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Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

eLife, 2015-12, Vol.4

2015

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Structural basis for itraconazole-mediated NPC1 inhibition

Nature communications, 2020-01, Vol.11 (1), p.152-152, Article 152

2020

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Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

Nature (London), 2019-03, Vol.567 (7748), p.341-346

2019

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Lessons and revelations from biomimetic syntheses

Nature chemical biology, 2011-11, Vol.7 (12), p.865-875

2011

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Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK‐925 and ARN‐776 in narcoleptic orexin/tTA; TetO‐DTA mice

Journal of sleep research, 2023-08, Vol.32 (4), p.e13839-n/a

2023

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Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (1), p.89-94

2017

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Molecular mechanism of the wake-promoting agent TAK-925

Nature communications, 2022-05, Vol.13 (1), p.2902-12, Article 2902

2022

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Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

Science translational medicine, 2016-10, Vol.8 (361), p.361ra140

2016

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Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A

Journal of the American Chemical Society, 2007-05, Vol.129 (20), p.6386-6387

2007

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Reply to: The G protein preference of orexin receptors is currently an unresolved issue

Nature communications, 2023-06, Vol.14 (1), p.3163-3163, Article 3163

2023

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Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B

Journal of the American Chemical Society, 2016-06, Vol.138 (22), p.7130-7142

2016

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Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles

ACS nano, 2013-08, Vol.7 (8), p.6884-6893

2013

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Lessons and revelations from biomimetic syntheses

Nature chemical biology, 2011-12, Vol.7 (12), p.865

2011

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Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs

The Journal of biological chemistry, 2004-12, Vol.279 (50), p.52772-52780

2004

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A Concise Synthesis of Berkelic Acid Inspired by Combining the Natural Products Spicifernin and Pulvilloric Acid

Journal of the American Chemical Society, 2009-08, Vol.131 (32), p.11350-11352

2009

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Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters

Organic letters, 2008-06, Vol.10 (12), p.2533-2536

2008

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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

Cancer discovery, 2017-08, Vol.7 (8), p.832-851

2017

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Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals

Organic letters, 2006-10, Vol.8 (21), p.4907-4910

2006

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Structural insights for selective disruption of Beclin 1 binding to Bcl-2

Communications biology, 2023-10, Vol.6 (1), p.1080-1080, Article 1080

2023

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Isolation, Structure, and Total Synthesis of the Marine Macrolide Mangrolide D

Organic letters, 2019-04, Vol.21 (8), p.2957-2961

2019

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Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes

Autophagy, 2017-04, Vol.13 (4), p.670-685

2017

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Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines

PloS one, 2010-07, Vol.5 (7), p.e11629

2010

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A convergent approach toward fidaxomicin: Syntheses of the fully glycosylated northern and southern fragments

Tetrahedron, 2020-12, Vol.76 (49), p.131673, Article 131673

2020

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The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections

British journal of pharmacology, 2011-09, Vol.164 (2), p.344-357

2011

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Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

Structural basis for itraconazole-mediated NPC1 inhibition

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

Lessons and revelations from biomimetic syntheses

Evaluation of the efficacy of the hypocretin/orexin receptor agonists TAK‐925 and ARN‐776 in narcoleptic orexin/tTA; TetO‐DTA mice

Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer

Triazoles inhibit cholesterol export from lysosomes by binding to NPC1

Molecular mechanism of the wake-promoting agent TAK-925

Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer

Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A

Reply to: The G protein preference of orexin receptors is currently an unresolved issue

Rifamycin Biosynthetic Congeners: Isolation and Total Synthesis of Rifsaliniketal and Total Synthesis of Salinisporamycin and Saliniketals A and B

Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles

Lessons and revelations from biomimetic syntheses

Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs

A Concise Synthesis of Berkelic Acid Inspired by Combining the Natural Products Spicifernin and Pulvilloric Acid

Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters

Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

Metal-Catalyzed Regioselective Oxy-Functionalization of Internal Alkynes: An Entry into Ketones, Acetals, and Spiroketals

Structural insights for selective disruption of Beclin 1 binding to Bcl-2

Isolation, Structure, and Total Synthesis of the Marine Macrolide Mangrolide D

Disruption of the vacuolar-type H+-ATPase complex in liver causes MTORC1-independent accumulation of autophagic vacuoles and lysosomes

Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines

A convergent approach toward fidaxomicin: Syntheses of the fully glycosylated northern and southern fragments

The proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections

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