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Screening for AMPA receptor auxiliary subunit specific modulators

PloS one, 2017-03, Vol.12 (3), p.e0174742-e0174742

2017

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Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Molecular pharmacology, 2008-11, Vol.74 (5), p.1345-1358

2008

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Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B K ATP Channels

Molecular pharmacology, 2024-03, Vol.105 (3), p.202-212

2024

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Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

Molecular pharmacology, 2010-12, Vol.78 (6), p.1105-1123

2010

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Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS

Bioorganic & medicinal chemistry letters, 2023-05, Vol.87, p.129256-129256, Article 129256

2023

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VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

Molecular pharmacology, 2022-05, Vol.101 (5), p.357-370

2022

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Discovery of (S)‑2-Cyclopentyl‑N‑((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro‑1H‑pyrrido[3,4‑b]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.10192-10197

2014

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Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1611-1616

2017

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Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

ACS chemical neuroscience, 2014-12, Vol.5 (12), p.1221-1237

2014

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Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity

Molecular pharmacology, 2009-03, Vol.75 (3), p.577-588

2009

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A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors

Journal of biomolecular screening, 2014-07, Vol.19 (6), p.847-858

2014

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Discovery of N-Aryl Piperazines as Selective mGluR5 Potentiators with Improved In Vivo Utility

ACS medicinal chemistry letters, 2010-11, Vol.1 (8), p.433-438

2010

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Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly

Journal of neuroimmunology, 2005-09, Vol.166 (1), p.88-101

2005

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Discovery of ( S )-2-Cyclopentyl- N -((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1 H -pyrrido[3,4- b ]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.10192-10197

2014

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Discovery and Characterization of Novel Allosteric Potentiators of M 1 Muscarinic Receptors Reveals Multiple Modes of Activity

Molecular pharmacology, 2009-03, Vol.75 (3), p.577-588

2009

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Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic ActivityS

Molecular pharmacology, 2010-12, Vol.78 (6), p.1105-1123

2010

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Discovery of N -Aryl Piperazines as Selective mGluR 5 Potentiators with Improved In Vivo Utility

ACS medicinal chemistry letters, 2010-11, Vol.1 (8), p.433-438

2010

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Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity

ACS medicinal chemistry letters, 2010-11, Vol.1 (8), p.433-438

2010

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Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide‑1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5‑d]pyrimidine-2,4(1H,3H)‑dione Core

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1611-1616

2017

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Age‐related loss of neuronal nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase‐2 and PPARγ expression and is altered by long‐term NS398 administration

Journal of neurobiology, 2005-03, Vol.62 (4), p.453-468

2005

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Neurodegenerative disease and the neuroimmunobiology of glutamate receptors

Advances in Molecular and Cell Biology, 2004, Vol.32, p.141-159

2004

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Age-related loss of neuronal nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase-2 and PPAR? expression and is altered by long-term NS398 administration

Journal of neurobiology, 2005-03, Vol.62 (4), p.453-468

2005

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Proteogenomic Characterization of Endometrial Carcinoma

Cell, 2020-02, Vol.180 (4), p.729-748.e26

2020

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Quantification of siRNA Duplexes Bound to Gold Nanoparticle Surfaces

Methods in molecular biology (Clifton, N.J.), 2017, Vol.1570, p.1

2017

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Follow-up of Glycemic Control and Cardiovascular Outcomes in Type 2 Diabetes

The New England journal of medicine, 2015-06, Vol.372 (23), p.2197-2206

2015

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Screening for AMPA receptor auxiliary subunit specific modulators

Discovery, Characterization, and Antiparkinsonian Effect of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4

Discovery and Characterization of VU0542270, the First Selective Inhibitor of Vascular Kir6.1/SUR2B K ATP Channels

Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity

Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS

VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

Discovery of (S)‑2-Cyclopentyl‑N‑((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro‑1H‑pyrrido[3,4‑b]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)

Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity

A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 and Glucagon Receptors

Discovery of N-Aryl Piperazines as Selective mGluR5 Potentiators with Improved In Vivo Utility

Pro-inflammatory cytokines modify neuronal nicotinic acetylcholine receptor assembly

Discovery of ( S )-2-Cyclopentyl- N -((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1 H -pyrrido[3,4- b ]indole-4-carboxamide (VU0453379): A Novel, CNS Penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) Positive Allosteric Modulator (PAM)

Discovery and Characterization of Novel Allosteric Potentiators of M 1 Muscarinic Receptors Reveals Multiple Modes of Activity

Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic ActivityS

Discovery of N -Aryl Piperazines as Selective mGluR 5 Potentiators with Improved In Vivo Utility

Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity

Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide‑1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5‑d]pyrimidine-2,4(1H,3H)‑dione Core

Age‐related loss of neuronal nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase‐2 and PPARγ expression and is altered by long‐term NS398 administration

Neurodegenerative disease and the neuroimmunobiology of glutamate receptors

Age-related loss of neuronal nicotinic receptor expression in the aging mouse hippocampus corresponds with cyclooxygenase-2 and PPAR? expression and is altered by long-term NS398 administration

Proteogenomic Characterization of Endometrial Carcinoma

Quantification of siRNA Duplexes Bound to Gold Nanoparticle Surfaces

Follow-up of Glycemic Control and Cardiovascular Outcomes in Type 2 Diabetes

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