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Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans

Drug metabolism and disposition, 2014-12, Vol.42 (12), p.2016-2022

2014

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Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

Annual review of pharmacology and toxicology, 2021-01, Vol.61 (1), p.225-245

2021

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Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment

Alimentary pharmacology & therapeutics, 2021-08, Vol.54 (4), p.388-401

2021

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Diagnosing an overcrowded emergency department from its Electronic Health Records

Scientific reports, 2024-04, Vol.14 (1), p.9955-9955, Article 9955

2024

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The Impact of Formulation, Delivery, and Dosing Regimen on the Risk of Drug–Drug Interactions

Clinical pharmacology and therapeutics, 2019-06, Vol.105 (6), p.1329-1331

2019

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A latent variable approach to account for correlated inputs in global sensitivity analysis

Journal of pharmacokinetics and pharmacodynamics, 2021-10, Vol.48 (5), p.671-686

2021

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Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria

European journal of pharmaceutical sciences, 2017-11, Vol.109, p.111-120

2017

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Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance

The Journal of pharmacology and experimental therapeutics, 2019-02, Vol.368 (2), p.157-168

2019

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The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

Pharmaceutical research, 2015-12, Vol.32 (12), p.3927-3936

2015

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Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

The AAPS journal, 2016-03, Vol.18 (2), p.321-332

2016

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The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall

European journal of pharmaceutical sciences, 2019-04, Vol.131, p.195-207

2019

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Exploring the discrepancies between clinical trials and real‐world data: A small‐cell lung cancer study

Clinical and translational science, 2024-08, Vol.17 (8), p.e13909-n/a

2024

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Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

Molecular pharmaceutics, 2021-08, Vol.18 (8), p.2997-3009

2021

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Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution

The AAPS journal, 2020-02, Vol.22 (2), p.41, Article 41

2020

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Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics

Journal of pharmacokinetics and pharmacodynamics, 2019-04, Vol.46 (2), p.137-154

2019

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A novel analytical framework for risk stratification of real‐world data using machine learning: A small cell lung cancer study

Clinical and translational science, 2022-10, Vol.15 (10), p.2437-2447

2022

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Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease

Therapeutic drug monitoring, 2023-12, Vol.45 (6), p.743

2023

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A hybrid modeling approach to simulate complex systems and classify behaviors

Network modeling and analysis in health informatics and bioinformatics (Wien), 2024-03, Vol.13 (1), p.9, Article 9

2024

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Simultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss Approach

Drug metabolism and disposition, 2018-04, Vol.46 (4), p.405-414

2018

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Implications of intercorrelation between hepatic CYP3A4‐CYP2C8 enzymes for the evaluation of drug–drug interactions: a case study with repaglinide

British journal of clinical pharmacology, 2018-05, Vol.84 (5), p.972-986

2018

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Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective

European journal of pharmaceutical sciences, 2022-05, Vol.172, p.106100, Article 106100

2022

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Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I–IV drugs

Journal of pharmacokinetics and pharmacodynamics, 2019-02, Vol.46 (1), p.27-42

2019

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Application of Process Mining for Modelling Small Cell Lung Cancer Prognosis

Studies in health technology and informatics, 2023-05, Vol.302, p.18

2023

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Drug disposition and modelling before and after gastric bypass: immediate and controlled‐release metoprolol formulations

British journal of clinical pharmacology, 2015-11, Vol.80 (5), p.1021-1030

2015

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Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis

Pharmaceutics, 2024-05, Vol.16 (6), p.702

2024

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Meta-analysis of the turnover of intestinal epithelia in preclinical animal species and humans

Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

Review article: time to revisit Child‐Pugh score as the basis for predicting drug clearance in hepatic impairment

Diagnosing an overcrowded emergency department from its Electronic Health Records

The Impact of Formulation, Delivery, and Dosing Regimen on the Risk of Drug–Drug Interactions

A latent variable approach to account for correlated inputs in global sensitivity analysis

Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria

Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance

The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall

Exploring the discrepancies between clinical trials and real‐world data: A small‐cell lung cancer study

Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats

Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution

Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics

A novel analytical framework for risk stratification of real‐world data using machine learning: A small cell lung cancer study

Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease

A hybrid modeling approach to simulate complex systems and classify behaviors

Simultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss Approach

Implications of intercorrelation between hepatic CYP3A4‐CYP2C8 enzymes for the evaluation of drug–drug interactions: a case study with repaglinide

Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective

Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS I–IV drugs

Application of Process Mining for Modelling Small Cell Lung Cancer Prognosis

Drug disposition and modelling before and after gastric bypass: immediate and controlled‐release metoprolol formulations

Population Pharmacokinetic Analysis and Simulation of Alternative Dosing Regimens for Biosimilars to Adalimumab and Etanercept in Patients with Rheumatoid Arthritis

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