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Underexplored Opportunities for Natural Products in Drug Discovery

Journal of medicinal chemistry, 2016-10, Vol.59 (20), p.9295-9304

DeCorte, Bart L

2016

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Evolving Outsourcing Landscape in Pharma R&D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11362-11367

DeCorte, Bart L

2020

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Evolving Outsourcing Landscape in Pharma R&D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization: Miniperspective

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.11362-11367

DeCorte, Bart L

2020

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Underexplored Opportunities for Natural Products in Drug Discovery: Miniperspective

Journal of medicinal chemistry, 2016-10, Vol.59 (20), p.9295-9304

DeCorte, Bart L

2016

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Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats

The Journal of pharmacology and experimental therapeutics, 2008-03, Vol.324 (3), p.894-901

2008

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Diabetogenic Effect of a Series of Tricyclic Delta Opioid Agonists Structurally Related to Cyproheptadine

Toxicological sciences, 2010-10, Vol.117 (2), p.493-504

2010

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Improved Strategies for Postoligomerization Synthesis of Oligodeoxynucleotides Bearing Structurally Defined Adducts at the N 2 Position of Deoxyguanosine

Chemical research in toxicology, 1996-04, Vol.9 (3), p.630-637

1996

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1,2,3,4-Tetrahydroquinoline-containing αvβ3 integrin antagonists with enhanced oral bioavailability

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (23), p.5937-5941

2004

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Synthesis of Oligonucleotides Containing Interchain Cross-Links of Bifunctional Pyrroles

Journal of the American Chemical Society, 1995-11, Vol.117 (44), p.11013-11014

1995

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Styrene Oxide Adducts in an Oligodeoxynucleotide Containing the Human N-ras Codon 12: Minor Groove Structures of the R(12,1)- and S(12,1)-α-(N2-Guanyl) Stereoisomers Determined by 1H Nuclear Magnetic Resonance

Chemical research in toxicology, 1998-07, Vol.11 (7), p.766-777

1998

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Combining Label‐free and Flourometric Functional Assays with Biophysical Binding Assays in Drug Discovery: A Comparison of Positives from an HTS Campaign

The FASEB journal, 2009-04, Vol.23 (S1)

2009

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Novel triazole based inhibitors of Ras farnesyl transferase

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5407-5411

2005

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Styrene Oxide Adducts in an Oligodeoxynucleotide Containing the Human N-ras Codon 12 Sequence: Structural Refinement of the Minor Groove R(12,2)- and S(12,2)-α-(N 2-Guanyl) Stereoisomers from 1H NMR

Biochemistry (Easton), 1996-04, Vol.35 (14), p.4334-4348

1996

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1,2,3,4-Tetrahydroquinoline-containing α Vβ 3 integrin antagonists with enhanced oral bioavailability

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (23), p.5937-5941

2004

Volltextzugriff (PDF)

1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability

Bioorganic & medicinal chemistry letters, 2004-12, Vol.14 (23), p.5937-5941

2004

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Styrene Oxide Adducts in an Oligodeoxynucleotide Containing the Human N-ras Codon 12: Minor Groove Structures of the R (12,1)- and S (12,1)-α-(N 2 -Guanyl) Stereoisomers Determined by 1 H Nuclear Magnetic Resonance

Chemical research in toxicology, 1998-07, Vol.11 (7), p.766-777

1998

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Styrene Oxide Adducts in an Oligodeoxynucleotide Containing the Human N-ras Codon 12 Sequence: Structural Refinement of the Minor Groove R(12,2)- and S(12,2)-α-( N 2 -Guanyl) Stereoisomers from 1 H NMR

Biochemistry (Easton), 1996-01, Vol.35 (14), p.4334-4348

1996

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Improved Strategies for Postoligomerization Synthesis of Oligodeoxynucleotides Bearing Structurally Defined Adducts at the N2 Position of Deoxyguanosine

Chemical research in toxicology, 1996-04, Vol.9 (3), p.630-637

1996

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Novel Triazole Based Inhibitors of Ras Farnesyl Transferase

ChemInform, 2006-03, Vol.37 (11), p.no-no

2006

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Fluoroolefin peptide isosteres - tools for controlling peptide conformations

Tetrahedron letters, 1994-08, Vol.35 (33), p.6033-6036

1994

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Comparison of the Efficiency of Synthesis Past Single Bulky DNA Adducts in Vivo and in Vitro by the Polymerase III Holoenzyme

Chemical research in toxicology, 1996-10, Vol.9 (7), p.1167-1175

1996

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Synthesis, fragmentations and rearrangements of 3-(1-haloalkyl)oxaziridines

Tetrahedron, 1992, Vol.48 (35), p.7345-7362

1992

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A convenient synthesis of C-unsubstituted and C-monoalkylated ketene imines by dehydrocyanation of imidoyl cyanides using vacuum gas-solid reactions

Journal of organic chemistry, 1987-03, Vol.52 (6), p.1147-1149

1987

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A Convenient Synthesis of 2,2-Dichloro-1-phenyl-1-alkanones and the Corresponding Imines

Synthesis (Stuttgart), 1990, Vol.1990 (8), p.675-677

1990

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Regioselective aza-Cope rearrangement of .alpha.-halogenated and nonhalogenated imines

Journal of organic chemistry, 1990-08, Vol.55 (17), p.4981-4983

1990

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Underexplored Opportunities for Natural Products in Drug Discovery

Evolving Outsourcing Landscape in Pharma R&D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization

Evolving Outsourcing Landscape in Pharma R&D: Different Collaborative Models and Factors To Consider When Choosing a Contract Research Organization: Miniperspective

Underexplored Opportunities for Natural Products in Drug Discovery: Miniperspective

Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats

Diabetogenic Effect of a Series of Tricyclic Delta Opioid Agonists Structurally Related to Cyproheptadine

Improved Strategies for Postoligomerization Synthesis of Oligodeoxynucleotides Bearing Structurally Defined Adducts at the N 2 Position of Deoxyguanosine

1,2,3,4-Tetrahydroquinoline-containing αvβ3 integrin antagonists with enhanced oral bioavailability

Synthesis of Oligonucleotides Containing Interchain Cross-Links of Bifunctional Pyrroles

Styrene Oxide Adducts in an Oligodeoxynucleotide Containing the Human N-ras Codon 12: Minor Groove Structures of the R(12,1)- and S(12,1)-α-(N2-Guanyl) Stereoisomers Determined by 1H Nuclear Magnetic Resonance

Combining Label‐free and Flourometric Functional Assays with Biophysical Binding Assays in Drug Discovery: A Comparison of Positives from an HTS Campaign

Novel triazole based inhibitors of Ras farnesyl transferase

Styrene Oxide Adducts in an Oligodeoxynucleotide Containing the Human N-ras Codon 12 Sequence: Structural Refinement of the Minor Groove R(12,2)- and S(12,2)-α-(N 2-Guanyl) Stereoisomers from 1H NMR

1,2,3,4-Tetrahydroquinoline-containing α Vβ 3 integrin antagonists with enhanced oral bioavailability

1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability

Styrene Oxide Adducts in an Oligodeoxynucleotide Containing the Human N-ras Codon 12: Minor Groove Structures of the R (12,1)- and S (12,1)-α-(N 2 -Guanyl) Stereoisomers Determined by 1 H Nuclear Magnetic Resonance

Styrene Oxide Adducts in an Oligodeoxynucleotide Containing the Human N-ras Codon 12 Sequence: Structural Refinement of the Minor Groove R(12,2)- and S(12,2)-α-( N 2 -Guanyl) Stereoisomers from 1 H NMR

Improved Strategies for Postoligomerization Synthesis of Oligodeoxynucleotides Bearing Structurally Defined Adducts at the N2 Position of Deoxyguanosine

Novel Triazole Based Inhibitors of Ras Farnesyl Transferase

Fluoroolefin peptide isosteres - tools for controlling peptide conformations

Comparison of the Efficiency of Synthesis Past Single Bulky DNA Adducts in Vivo and in Vitro by the Polymerase III Holoenzyme

Synthesis, fragmentations and rearrangements of 3-(1-haloalkyl)oxaziridines

A convenient synthesis of C-unsubstituted and C-monoalkylated ketene imines by dehydrocyanation of imidoyl cyanides using vacuum gas-solid reactions

A Convenient Synthesis of 2,2-Dichloro-1-phenyl-1-alkanones and the Corresponding Imines

Regioselective aza-Cope rearrangement of .alpha.-halogenated and nonhalogenated imines

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