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Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

Journal of Virology, 2010-08, Vol.84 (15), p.7625-7633

2010

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Structure of Human Prostasin, a Target for the Regulation of Hypertension

The Journal of biological chemistry, 2008-12, Vol.283 (50), p.34864-34872

2008

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Host Cell Factor Requirement for Hepatitis C Virus Enzyme Maturation

Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (24), p.13931-13935

2001

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The Herpesvirus Proteases as Targets for Antiviral Chemotherapy

Antiviral Chemistry and Chemotherapy, 2000-01, Vol.11 (1), p.1-22

2000

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L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

Journal of medicinal chemistry, 1994-10, Vol.37 (21), p.3443-3451

1994

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Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4

The Journal of biological chemistry, 2015-08, Vol.290 (33), p.20360-20373

2015

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Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

Nature (London), 1989-02, Vol.337 (6208), p.615-620

1989

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Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met

The Journal of biological chemistry, 2011-04, Vol.286 (13), p.11218-11225

2011

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Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors

Journal of medicinal chemistry, 2000-09, Vol.43 (18), p.3386-3399

2000

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Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 Å resolution

Acta crystallographica. Section D, Biological crystallography., 2003-10, Vol.59 (10), p.1725-1730

2003

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Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation

Journal of medicinal chemistry, 1996-08, Vol.39 (17), p.3278-3290

1996

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Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

The Journal of biological chemistry, 2002-10, Vol.277 (41), p.38797-38802

2002

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Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates

Biochemistry (Easton), 1994-01, Vol.33 (1), p.98-105

1994

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3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors

Journal of medicinal chemistry, 1993, Vol.36 (2), p.292-294

1993

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Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands

Journal of medicinal chemistry, 1993-08, Vol.36 (16), p.2300-2310

1993

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Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases

Biochemistry (Easton), 2005-07, Vol.44 (27), p.9430-9440

2005

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Dimerization and Activation of the Herpes Simplex Virus Type 1 Protease

The Journal of biological chemistry, 1997-03, Vol.272 (12), p.7732-7735

1997

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A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity

Journal of medicinal chemistry, 1992-07, Vol.35 (14), p.2525-2533

1992

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Active Human Cytomegalovirus Protease Is a Dimer (∗)

The Journal of biological chemistry, 1996-03, Vol.271 (13), p.7445-7449

1996

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An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex

Journal of medicinal chemistry, 1997-08, Vol.40 (16), p.2440-2444

1997

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A collaborative screening program for the discovery of inhibitors of HCV NS2/3 cis-cleaving protease activity

Journal of biomolecular screening, 2002-04, Vol.7 (2), p.149-154

2002

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Activation of the Herpes Simplex Virus Type 1 Protease

The Journal of biological chemistry, 1995-09, Vol.270 (39), p.22697-22700

1995

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HIV Protease as an Inhibitor Target for the Treatment of AIDS

Advances in Pharmacology, 1994, Vol.25, p.399-454

1994

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A general procedure for the purification of human β-secretase expressed in Escherichia coli

Protein expression and purification, 2004-04, Vol.34 (2), p.190-196

2004

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Protein expression plasmids produced rapidly: streamlining cloning protocols and robotic handling

Assay and drug development technologies, 2005-12, Vol.3 (6), p.661-674

2005

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Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

Structure of Human Prostasin, a Target for the Regulation of Hypertension

Host Cell Factor Requirement for Hepatitis C Virus Enzyme Maturation

The Herpesvirus Proteases as Targets for Antiviral Chemotherapy

L-735,524: The Design of a Potent and Orally Bioavailable HIV Protease Inhibitor

Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

Structural Basis for Selective Small Molecule Kinase Inhibition of Activated c-Met

Identification of MK-944a: A Second Clinical Candidate from the Hydroxylaminepentanamide Isostere Series of HIV Protease Inhibitors

Structure of apo, unactivated insulin-like growth factor-1 receptor kinase at 1.5 Å resolution

Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation

Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity

Dissociation and association of the HIV-1 protease dimer subunits: Equilibria and rates

3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors

Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands

Biochemical and Structural Characterization of a Novel Class of Inhibitors of the Type 1 Insulin-like Growth Factor and Insulin Receptor Kinases

Dimerization and Activation of the Herpes Simplex Virus Type 1 Protease

A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity

Active Human Cytomegalovirus Protease Is a Dimer (∗)

An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex

A collaborative screening program for the discovery of inhibitors of HCV NS2/3 cis-cleaving protease activity

Activation of the Herpes Simplex Virus Type 1 Protease

HIV Protease as an Inhibitor Target for the Treatment of AIDS

A general procedure for the purification of human β-secretase expressed in Escherichia coli

Protein expression plasmids produced rapidly: streamlining cloning protocols and robotic handling

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