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A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast Cancer

Pharmaceutics, 2024-04, Vol.16 (4), p.536

2024

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A Facile Asymmetric Synthesis of Either Enantiomer of 2-Substituted Pyrrolidines

Journal of organic chemistry, 2010-04, Vol.75 (7), p.2236-2246

2010

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Overexpression of Mcl-1 confers multidrug resistance, whereas topoisomerase IIβ downregulation introduces mitoxantrone-specific drug resistance in acute myeloid leukemia

Molecular pharmacology, 2013-08, Vol.84 (2), p.236-243

2013

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miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells

Breast cancer research : BCR, 2016-04, Vol.18 (1), p.40-40, Article 40

2016

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Putative Identification of New Phragmaline-Type Limonoids from the Leaves of Swietenia macrophylla King: A Case Study Using Mass Spectrometry-Based Molecular Networking

Molecules (Basel, Switzerland), 2023-11, Vol.28 (22), p.7603

2023

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Structure–Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and Its Analogues

Journal of medicinal chemistry, 2011-08, Vol.54 (16), p.5937-5948

2011

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Untargeted-based metabolomics analysis and in vitro/in silico antiviral activity of extracts from Phyllanthus brasiliensis (Aubl.) Poir

Phytochemical analysis, 2023-10, Vol.34 (7), p.869-883

2023

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sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell

Cancer letters, 2008-02, Vol.259 (2), p.198-208

2008

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Structure−Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4H-chromene-3-carboxylate (sHA 14-1) and Its Analogues

Journal of medicinal chemistry, 2009-10, Vol.52 (19), p.5937-5949

2009

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Ethyl 2‑Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)‑4H‑chromene-3-carboxylate (CXL017): A Novel Scaffold That Resensitizes Multidrug Resistant Leukemia Cells to Chemotherapy

ACS chemical biology, 2013-02, Vol.8 (2), p.327-335

2013

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Abstract 23: Antibody targeting of ADAM8 for treatment of triple-negative breast cancer

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.23-23

2017

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Abstract 6639: SRF617, a potent enzymatic inhibitor of CD39, demonstrates single-agent activity and cooperates with various cancer therapies in both solid tumor and hematologic malignancies

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6639-6639

2020

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Characterization of a tetrameric proanthocyanidin in Stryphnodendron pulcherrimum and an overview on potential health benefits of condensed tannins via interaction with gut microbiota

Journal of functional foods, 2023-10, Vol.109, p.105801, Article 105801

2023

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Abstract 1137: ADAM8 drives aggressive phenotype of triple-negative inflammatory breast cancer & constitutes a novel therapeutic target

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1137-1137

2017

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Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4 H -chromene-3-carboxylate (CXL017): A Novel Scaffold That Resensitizes Multidrug Resistant Leukemia Cells to Chemotherapy

ACS chemical biology, 2013-02, Vol.8 (2), p.327-335

2013

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Abstract B166: MicroRNAs downstream of ADAM8 as therapeutic targets and non-invasive biomarkers for triple-negative breast cancer

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.B166-B166

2013

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Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) – a novel scaffold that re-sensitizes multidrug resistant leukemia cells to chemotherapy

ACS chemical biology, 2012-11, Vol.8 (2), p.327-335

2012

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Structure–Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4 H -chromene-3-carboxylate (CXL017) and Its Analogues

Journal of medicinal chemistry, 2011-08, Vol.54 (16), p.5937-5948

2011

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Putative Identification of New Phragmaline-Type Limonoids from the Leaves of ISwietenia macrophylla/I King: A Case Study Using Mass Spectrometry-Based Molecular Networking

Molecules (Basel, Switzerland), 2023-11, Vol.28 (22)

2023

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Structure−Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4 H -chromene-3-carboxylate (sHA 14-1) and Its Analogues

Journal of medicinal chemistry, 2009-10, Vol.52 (19), p.5937-5949

2009

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Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

The New England journal of medicine, 2023-12, Vol.389 (24), p.2233-2244

2023

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From waste management to circular economy: Leveraging thermophiles for sustainable growth and global resource optimization

Journal of environmental management, 2024-06, Vol.360, p.121136-121136, Article 121136

2024

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A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors

Nature communications, 2018-03, Vol.9 (1), p.1199-15, Article 1199

2018

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Pulmonary Hypertension Associated with Hypoxic-Ischemic Encephalopathy—Antecedent Characteristics and Comorbidities

The Journal of pediatrics, 2018-05, Vol.196, p.45-51.e3

2018

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Effect of dopants and microstructure on the electrochemical cyclic stability of layered P2-type Na0.67MnO2 prepared by different chemical routes: An experimental and theoretical study

Ceramics international, 2023-02, Vol.49 (4), p.6654-6665

2023

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A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast Cancer

A Facile Asymmetric Synthesis of Either Enantiomer of 2-Substituted Pyrrolidines

Overexpression of Mcl-1 confers multidrug resistance, whereas topoisomerase IIβ downregulation introduces mitoxantrone-specific drug resistance in acute myeloid leukemia

miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells

Putative Identification of New Phragmaline-Type Limonoids from the Leaves of Swietenia macrophylla King: A Case Study Using Mass Spectrometry-Based Molecular Networking

Structure–Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and Its Analogues

Untargeted-based metabolomics analysis and in vitro/in silico antiviral activity of extracts from Phyllanthus brasiliensis (Aubl.) Poir

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell

Structure−Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4H-chromene-3-carboxylate (sHA 14-1) and Its Analogues

Ethyl 2‑Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)‑4H‑chromene-3-carboxylate (CXL017): A Novel Scaffold That Resensitizes Multidrug Resistant Leukemia Cells to Chemotherapy

Abstract 23: Antibody targeting of ADAM8 for treatment of triple-negative breast cancer

Abstract 6639: SRF617, a potent enzymatic inhibitor of CD39, demonstrates single-agent activity and cooperates with various cancer therapies in both solid tumor and hematologic malignancies

Characterization of a tetrameric proanthocyanidin in Stryphnodendron pulcherrimum and an overview on potential health benefits of condensed tannins via interaction with gut microbiota

Abstract 1137: ADAM8 drives aggressive phenotype of triple-negative inflammatory breast cancer & constitutes a novel therapeutic target

Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4 H -chromene-3-carboxylate (CXL017): A Novel Scaffold That Resensitizes Multidrug Resistant Leukemia Cells to Chemotherapy

Abstract B166: MicroRNAs downstream of ADAM8 as therapeutic targets and non-invasive biomarkers for triple-negative breast cancer

Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) – a novel scaffold that re-sensitizes multidrug resistant leukemia cells to chemotherapy

Structure–Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4 H -chromene-3-carboxylate (CXL017) and Its Analogues

Putative Identification of New Phragmaline-Type Limonoids from the Leaves of ISwietenia macrophylla/I King: A Case Study Using Mass Spectrometry-Based Molecular Networking

Structure−Activity Relationship and Molecular Mechanisms of Ethyl 2-Amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4 H -chromene-3-carboxylate (sHA 14-1) and Its Analogues

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

From waste management to circular economy: Leveraging thermophiles for sustainable growth and global resource optimization

A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors

Pulmonary Hypertension Associated with Hypoxic-Ischemic Encephalopathy—Antecedent Characteristics and Comorbidities

Effect of dopants and microstructure on the electrochemical cyclic stability of layered P2-type Na0.67MnO2 prepared by different chemical routes: An experimental and theoretical study

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