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Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

Organic letters, 2014-08, Vol.16 (16), p.4094-4097

2014

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Formal Synthesis of Merrilactone A Using a Domino Cyanide 1,4-Addition–Aldol Cyclization

Organic letters, 2012-07, Vol.14 (14), p.3720-3723

2012

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Tricyclic IndazolesA Novel Class of Selective Estrogen Receptor Degrader Antagonists

Journal of medicinal chemistry, 2019-02, Vol.62 (3), p.1593-1608

2019

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Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

Bioorganic & medicinal chemistry letters, 2012-06, Vol.22 (12), p.3873-3878

2012

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Stereocontrolled Total Synthesis of (−)-Callipeltoside A

Organic letters, 2003-11, Vol.5 (23), p.4477-4480

2003

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Total Synthesis of the Callipeltoside Aglycon

Angewandte Chemie (International ed.), 2001-02, Vol.40 (3), p.603-607

2001

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Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

Journal of medicinal chemistry, 2014-07, Vol.57 (14), p.6128-6140

2014

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Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat

ACS medicinal chemistry letters, 2016-01, Vol.7 (1), p.94-99

2016

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Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B‑Cell Lymphoma

Journal of medicinal chemistry, 2017-12, Vol.60 (24), p.10071-10091

2017

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The first intramolecular silene Diels-Alder reactions

Chemical communications (Cambridge, England), 2014-01, Vol.50 (22), p.2919-2921

2014

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Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.3187-3197

2017

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Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687)

Journal of medicinal chemistry, 2012-12, Vol.55 (23), p.10610-10629

2012

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Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88 L265P Diffuse Large B-Cell Lymphoma

Journal of medicinal chemistry, 2017-12, Vol.60 (24), p.10071-10091

2017

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Synthesis of 8-substituted-6-phenyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolines using Pictet-Spengler and Bischler-Napieralski cyclisation methods

Tetrahedron letters, 2018-07, Vol.59 (30), p.2917-2920

2018

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Synthesis of novel, functionalised tricycles utilising the interrupted Pummerer reaction

Tetrahedron letters, 2016-01, Vol.57 (1), p.152-154

2016

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The first intramolecular silene Diels-Alder reactionsElectronic supplementary information (ESI) available: Experimental procedures and spectra of cycloadducts 14, 20-25. See DOI: 10.1039/c3cc49526d

2014-02

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ChemInform Abstract: Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

ChemInform, 2014-12, Vol.45 (51), p.no-no

2014

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ChemInform Abstract: Synthesis of Novel, Functionalized Tricycles Utilizing the Interrupted Pummerer Reaction

ChemInform, 2016-04, Vol.47 (18), p.no-no

2016

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Matched triplicate design sets in the optimisation of glucokinase activators – maximising medicinal chemistry information content

MedChemComm, 2013, Vol.4 (4), p.657

2013

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Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets – the discovery of AZD3651 and AZD9485

MedChemComm, 2013, Vol.4 (4), p.663

2013

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Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1

MedChemComm, 2013, Vol.4 (1), p.151-158

2013

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Dyspnea-Related Cues Engage the Prefrontal Cortex

Chest, 2015-10, Vol.148 (4), p.953-961

2015

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Matched triplicate design sets in the optimisation of glucokinase activators - maximising medicinal chemistry information contentElectronic supplementary information (ESI) available: References for experimental protocols, full data for the compounds summarised in Table 3 and the X-ray crystallography protocol. See DOI: 10.1039/c3md20367k

2013-03

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ChemInform Abstract: The First Intramolecular Silene Diels-Alder Reactions

ChemInform, 2014-07, Vol.45 (28), p.no-no

2014

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Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

Formal Synthesis of Merrilactone A Using a Domino Cyanide 1,4-Addition–Aldol Cyclization

Tricyclic IndazolesA Novel Class of Selective Estrogen Receptor Degrader Antagonists

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes

Stereocontrolled Total Synthesis of (−)-Callipeltoside A

Total Synthesis of the Callipeltoside Aglycon

Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B‑Cell Lymphoma

The first intramolecular silene Diels-Alder reactions

Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy

Design and Optimization of Pyrazinecarboxamide-Based Inhibitors of Diacylglycerol Acyltransferase 1 (DGAT1) Leading to a Clinical Candidate Dimethylpyrazinecarboxamide Phenylcyclohexylacetic Acid (AZD7687)

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88 L265P Diffuse Large B-Cell Lymphoma

Synthesis of 8-substituted-6-phenyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolines using Pictet-Spengler and Bischler-Napieralski cyclisation methods

Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity

Synthesis of novel, functionalised tricycles utilising the interrupted Pummerer reaction

The first intramolecular silene Diels-Alder reactionsElectronic supplementary information (ESI) available: Experimental procedures and spectra of cycloadducts 14, 20-25. See DOI: 10.1039/c3cc49526d

ChemInform Abstract: Cubanes in Medicinal Chemistry: Synthesis of Functionalized Building Blocks

ChemInform Abstract: Synthesis of Novel, Functionalized Tricycles Utilizing the Interrupted Pummerer Reaction

Matched triplicate design sets in the optimisation of glucokinase activators – maximising medicinal chemistry information content

Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets – the discovery of AZD3651 and AZD9485

Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1

Dyspnea-Related Cues Engage the Prefrontal Cortex

ChemInform Abstract: The First Intramolecular Silene Diels-Alder Reactions

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