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E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

Science (American Association for the Advancement of Science), 2009-08, Vol.325 (5944), p.1134-1138

2009

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Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

Proceedings of the National Academy of Sciences - PNAS, 2010-07, Vol.107 (29), p.12919-12924

2010

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The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

Molecular and Cellular Biology, 2012-04, Vol.32 (7), p.1248-1259

2012

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Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

The Journal of cell biology, 2010-12, Vol.191 (7), p.1395-1411

2010

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TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis

Molecular and Cellular Biology, 2013-02, Vol.33 (3), p.582-595

2013

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E2 interaction and dimerization in the crystal structure of TRAF6

Nature structural & molecular biology, 2009-06, Vol.16 (6), p.658-666

2009

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Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

Biochemistry (Easton), 2009-11, Vol.48 (44), p.10558-10567

2009

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Cthrc1 is a positive regulator of osteoblastic bone formation

PloS one, 2008-09, Vol.3 (9), p.e3174-e3174

2008

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The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL

The Journal of biological chemistry, 2008-09, Vol.283 (36), p.24871-24880

2008

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Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma

Cancer research (Chicago, Ill.), 2015-01, Vol.75 (2), p.316-329

2015

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TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1

Molecular and Cellular Biology, 2008-10, Vol.28 (20), p.6536-6546

2008

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Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response

The Journal of biological chemistry, 2011-09, Vol.286 (35), p.30806-30815

2011

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Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice

PloS one, 2012-12, Vol.7 (12), p.e51228

2012

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TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3

The Journal of biological chemistry, 2007-02, Vol.282 (6), p.3918-3928

2007

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A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1

Oncotarget, 2014-01, Vol.5 (1), p.224-236

2014

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Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

Molecular and Cellular Biology, 2008-12, Vol.28 (23), p.7081-7095

2008

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Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3

Science signaling, 2013-05, Vol.6 (275), p.ra35

2013

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Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of IκB Kinase Activation

The Journal of biological chemistry, 2007-02, Vol.282 (6), p.4102-4112

2007

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Dasatinib inhibits both osteoclast activation and prostate cancer PC-3 cell-induced osteoclast formation

Cancer biology & therapy, 2009-11, Vol.8 (22), p.2153-2159

2009

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Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and TGFβ-activated Kinase 1 (TAK1) Play Essential Roles in the C-type Lectin Receptor Signaling in Response to Candida albicans Infection

The Journal of biological chemistry, 2012-12, Vol.287 (53), p.44143-44150

2012

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Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides

Biochemical and biophysical research communications, 2007-08, Vol.359 (3), p.510-515

2007

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Nuclear Tumor Necrosis Factor Receptor-associated Factor 6 in Lymphoid Cells Negatively Regulates c-Myb-mediated Transactivation through Small Ubiquitin-related Modifier-1 Modification

The Journal of biological chemistry, 2008-02, Vol.283 (8), p.5081-5089

2008

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Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel

Cancer research (Chicago, Ill.), 2006-11, Vol.66 (22), p.10919-10928

2006

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TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation

Biochemical and biophysical research communications, 2007-08, Vol.359 (4), p.1044-1049

2007

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A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression

Molecular pharmacology, 2008-03, Vol.73 (3), p.919-929

2008

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E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis

E2 interaction and dimerization in the crystal structure of TRAF6

Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

Cthrc1 is a positive regulator of osteoblastic bone formation

The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL

Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma

TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1

Critical Role of Monoubiquitination of Histone H2AX Protein in Histone H2AX Phosphorylation and DNA Damage Response

Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice

TAK1-dependent Signaling Requires Functional Interaction with TAB2/TAB3

A TRAF2 binding independent region of TNFR2 is responsible for TRAF2 depletion and enhancement of cytotoxicity driven by TNFR1

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3

Site-specific Lys-63-linked Tumor Necrosis Factor Receptor-associated Factor 6 Auto-ubiquitination Is a Critical Determinant of IκB Kinase Activation

Dasatinib inhibits both osteoclast activation and prostate cancer PC-3 cell-induced osteoclast formation

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and TGFβ-activated Kinase 1 (TAK1) Play Essential Roles in the C-type Lectin Receptor Signaling in Response to Candida albicans Infection

Inhibition of RANKL-mediated osteoclast differentiation by selective TRAF6 decoy peptides

Nuclear Tumor Necrosis Factor Receptor-associated Factor 6 in Lymphoid Cells Negatively Regulates c-Myb-mediated Transactivation through Small Ubiquitin-related Modifier-1 Modification

Inhibition of prostate tumor growth and bone remodeling by the vascular targeting agent VEGF121/rGel

TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation

A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression

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