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Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

Biochemical journal, 2013-07, Vol.453 (2), p.219-230

2013

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Conformational Rearrangements in the Redox Cycling of NADPH-Cytochrome P450 Reductase from Sorghum bicolor Explored with FRET and Pressure-Perturbation Spectroscopy

Biology (Basel, Switzerland), 2022-03, Vol.11 (4), p.510

2022

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Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy

Biophysical journal, 2016-04, Vol.110 (7), p.1485-1498

2016

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Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

Expert opinion on drug metabolism & toxicology, 2008-12, Vol.4 (12), p.1523-1535

2008

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Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine by Cytochrome P450 3A4 Active Site Mutants Inspired by Molecular Dynamics Simulations

Biochemistry (Easton), 2015-01, Vol.54 (3), p.711-721

2015

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Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism

Trends in pharmacological sciences (Regular ed.), 2021-12, Vol.42 (12), p.988-997

2021

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A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET)

PloS one, 2013-12, Vol.8 (12), p.e83898

2013

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Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry

Biomolecules (Basel, Switzerland), 2022-01, Vol.12 (2), p.185

2022

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High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-Evaluate the Pathways of Ketamine Metabolism

Biology (Basel, Switzerland), 2023-07, Vol.12 (8), p.1055

2023

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A Pathfinder in High-Pressure Bioscience: In Memoriam of Gaston Hui Bon Hoa

Biology (Basel, Switzerland), 2021-08, Vol.10 (8), p.778

2021

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Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions

Expert opinion on drug metabolism & toxicology, 2011-05, Vol.7 (5), p.543-558

Davydov, Dmitri R

2011

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Structure and Function of the Cytochrome P450 Monooxygenase Cinnamate 4-hydroxylase from Sorghum bicolor

Plant physiology (Bethesda), 2020-07, Vol.183 (3), p.957-973

2020

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Resolution of Multiple Substrate Binding Sites in Cytochrome P450 3A4: The Stoichiometry of the Enzyme−Substrate Complexes Probed by FRET and Job's Titration

Biochemistry (Easton), 2006-04, Vol.45 (13), p.4199-4209

2006

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Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences

The Journal of biological chemistry, 2015-02, Vol.290 (6), p.3850-3864

2015

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Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics

Archives of biochemistry and biophysics, 2021-09, Vol.708, p.108937-108937, Article 108937

2021

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Functional and structural insight into the flexibility of cytochrome P450 reductases from Sorghum bicolor and its implications for lignin composition

The Journal of biological chemistry, 2022-04, Vol.298 (4), p.101761-101761, Article 101761

2022

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Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4

Archives of biochemistry and biophysics, 2021-02, Vol.698, p.108677-108677, Article 108677

2021

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Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2

Biochemical journal, 2019-12, Vol.476 (23), p.3661-3685

2019

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Pressure tolerance of deep‐sea enzymes can be evolved through increasing volume changes in protein transitions: a study with lactate dehydrogenases from abyssal and hadal fishes

The FEBS journal, 2020-12, Vol.287 (24), p.5394-5410

2020

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Mechanisms that regulate production of reactive oxygen species by cytochrome P450

Toxicology and Applied Pharmacology, 2004-09, Vol.199 (3), p.316-331

2004

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Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity

Drug metabolism and disposition, 2005-08, Vol.33 (8), p.1131

2005

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Quantitative proteomics identifies significant changes in the abundance and composition of hepatic drug metabolizing enzymes in heavy alcohol drinkers

Drug metabolism and pharmacokinetics, 2024-04, Vol.55, p.100926, Article 100926

2024

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Nonadditivity in human microsomal drug metabolism revealed in a study with coumarin 152, a polyspecific cytochrome P450 substrate

Xenobiotica, 2020-12, Vol.50 (12), p.1393-1405

2020

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Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation

Biochemical pharmacology, 2018-10, Vol.156, p.86-98

2018

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CYP261 enzymes from deep sea bacteria: A clue to conformational heterogeneity in cytochromes P450

Biotechnology and applied biochemistry, 2013-01, Vol.60 (1), p.30-40

2013

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Pivotal role of P450-P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

Conformational Rearrangements in the Redox Cycling of NADPH-Cytochrome P450 Reductase from Sorghum bicolor Explored with FRET and Pressure-Perturbation Spectroscopy

Conformational Mobility in Cytochrome P450 3A4 Explored by Pressure-Perturbation EPR Spectroscopy

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

Concurrent Cooperativity and Substrate Inhibition in the Epoxidation of Carbamazepine by Cytochrome P450 3A4 Active Site Mutants Inspired by Molecular Dynamics Simulations

Assembling the P450 puzzle: on the sources of nonadditivity in drug metabolism

A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET)

Exploring the Interactome of Cytochrome P450 2E1 in Human Liver Microsomes with Chemical Crosslinking Mass Spectrometry

High-Throughput Assay of Cytochrome P450-Dependent Drug Demethylation Reactions and Its Use to Re-Evaluate the Pathways of Ketamine Metabolism

A Pathfinder in High-Pressure Bioscience: In Memoriam of Gaston Hui Bon Hoa

Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions

Structure and Function of the Cytochrome P450 Monooxygenase Cinnamate 4-hydroxylase from Sorghum bicolor

Resolution of Multiple Substrate Binding Sites in Cytochrome P450 3A4: The Stoichiometry of the Enzyme−Substrate Complexes Probed by FRET and Job's Titration

Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences

Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics

Functional and structural insight into the flexibility of cytochrome P450 reductases from Sorghum bicolor and its implications for lignin composition

Effects of alcohol-induced increase in CYP2E1 content in human liver microsomes on the activity and cooperativity of CYP3A4

Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2

Pressure tolerance of deep‐sea enzymes can be evolved through increasing volume changes in protein transitions: a study with lactate dehydrogenases from abyssal and hadal fishes

Mechanisms that regulate production of reactive oxygen species by cytochrome P450

Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity

Quantitative proteomics identifies significant changes in the abundance and composition of hepatic drug metabolizing enzymes in heavy alcohol drinkers

Nonadditivity in human microsomal drug metabolism revealed in a study with coumarin 152, a polyspecific cytochrome P450 substrate

Kinetic mechanism of time-dependent inhibition of CYP2D6 by 3,4-methylenedioxymethamphetamine (MDMA): Functional heterogeneity of the enzyme and the reversibility of its inactivation

CYP261 enzymes from deep sea bacteria: A clue to conformational heterogeneity in cytochromes P450

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