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Promiscuous Targets for Antitubercular Drug Discovery: The Paradigm of DprE1 and MmpL3

Applied sciences, 2020-01, Vol.10 (2), p.623

2020

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Structural Plasticity and Distinct Drug-Binding Modes of LfrR, a Mycobacterial Efflux Pump Regulator

Journal of Bacteriology, 2009-12, Vol.191 (24), p.7531-7537

2009

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Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome

BMC microbiology, 2006-07, Vol.6 (1), p.66-66, Article 66

2006

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MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

Antimicrobial Agents and Chemotherapy, 2012-01, Vol.56 (1), p.324-331

2012

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Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

PloS one, 2013-02, Vol.8 (2), p.e56980

2013

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Functional and Genetic Characterization of the Tap Efflux Pump in Mycobacterium bovis BCG

Antimicrobial Agents and Chemotherapy, 2012-04, Vol.56 (4), p.2074-2083

2012

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Mechanism of Resistance to an Antitubercular 2-Thiopyridine Derivative That Is Also Active against Burkholderia cenocepacia

Antimicrobial agents and chemotherapy, 2014-04, Vol.58 (4), p.2415-2417

2014

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Role of mycobacterial efflux transporters in drug resistance: an unresolved question

FEMS microbiology reviews, 2006-01, Vol.30 (1), p.36-52

2006

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Molecular Characterization of the Burkholderia cenocepacia dcw Operon and FtsZ Interactors as New Targets for Novel Antimicrobial Design

Antibiotics (Basel), 2020-11, Vol.9 (12), p.841

2020

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Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

Frontiers in pharmacology, 2018-07, Vol.9, p.836-836

2018

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mmpL7 Gene of Mycobacterium tuberculosis Is Responsible for Isoniazid Efflux in Mycobacterium smegmatis

Antimicrobial Agents and Chemotherapy, 2005-11, Vol.49 (11), p.4775-4777

2005

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Bactericidal and Anti-Biofilm Activity of the FtsZ Inhibitor C109 against Acinetobacter baumannii

Antibiotics (Basel), 2022-11, Vol.11 (11), p.1571

2022

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Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy, 2004-08, Vol.48 (8), p.3175-3178

2004

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Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Molecular microbiology, 2010-09, Vol.77 (5), p.1172-1185

2010

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Eﬄux-mediated resistance to a benzothiadiazol derivative effective against Burkholderia cenocepacia

Frontiers in microbiology, 2015-08, Vol.6, p.815-815

2015

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Antistaphylococcal Activity of the FtsZ Inhibitor C109

Pathogens (Basel), 2021-07, Vol.10 (7), p.886

2021

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LfrR Is a Repressor That Regulates Expression of the Efflux Pump LfrA in Mycobacterium smegmatis

Antimicrobial Agents and Chemotherapy, 2006-12, Vol.50 (12), p.4044-4052

2006

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1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings

Journal of medicinal chemistry, 2008-06, Vol.51 (12), p.3644-3648

2008

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The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis

Molecular medicine (Cambridge, Mass.), 2002-11, Vol.8 (11), p.714-724

2002

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Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

Science (American Association for the Advancement of Science), 2009-05, Vol.324 (5928), p.801-804

2009

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mmr, a Mycobacterium tuberculosis Gene Conferring Resistance to Small Cationic Dyes and Inhibitors

Journal of Bacteriology, 1998-11, Vol.180 (22), p.6068-6071

1998

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Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis

Science translational medicine, 2012-09, Vol.4 (150), p.150ra121

2012

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Bactericidal and Anti-Biofilm Activity of the FtsZ Inhibitor C109 against IAcinetobacter baumannii/I

Antibiotics (Basel), 2022-11, Vol.11 (11)

2022

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Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD + synthetase

Protein expression and purification, 2002-08, Vol.25 (3), p.547-557

2002

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Promiscuous Targets for Antitubercular Drug Discovery: The Paradigm of DprE1 and MmpL3

Structural Plasticity and Distinct Drug-Binding Modes of LfrR, a Mycobacterial Efflux Pump Regulator

Efflux pump genes of the resistance-nodulation-division family in Burkholderia cenocepacia genome

MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212

Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

Functional and Genetic Characterization of the Tap Efflux Pump in Mycobacterium bovis BCG

Mechanism of Resistance to an Antitubercular 2-Thiopyridine Derivative That Is Also Active against Burkholderia cenocepacia

Role of mycobacterial efflux transporters in drug resistance: an unresolved question

Molecular Characterization of the Burkholderia cenocepacia dcw Operon and FtsZ Interactors as New Targets for Novel Antimicrobial Design

Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

mmpL7 Gene of Mycobacterium tuberculosis Is Responsible for Isoniazid Efflux in Mycobacterium smegmatis

Bactericidal and Anti-Biofilm Activity of the FtsZ Inhibitor C109 against Acinetobacter baumannii

Rv2686c-Rv2687c-Rv2688c, an ABC Fluoroquinolone Efflux Pump in Mycobacterium tuberculosis

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Eﬄux-mediated resistance to a benzothiadiazol derivative effective against Burkholderia cenocepacia

Antistaphylococcal Activity of the FtsZ Inhibitor C109

LfrR Is a Repressor That Regulates Expression of the Efflux Pump LfrA in Mycobacterium smegmatis

1,5-Diphenylpyrrole Derivatives as Antimycobacterial Agents. Probing the Influence on Antimycobacterial Activity of Lipophilic Substituents at the Phenyl Rings

The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

mmr, a Mycobacterium tuberculosis Gene Conferring Resistance to Small Cationic Dyes and Inhibitors

Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis

2‑Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1

Bactericidal and Anti-Biofilm Activity of the FtsZ Inhibitor C109 against IAcinetobacter baumannii/I

Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD + synthetase

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