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Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

Diabetologia, 2010-07, Vol.53 (7), p.1270-1287

DeFronzo, R. A.

2010

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The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia

Diabetes, obesity & metabolism, 2012-01, Vol.14 (1), p.5-14

2012

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Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp

Diabetes care, 1999-09, Vol.22 (9), p.1462-1470

1999

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Pharmacologic therapy for type 2 diabetes mellitus

Annals of internal medicine, 1999-08, Vol.131 (4), p.281

DeFronzo, R A

1999

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Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): a randomized trial

Diabetes, obesity & metabolism, 2015-03, Vol.17 (3), p.268-275

2015

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Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials

Diabetic medicine, 2010-03, Vol.27 (3), p.309-317

2010

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Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

Diabetologia, 2004, Vol.47 (1), p.31-39

2004

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Lowering plasma glucose concentration by inhibiting renal sodium–glucose cotransport

Journal of internal medicine, 2014-10, Vol.276 (4), p.352-363

2014

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Efficacy and Tolerability of the DPP-4 Inhibitor Alogliptin Combined with Pioglitazone, in Metformin-Treated Patients with Type 2 Diabetes

The journal of clinical endocrinology and metabolism, 2012-05, Vol.97 (5), p.1615-1622

2012

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Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

Diabetologia, 2011-12, Vol.54 (12), p.3132-3142

2011

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Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients

Diabetes, obesity & metabolism, 2008-12, Vol.10 (12), p.1204-1211

2008

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Dysfunctional fat cells, lipotoxicity and type 2 diabetes

International journal of clinical practice (Esher), 2004-10, Vol.58 (s143), p.9-21

Defronzo, R. A.

2004

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Effect of Exenatide on Splanchnic and Peripheral Glucose Metabolism in Type 2 Diabetic Subjects

The journal of clinical endocrinology and metabolism, 2011-06, Vol.96 (6), p.1763-1770

2011

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Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients

International Journal of Obesity, 2004-06, Vol.28 (6), p.783-789

2004

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Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial

Diabetologia, 2009-04, Vol.52 (4), p.723-732

2009

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Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus

Diabetologia, 2007-08, Vol.50 (8), p.1723-1731

2007

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Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes

Diabetologia, 2004-05, Vol.47 (5), p.816-820

2004

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Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients

Diabetologia, 2001-12, Vol.44 (12), p.2210-2219

2001

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Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study

Diabetologia, 2010-03, Vol.53 (3), p.435-445

2010

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Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels

Diabetologia, 2012-03, Vol.55 (3), p.719-728

2012

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Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

Diabetologia, 2009-10, Vol.52 (10), p.2169-2181

2009

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Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants

Diabetologia, 2009-04, Vol.52 (4), p.574-582

2009

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Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates

International Journal of Obesity, 2013-08, Vol.37 (8), p.1071-1078

2013

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Strong association between insulin resistance in liver and skeletal muscle in non-diabetic subjects

Diabetic medicine, 2008-11, Vol.25 (11), p.1289-1294

2008

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Pathogenesis of Type 2 (non-insulin dependent) diabetes mellitus : a balanced overview

Diabetologia, 1992-04, Vol.35 (4), p.389-397

DEFRONZO, R. A

1992

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Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009

The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia

Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp

Pharmacologic therapy for type 2 diabetes mellitus

Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): a randomized trial

Relationship of baseline HbA1c and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials

Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

Lowering plasma glucose concentration by inhibiting renal sodium–glucose cotransport

Efficacy and Tolerability of the DPP-4 Inhibitor Alogliptin Combined with Pioglitazone, in Metformin-Treated Patients with Type 2 Diabetes

Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism

Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients

Dysfunctional fat cells, lipotoxicity and type 2 diabetes

Effect of Exenatide on Splanchnic and Peripheral Glucose Metabolism in Type 2 Diabetic Subjects

Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients

Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial

Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus

Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes

Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients

Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study

Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels

Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans

Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants

Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates

Strong association between insulin resistance in liver and skeletal muscle in non-diabetic subjects

Pathogenesis of Type 2 (non-insulin dependent) diabetes mellitus : a balanced overview

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