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Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C

International journal of molecular sciences, 2023-08, Vol.24 (15), p.12349

2023

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Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure–Activity Relationship

Journal of chemical information and modeling, 2023-06, Vol.63 (11), p.3462-3473

2023

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NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling

The Journal of clinical investigation, 2023-04, Vol.133 (7), p.1-14

2023

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Binding of calcium and magnesium to human cardiac troponin C

The Journal of biological chemistry, 2021-01, Vol.296, p.100350-100350, Article 100350

2021

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Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure

Science translational medicine, 2017-07, Vol.9 (400)

2017

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Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy

Frontiers in physiology, 2017-08, Vol.8, p.614-614

2017

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NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Nature communications, 2018-08, Vol.9 (1), p.3431-14, Article 3431

2018

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Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers

Scientific reports, 2022-10, Vol.12 (1), p.18116-18116, Article 18116

2022

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The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

Cell calcium (Edinburgh), 2019-09, Vol.82 (9), p.102063-102063, Article 102063

2019

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Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

International journal of molecular sciences, 2022-06, Vol.23 (13), p.7026

2022

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Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and Relaxation

Frontiers in physiology, 2016-12, Vol.7, p.562-562

2016

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In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood

Journal of the American Heart Association, 2017-04, Vol.6 (4)

2017

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Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

Nature communications, 2016-02, Vol.7 (1), p.10794-10794, Article 10794

2016

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Interleukin-27 Gene Therapy Prevents the Development of Autoimmune Encephalomyelitis but Fails to Attenuate Established Inflammation due to the Expansion of CD11b + Gr-1 + Myeloid Cells

Frontiers in immunology, 2018-04, Vol.9, p.873-873

2018

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Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates

PloS one, 2012-06, Vol.7 (6), p.e38259

2012

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Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Journal of the American Heart Association, 2018-05, Vol.7 (10), p.n/a

2018

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Corrigendum: Muscle Twitch Kinetics Are Dependent on Muscle Group, Disease State, and Age in Duchenne Muscular Dystrophy Mouse Models

Frontiers in physiology, 2022-01, Vol.12, p.820245-820245

2022

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Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties

PloS one, 2014, Vol.9 (1), p.e86279-e86279

2014

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Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction

Frontiers in physiology, 2022-06, Vol.13, p.892979-892979

2022

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Muscle Twitch Kinetics Are Dependent on Muscle Group, Disease State, and Age in Duchenne Muscular Dystrophy Mouse Models

Frontiers in physiology, 2020-09, Vol.11, p.568909-568909

2020

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IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy

JCI insight, 2018-04, Vol.3 (7)

2018

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Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function

Biophysical journal, 2016-05, Vol.110 (9), p.2094-2105

2016

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Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature

The Journal of general physiology, 2013-01, Vol.141 (1), p.133-139

2013

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The Rates of Ca2+ Dissociation and Cross-bridge Detachment from Ventricular Myofibrils as Reported by a Fluorescent Cardiac Troponin C

The Journal of biological chemistry, 2012-08, Vol.287 (33), p.27930-27940

2012

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Molecular Insights into the MLCK Activation by CaM

Journal of chemical information and modeling, 2023-12, Vol.63 (23), p.7487-7498

2023

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Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C

Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure–Activity Relationship

NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling

Binding of calcium and magnesium to human cardiac troponin C

Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure

Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy

NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model

Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function

Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

Myofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and Relaxation

In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

Interleukin-27 Gene Therapy Prevents the Development of Autoimmune Encephalomyelitis but Fails to Attenuate Established Inflammation due to the Expansion of CD11b + Gr-1 + Myeloid Cells

Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin‐Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia

Corrigendum: Muscle Twitch Kinetics Are Dependent on Muscle Group, Disease State, and Age in Duchenne Muscular Dystrophy Mouse Models

Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties

Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction

Muscle Twitch Kinetics Are Dependent on Muscle Group, Disease State, and Age in Duchenne Muscular Dystrophy Mouse Models

IL-27 gene therapy induces depletion of Tregs and enhances the efficacy of cancer immunotherapy

Effects of Modified Parvalbumin EF-Hand Motifs on Cardiac Myocyte Contractile Function

Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature

The Rates of Ca2+ Dissociation and Cross-bridge Detachment from Ventricular Myofibrils as Reported by a Fluorescent Cardiac Troponin C

Molecular Insights into the MLCK Activation by CaM

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