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Variant Classification Discordance: Contributing Factors and Predictive Models

The Journal of molecular diagnostics : JMD, 2024-02, Vol.26 (2), p.115-126

2024

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Mutually exclusive mutation profiles define functionally related genes in muscle invasive bladder cancer

PloS one, 2022-01, Vol.17 (1), p.e0259992-e0259992

2022

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Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit

PloS one, 2013-12, Vol.8 (12), p.e85859

2013

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EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

BMC cancer, 2012-03, Vol.12 (1), p.91-91, Article 91

2012

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Secreted phospholipases A2 of snake venoms: effects on the peripheral neuromuscular system with comments on the role of phospholipases A2 in disorders of the CNS and their uses in industry

Toxins, 2013-12, Vol.5 (12), p.2533-2571

2013

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Identification and characterization of a novel nuclear structure containing members of the homologous recombination and DNA damage response pathways

Cancer genetics, 2018-12, Vol.228-229, p.98-109

2018

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BRCA1 Variant Assessment Using a Simple Analytic Assay

The journal of applied laboratory medicine, 2022-05, Vol.7 (3), p.674-688

2022

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Future Role of Health Technology Assessment for Genomic Medicine in Oncology: A Canadian Laboratory Perspective

Current oncology (Toronto), 2023-10, Vol.30 (11), p.9660-9669

2023

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Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling

PloS one, 2015-12, Vol.10 (12), p.e0144434-e0144434

2015

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BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development

PloS one, 2014-06, Vol.9 (6), p.e100068

2014

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The Rad9A checkpoint protein is required for nuclear localization of the claspin adaptor protein

Cell cycle (Georgetown, Tex.), 2010-02, Vol.9 (3), p.548-556

2010

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Variant Classification Discordance

The Journal of molecular diagnostics : JMD, 2024-02, Vol.26 (2), p.115-126

2024

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Ultrastructural evidence for the uptake of a neurotoxic snake venom phospholipase A2 into mammalian motor nerve terminals

Experimental neurology, 2009-10, Vol.219 (2), p.591-594

2009

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Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

Nature (London), 1993-05, Vol.363 (6427), p.368-371

1993

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Neuromuscular toxicology of the venom of Collett's snake (Pseudechis colletti): A histopathological study

Muscle & nerve, 2011-04, Vol.43 (4), p.552-559

2011

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A Role for the Phosphorylation of hRad9 in Checkpoint Signaling

The Journal of biological chemistry, 2003-07, Vol.278 (29), p.26620-26628

2003

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Tri-cistronic cloning, overexpression and purification of human Rad9, Rad1, Hus1 protein complex

Protein expression and purification, 2007-08, Vol.54 (2), p.204-211

2007

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DNA Damage-dependent and -independent Phosphorylation of the hRad9 Checkpoint Protein

The Journal of biological chemistry, 2001-11, Vol.276 (45), p.41898-41905

2001

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A Human Homolog of the Schizosaccharomyces pombe rad9+Checkpoint Control Gene

Proceedings of the National Academy of Sciences - PNAS, 1996-11, Vol.93 (24), p.13890-13895

1996

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Fission yeast Uve1 and Apn2 function in distinct oxidative damage repair pathways in vivo

DNA repair, 2003-11, Vol.2 (11), p.1253-1267

2003

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Fission Yeast rad12 +Regulates Cell Cycle Checkpoint Control and Is Homologous to the Bloom’s Syndrome Disease Gene

Molecular and Cellular Biology, 1998-05, Vol.18 (5), p.2721-2728

1998

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Abstract 1931: Development of a functional assay for the determination of BRCA1 carrier status

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.1931-1931

2013

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Abstract 693: Development of a protein-based functional assay for the determination of BRCA1 carrier status

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.693-693

2012

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Eligibility Criteria and Genetic Testing Results from a High-Risk Cohort for Hereditary Breast and Ovarian Cancer Syndrome in Southeastern Ontario

The Journal of molecular diagnostics : JMD, 2016-05, Vol.18 (3), p.362-369

2016

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Mammalian Rad9 Plays a Role in Telomere Stability, S- and G 2 -Phase-Specific Cell Survival, and Homologous Recombinational Repair

Molecular and cellular biology, 2006-03, Vol.26 (5), p.1850-1864

2006

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Variant Classification Discordance: Contributing Factors and Predictive Models

Mutually exclusive mutation profiles define functionally related genes in muscle invasive bladder cancer

Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

Secreted phospholipases A2 of snake venoms: effects on the peripheral neuromuscular system with comments on the role of phospholipases A2 in disorders of the CNS and their uses in industry

Identification and characterization of a novel nuclear structure containing members of the homologous recombination and DNA damage response pathways

BRCA1 Variant Assessment Using a Simple Analytic Assay

Future Role of Health Technology Assessment for Genomic Medicine in Oncology: A Canadian Laboratory Perspective

Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling

BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development

The Rad9A checkpoint protein is required for nuclear localization of the claspin adaptor protein

Variant Classification Discordance

Ultrastructural evidence for the uptake of a neurotoxic snake venom phospholipase A2 into mammalian motor nerve terminals

Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

Neuromuscular toxicology of the venom of Collett's snake (Pseudechis colletti): A histopathological study

A Role for the Phosphorylation of hRad9 in Checkpoint Signaling

Tri-cistronic cloning, overexpression and purification of human Rad9, Rad1, Hus1 protein complex

DNA Damage-dependent and -independent Phosphorylation of the hRad9 Checkpoint Protein

A Human Homolog of the Schizosaccharomyces pombe rad9+Checkpoint Control Gene

Fission yeast Uve1 and Apn2 function in distinct oxidative damage repair pathways in vivo

Fission Yeast rad12 +Regulates Cell Cycle Checkpoint Control and Is Homologous to the Bloom’s Syndrome Disease Gene

Abstract 1931: Development of a functional assay for the determination of BRCA1 carrier status

Abstract 693: Development of a protein-based functional assay for the determination of BRCA1 carrier status

Eligibility Criteria and Genetic Testing Results from a High-Risk Cohort for Hereditary Breast and Ovarian Cancer Syndrome in Southeastern Ontario

Mammalian Rad9 Plays a Role in Telomere Stability, S- and G 2 -Phase-Specific Cell Survival, and Homologous Recombinational Repair

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