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Design and synthesis of potential dual NK1/NK3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2014-01, Vol.24 (2), p.510-514

2014

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S35225 is a direct inhibitor of Plasminogen Activator Inhibitor type-1 activity in the blood

Thrombosis research, 2008-01, Vol.122 (2), p.265-270

2008

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Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury

FEBS letters, 1997-01, Vol.402 (2), p.111-115

1997

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ALLOSTERIC MODULATION OF MUSCARINIC M4 RECEPTORS IN THE TREATMENT OF SCHIZOPHRENIA: A PHARMACOLOGICAL COMPARISON OF LY2033298 VS VU0152099

Schizophrenia research, 2010-04, Vol.117 (2), p.264-264

2010

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Targeting ACE and ECE with dual acting inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1058-1062

2008

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Effects of Ceramide on Apoptosis, Proteoglycan Degradation, and Matrix Metalloproteinase Expression in Rabbit Articular Cartilage

Biochemical and biophysical research communications, 2000-01, Vol.267 (1), p.438-444

2000

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Urinary collagen type II C-telopeptide fragments are sensitive markers of matrix metalloproteinase-dependent cartilage degradation in rat adjuvant-induced arthritis

Journal of rheumatology, 2003-07, Vol.30 (7), p.1561

2003

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Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors

Bioorganic & medicinal chemistry, 2013-11, Vol.21 (22), p.7216-7221

2013

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Low Molecular Weight Activated Protein C Inhibitors as a Potential Treatment for Hemophilic Disorders

Journal of medicinal chemistry, 2006-08, Vol.49 (17), p.5047-5050

2006

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Chemoselective and stereoselective synthesis of gem-difluoro-β-aminoesters or gem-difluoro-β-lactams from ethylbromodifluoroacetate and imines during Reformatsky reaction

Tetrahedron, 2007-12, Vol.63 (50), p.12352-12366

2007

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Effects of Ceramide on Aggrecanase Activity in Rabbit Articular Cartilage

Biochemical and biophysical research communications, 2001-05, Vol.283 (5), p.1105-1110

2001

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New Prolyl Endopeptidase Inhibitors: In Vitro and in Vivo Activities of Azabicyclo[2.2.2]octane, Azabicyclo[2.2.1]heptane, and Perhydroindole Derivatives

Journal of medicinal chemistry, 1996-06, Vol.39 (12), p.2379-2391

1996

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Synthesis of α,α-Difluoro-β-amino Esters or gem-Difluoro-β-lactams as Potential Metallocarboxypeptidase Inhibitors

European Journal of Organic Chemistry, 2008-09, Vol.2008 (25), p.4277-4295

2008

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A convenient route to functionalized 3-amino- N-methylfuro[3,2- b]pyridine-2-carboxamides

Tetrahedron, 2011-07, Vol.67 (26), p.4767-4773

2011

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Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists

ACS medicinal chemistry letters, 2014-05, Vol.5 (5), p.550-555

2014

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Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.841-844

2009

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A convenient route to functionalized 3-amino-6-bromofuro[3,2- b]pyridine-2-carboxamides

Tetrahedron, 2010-06, Vol.66 (25), p.4490-4494

2010

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Influence of positive allosteric modulators on GABAB receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes

Journal of neurochemistry, 2008-04, Vol.105 (2), p.308-323

2008

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Design, Synthesis, and Optimization of Balanced Dual NK 1 /NK 3 Receptor Antagonists

ACS medicinal chemistry letters, 2014-05, Vol.5 (5), p.550-555

2014

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Influence of positive allosteric modulators on GABA(B) receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes

Journal of neurochemistry, 2008-04, Vol.105 (2), p.308

2008

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Selective blockade of neurokinin (NK)1 receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats

Journal of neurochemistry, 2001-03, Vol.76 (6), p.1949-1954

2001

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Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.2782-2782

2012

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Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors

Life sciences (1973), 2011-08, Vol.89 (7-8), p.259-268

2011

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Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: A comparison to other agents

European neuropsychopharmacology, 2008-10, Vol.18 (10), p.729-750

2008

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S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: A comparison to aprepitant (MK869) and paroxetine

European neuropsychopharmacology, 2010-09, Vol.20 (9), p.599-621

2010

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Design and synthesis of potential dual NK1/NK3 receptor antagonists

S35225 is a direct inhibitor of Plasminogen Activator Inhibitor type-1 activity in the blood

Activation of MMP-9 by neutrophil elastase in an in vivo model of acute lung injury

ALLOSTERIC MODULATION OF MUSCARINIC M4 RECEPTORS IN THE TREATMENT OF SCHIZOPHRENIA: A PHARMACOLOGICAL COMPARISON OF LY2033298 VS VU0152099

Targeting ACE and ECE with dual acting inhibitors

Effects of Ceramide on Apoptosis, Proteoglycan Degradation, and Matrix Metalloproteinase Expression in Rabbit Articular Cartilage

Urinary collagen type II C-telopeptide fragments are sensitive markers of matrix metalloproteinase-dependent cartilage degradation in rat adjuvant-induced arthritis

Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors

Low Molecular Weight Activated Protein C Inhibitors as a Potential Treatment for Hemophilic Disorders

Chemoselective and stereoselective synthesis of gem-difluoro-β-aminoesters or gem-difluoro-β-lactams from ethylbromodifluoroacetate and imines during Reformatsky reaction

Effects of Ceramide on Aggrecanase Activity in Rabbit Articular Cartilage

New Prolyl Endopeptidase Inhibitors: In Vitro and in Vivo Activities of Azabicyclo[2.2.2]octane, Azabicyclo[2.2.1]heptane, and Perhydroindole Derivatives

Synthesis of α,α-Difluoro-β-amino Esters or gem-Difluoro-β-lactams as Potential Metallocarboxypeptidase Inhibitors

A convenient route to functionalized 3-amino- N-methylfuro[3,2- b]pyridine-2-carboxamides

Design, Synthesis, and Optimization of Balanced Dual NK1/NK3 Receptor Antagonists

Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues

A convenient route to functionalized 3-amino-6-bromofuro[3,2- b]pyridine-2-carboxamides

Influence of positive allosteric modulators on GABAB receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes

Design, Synthesis, and Optimization of Balanced Dual NK 1 /NK 3 Receptor Antagonists

Influence of positive allosteric modulators on GABA(B) receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes

Selective blockade of neurokinin (NK)1 receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats

Abstract 2782: Bcl-2 selective antagonists show antitumor activity without dose limiting platelet toxicity

Characterization of novel Checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors

Cellular and behavioural profile of the novel, selective neurokinin1 receptor antagonist, vestipitant: A comparison to other agents

S41744, a dual neurokinin (NK)1 receptor antagonist and serotonin (5-HT) reuptake inhibitor with potential antidepressant properties: A comparison to aprepitant (MK869) and paroxetine

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