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The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance

British journal of pharmacology, 2010-01, Vol.159 (1), p.49-57

Darpo, B

2010

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Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects

The American heart journal, 2012-06, Vol.163 (6), p.912-930

2012

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Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

Clinical pharmacology and therapeutics, 2015-04, Vol.97 (4), p.326-335

2015

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Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes

European heart journal supplements, 2001-09, Vol.3 (suppl-K), p.K70-K80

DARPO, B

2001

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Detection of QTc Effects in Small Studies-Implications for Replacing the Thorough QT Study

Annals of noninvasive electrocardiology, 2015-07, Vol.20 (4), p.368-377

2015

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The effect of oral magnesium, alone or as an adjuvant to sotalol, after cardioversion in patients with persistent atrial fibrillation

European heart journal, 2000-07, Vol.21 (14), p.1177-1185

2000

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Current challenges and opportunities in cardiac safety: a clinical perspective

Toxicology letters, 2018-10, Vol.295, p.S48-S48

Darpo, B.

2018

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Detection and reporting of drug-induced proarrhythmias: room for improvement

Europace (London, England), 2007-09, Vol.9 Suppl 4 (Supplement 4), p.iv23-iv36

Darpo, B.

2007

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Modification of atrioventricular conduction as adjunct therapy for pacemaker-treated patients with hypertrophic obstructive cardiomyopathy

European heart journal, 1998-01, Vol.19 (1), p.132-138

1998

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Reduction in sympathetic activity after long-term CPAP treatment in sleep apnoea: cardiovascular implications

The European respiratory journal, 1995-02, Vol.8 (2), p.222-229

1995

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Comparison of Manual and Automated Measurements of the QT Interval in Healthy Volunteers: An Analysis of Five Thorough QT Studies

Clinical pharmacology and therapeutics, 2009-11, Vol.86 (5), p.503-506

2009

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The New S7B/E14 Question and Answer Draft Guidance for Industry: Contents and Commentary

Journal of clinical pharmacology, 2021-10, Vol.61 (10), p.1261-1273

2021

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Prospective study of left ventricular function after radiofrequency ablation of atrioventricular junction in patients with atrial fibrillation

British Heart Journal, 1995-09, Vol.74 (3), p.261-267

1995

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Effect of lofexidine on cardiac repolarization during treatment of opioid withdrawal

Drug and alcohol dependence, 2019-12, Vol.205, p.107596-107596, Article 107596

2019

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Assessment of accessory pathway and atrial refractoriness by transoesophageal and intracardiac atrial stimulation: an analysis of methodological agreement

Europace (London, England), 1999-01, Vol.1 (1), p.55-62

1999

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Design of the "Thorough QT Study"

Clinical pharmacology and therapeutics, 2008-04, Vol.83 (4), p.529-529

2008

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Mortality and ventricular arrhythmias in patients with atrial fibrillation on sotalol

Europace (London, England), 2023-05, Vol.25 (Supplement_1)

2023

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Implications of the IQ-CSRC Prospective Study: Time to Revise ICH E14

Drug safety, 2015-09, Vol.38 (9), p.773-780

2015

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Early QT assessment – how can our confidence in the data be improved?

British journal of clinical pharmacology, 2013-11, Vol.76 (5), p.642-648

2013

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International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug‐induced torsades de pointes

British journal of pharmacology, 2008-08, Vol.154 (7), p.1491-1501

2008

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Lomitapide at Supratherapeutic Plasma Levels Does Not Prolong the QTc Interval-Results from a TQT Study with Moxifloxacin and Ketoconazole

Annals of noninvasive electrocardiology, 2013-11, Vol.18 (6), p.577-589

2013

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Diurnal QT analysis in patients with sotalol after cardioversion of atrial fibrillation

Annals of noninvasive electrocardiology, 2021-07, Vol.26 (4), p.e12834-n/a

2021

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Oritavancin, a New Lipoglycopeptide Antibiotic: Results From a Thorough QT Study

Journal of clinical pharmacology, 2010-08, Vol.50 (8), p.895-903

2010

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Drug-induced arrhythmia a difficult to catch adverse effect. New guidelines for increased cardiovascular safety

Läkartidningen, 2006-04, Vol.103 (14), p.1094

Darpö, Börje

2006

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Torsades de pointes induced by transesophageal atrial stimulation after administration of almokalant

International journal of cardiology, 1996-03, Vol.53 (3), p.311-313

1996

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The thorough QT/QTc study 4 years after the implementation of the ICH E14 guidance

Methodologies to characterize the QT/corrected QT interval in the presence of drug-induced heart rate changes or other autonomic effects

Results From the IQ-CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase

Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes

Detection of QTc Effects in Small Studies-Implications for Replacing the Thorough QT Study

The effect of oral magnesium, alone or as an adjuvant to sotalol, after cardioversion in patients with persistent atrial fibrillation

Current challenges and opportunities in cardiac safety: a clinical perspective

Detection and reporting of drug-induced proarrhythmias: room for improvement

Modification of atrioventricular conduction as adjunct therapy for pacemaker-treated patients with hypertrophic obstructive cardiomyopathy

Reduction in sympathetic activity after long-term CPAP treatment in sleep apnoea: cardiovascular implications

Comparison of Manual and Automated Measurements of the QT Interval in Healthy Volunteers: An Analysis of Five Thorough QT Studies

The New S7B/E14 Question and Answer Draft Guidance for Industry: Contents and Commentary

Prospective study of left ventricular function after radiofrequency ablation of atrioventricular junction in patients with atrial fibrillation

Effect of lofexidine on cardiac repolarization during treatment of opioid withdrawal

Assessment of accessory pathway and atrial refractoriness by transoesophageal and intracardiac atrial stimulation: an analysis of methodological agreement

Design of the "Thorough QT Study"

Mortality and ventricular arrhythmias in patients with atrial fibrillation on sotalol

Implications of the IQ-CSRC Prospective Study: Time to Revise ICH E14

Early QT assessment – how can our confidence in the data be improved?

International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug‐induced torsades de pointes

Lomitapide at Supratherapeutic Plasma Levels Does Not Prolong the QTc Interval-Results from a TQT Study with Moxifloxacin and Ketoconazole

Diurnal QT analysis in patients with sotalol after cardioversion of atrial fibrillation

Oritavancin, a New Lipoglycopeptide Antibiotic: Results From a Thorough QT Study

Drug-induced arrhythmia a difficult to catch adverse effect. New guidelines for increased cardiovascular safety

Torsades de pointes induced by transesophageal atrial stimulation after administration of almokalant

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