

2014

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Designed metalloprotein stabilizes a semiquinone radical

Nature chemistry, 2016-02, Vol.8 (4), p.354-359

2016

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The Membrane- and Soluble-Protein Helix-Helix Interactome: Similar Geometry via Different Interactions

Structure (London), 2015-03, Vol.23 (3), p.527-541

2015

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Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions

Nature communications, 2017-12, Vol.8 (1), p.2240-2240, Article 2240

2017

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A defined structural unit enables de novo design of small-molecule-binding proteins

Signal Transduction in Histidine Kinases: Insights from New Structures

The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of Polymethacrylate Derivatives

Structural basis for proton conduction and inhibition by the influenza M2 protein

Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

Comparative mechanistic studies of brilacidin, daptomycin, and the antimicrobial peptide LL16

Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters

Salt bridges: Geometrically specific, designable interactions

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

De novo design of a transmembrane Zn2+-transporting four-helix bundle

De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

Packing of apolar side chains enables accurate design of highly stable membrane proteins

Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics

Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments

Amphiphilic Polymethacrylate Derivatives as Antimicrobial Agents

Cys-Scanning Disulfide Crosslinking and Bayesian Modeling Probe the Transmembrane Signaling Mechanism of the Histidine Kinase, PhoQ

Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

Allosteric cooperation in a de novo-designed two-domain protein

Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry

Crystal structure of the drug‐resistant S31N influenza M2 proton channel

Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice

Designed metalloprotein stabilizes a semiquinone radical

The Membrane- and Soluble-Protein Helix-Helix Interactome: Similar Geometry via Different Interactions

Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions

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