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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (25), p.8754-8759

2008

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Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1: Design, Synthesis, and Preclinical Characterization

Journal of medicinal chemistry, 2004-07, Vol.47 (14), p.3491-3494

2004

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Mechanism of Inactivation of Plasminogen Activator Inhibitor-1 by a Small Molecule Inhibitor

The Journal of biological chemistry, 2007-03, Vol.282 (12), p.9288-9296

2007

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Modulation of adipose tissue development by pharmacological inhibition of PAI-1

Arteriosclerosis, thrombosis, and vascular biology, 2006-10, Vol.26 (10), p.2209

2006

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Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling

Arteriosclerosis, thrombosis, and vascular biology, 2005-02, Vol.25 (2), p.365

2005

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Effects of Pharmacological Inhibition and Genetic Deficiency of Plasminogen Activator Inhibitor-1 in Radiation-Induced Intestinal Injury

International journal of radiation oncology, biology, physics, 2009-07, Vol.74 (3), p.942-948

2009

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Rotigaptide (ZP123) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs

The Journal of pharmacology and experimental therapeutics, 2006-04, Vol.317 (1), p.236

2006

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Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

The Journal of pharmacology and experimental therapeutics, 2008-02, Vol.324 (2), p.497

2008

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Neutralization of Plasminogen Activator Inhibitor I (PAI-1) by the Synthetic Antagonist PAI-749 via a Dual Mechanism of Action

Molecular pharmacology, 2007-10, Vol.72 (4), p.897-906

2007

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Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis

Thrombosis and haemostasis, 2006-03, Vol.95 (3), p.469

2006

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Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis

The Journal of pharmacology and experimental therapeutics, 2005-08, Vol.314 (2), p.710

2005

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Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1

Bioorganic & medicinal chemistry letters, 2005-08, Vol.15 (15), p.3514-3518

2005

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A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives

Microcirculation (New York, N.Y. 1994), 1997-06, Vol.4 (2), p.211-232

1997

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Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3477-3480

2004

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Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (12), p.3742-3745

2010

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p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine

The Journal of pharmacology and experimental therapeutics, 2008-07, Vol.326 (1), p.144

2008

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Development of a human adipocyte synthetic polymer scaffold

Plastic and reconstructive surgery (1963), 1999-11, Vol.104 (6), p.1732-1738

1999

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Autocrine Regulation of Human Preadipocyte Migration by Plasminogen Activator Inhibitor-1

The journal of clinical endocrinology and metabolism, 2000-07, Vol.85 (7), p.2609-2614

2000

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Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function

The Journal of biological chemistry, 2003-05, Vol.278 (18), p.16329-16335

2003

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Angiotensin II Receptors in Human Preadipocytes: Role in Cell Cycle Regulation

Endocrinology (Philadelphia), 1999-01, Vol.140 (1), p.154-158

1999

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Role of the V1 vasopressin receptor in pressure overload-induced cardiac hypertrophy

Journal of molecular and cellular cardiology, 2007-06, Vol.42 (6), p.S32-S32

2007

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Synthesis and Secretion of Plasminogen Activator Inhibitor-1 by Human Preadipocytes

The journal of clinical endocrinology and metabolism, 1999-09, Vol.84 (9), p.3222-3227

1999

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PAI-1 inhibition and obesity: structural complexities and biological hurdles

Future lipidology, 2007-02, Vol.2 (1), p.5-8

Crandall, David L

2007

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WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation

Biochemical and biophysical research communications, 2003-11, Vol.311 (4), p.904-908

2003

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Effect of pharmacologic plasminogen activator inhibitor‐1 inhibition on cell motility and tumor angiogenesis

Journal of thrombosis and haemostasis, 2006-12, Vol.4 (12), p.2710-2715

2006

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Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade

Tiplaxtinin, a Novel, Orally Efficacious Inhibitor of Plasminogen Activator Inhibitor-1: Design, Synthesis, and Preclinical Characterization

Mechanism of Inactivation of Plasminogen Activator Inhibitor-1 by a Small Molecule Inhibitor

Modulation of adipose tissue development by pharmacological inhibition of PAI-1

Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling

Effects of Pharmacological Inhibition and Genetic Deficiency of Plasminogen Activator Inhibitor-1 in Radiation-Induced Intestinal Injury

Rotigaptide (ZP123) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs

Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] in vitro and in rodent models of vascular inflammation and thrombosis

Neutralization of Plasminogen Activator Inhibitor I (PAI-1) by the Synthetic Antagonist PAI-749 via a Dual Mechanism of Action

Pharmacologic inhibition of platelet vWF-GPIb alpha interaction prevents coronary artery thrombosis

Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis

Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1

A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives

Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1

Synthesis and evaluation of azabicyclo[3.2.1]octane derivatives as potent mixed vasopressin antagonists

p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine

Development of a human adipocyte synthetic polymer scaffold

Autocrine Regulation of Human Preadipocyte Migration by Plasminogen Activator Inhibitor-1

Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function

Angiotensin II Receptors in Human Preadipocytes: Role in Cell Cycle Regulation

Role of the V1 vasopressin receptor in pressure overload-induced cardiac hypertrophy

Synthesis and Secretion of Plasminogen Activator Inhibitor-1 by Human Preadipocytes

PAI-1 inhibition and obesity: structural complexities and biological hurdles

WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation

Effect of pharmacologic plasminogen activator inhibitor‐1 inhibition on cell motility and tumor angiogenesis

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