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Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Cell, 2016-06, Vol.165 (7), p.1698-1707

2016

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Comprehensive analysis of kinase inhibitor selectivity

Nature biotechnology, 2011-11, Vol.29 (11), p.1046-1051

2011

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A quantitative analysis of kinase inhibitor selectivity

Nature biotechnology, 2008-01, Vol.26 (1), p.127-132

2008

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Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

The Journal of biological chemistry, 2016-11, Vol.291 (47), p.24628-24640

2016

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Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1

The Journal of biological chemistry, 2014-05, Vol.289 (20), p.13717-13725

2014

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Crystal Structure of Prostate-Specific Membrane Antigen, a Tumor Marker and Peptidase

Proceedings of the National Academy of Sciences - PNAS, 2005-04, Vol.102 (17), p.5981-5986

2005

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Diaphorase Coupling Protocols for Red-Shifting Dehydrogenase Assays

Assay and drug development technologies, 2016-04, Vol.14 (3), p.207

2016

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A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation

PloS one, 2013-01, Vol.8 (1), p.e54127-e54127

2013

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Identification of potent Yes1 kinase inhibitors using a library screening approach

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (15), p.4398-4403

2013

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Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes

Chemical reviews, 2000-01, Vol.100 (1), p.235-350

2000

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Spectroscopic and Electronic Structure Study of the Enzyme−Substrate Complex of Intradiol Dioxygenases: Substrate Activation by a High-Spin Ferric Non-heme Iron Site

Journal of the American Chemical Society, 2007-02, Vol.129 (7), p.1944-1958

2007

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A panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human disease

PloS one, 2014-02, Vol.9 (2), p.e89335-e89335

2014

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A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

Clinical cancer research, 2019-02, Vol.25 (4), p.1343-1357

2019

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A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion

Biochemical and biophysical research communications, 2024-07, Vol.718, p.149981-149981, Article 149981

2024

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Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells

Biochemical and biophysical research communications, 2023-10, Vol.679, p.116-121

2023

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Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development

The Journal of infectious diseases, 2023-10, Vol.228 (Supplement_5), p.S337-S354

2023

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Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma

Clinical cancer research, 2017-12, Vol.23 (23), p.7301-7311

2017

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High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

Clinical cancer research, 2019-07, Vol.25 (14), p.4552-4566

2019

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Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

Scientific reports, 2017-10, Vol.7 (1), p.12758-15, Article 12758

2017

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Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase, and PI5P4Kα Lipid Kinase

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1360, p.47

2016

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Avoiding Fluorescence Assay Interference-The Case for Diaphorase

Assay and drug development technologies, 2016-04, Vol.14 (3), p.175

2016

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Method for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent Format

Methods in molecular biology (Clifton, N.J.), 2016, Vol.1376, p.1

2016

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Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Comprehensive analysis of kinase inhibitor selectivity

A quantitative analysis of kinase inhibitor selectivity

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

Biochemical, Cellular, and Biophysical Characterization of a Potent Inhibitor of Mutant Isocitrate Dehydrogenase IDH1

Crystal Structure of Prostate-Specific Membrane Antigen, a Tumor Marker and Peptidase

Diaphorase Coupling Protocols for Red-Shifting Dehydrogenase Assays

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation

Identification of potent Yes1 kinase inhibitors using a library screening approach

Geometric and Electronic Structure/Function Correlations in Non-Heme Iron Enzymes

Spectroscopic and Electronic Structure Study of the Enzyme−Substrate Complex of Intradiol Dioxygenases: Substrate Activation by a High-Spin Ferric Non-heme Iron Site

A panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human disease

Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling

A Combination CDK4/6 and IGF1R Inhibitor Strategy for Ewing Sarcoma

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells

Discovery and Optimization of 2H‑1λ2‑Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer

Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development

Matrix Screen Identifies Synergistic Combination of PARP Inhibitors and Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors in Ewing Sarcoma

High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

Bioluminescence Methods for Assaying Kinases in Quantitative High-Throughput Screening (qHTS) Format Applied to Yes1 Tyrosine Kinase, Glucokinase, and PI5P4Kα Lipid Kinase

Avoiding Fluorescence Assay Interference-The Case for Diaphorase

Method for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent Format

Discovery and Optimization of 2 H -1λ 2 -Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer

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