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Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

Medicinal research reviews, 2019-09, Vol.39 (5), p.1553-1602

2019

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New Benzophenone-Derived Bisphosphonium Salts as Leishmanicidal Leads Targeting Mitochondria through Inhibition of Respiratory Complex II

Journal of medicinal chemistry, 2010-02, Vol.53 (4), p.1788-1798

2010

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Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1509-1522

2017

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Antiprotozoal Activity and DNA Binding of Dicationic Acridones

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1940-1949

2015

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Bis(2-aminoimidazolines) and Bisguanidines: Synthetic Approaches, Antiparasitic Activity and DNA Binding Properties

Current medicinal chemistry, 2017-01, Vol.24 (33), p.3606-3632

2017

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Automated techniques in pKa determination: Low, medium and high-throughput screening methods

Drug discovery today. Technologies, 2018-07, Vol.27, p.49-58

Dardonville, Christophe

2018

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Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

International journal for parasitology -- drugs and drug resistance, 2016-04, Vol.6 (1), p.23-34

2016

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Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (14), p.4506-4516

2012

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SAR of 4‑Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase

ACS medicinal chemistry letters, 2018-09, Vol.9 (9), p.923-928

2018

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Aqueous pKa prediction for tautomerizable compounds using equilibrium bond lengths

Communications chemistry, 2020-02, Vol.3 (1), p.21-21, Article 21

2020

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Prediction of Aqueous pKa Values for Guanidine-Containing Compounds Using Ab Initio Gas-Phase Equilibrium Bond Lengths

ACS omega, 2018-04, Vol.3 (4), p.3835-3850

2018

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SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts

ACS medicinal chemistry letters, 2015-02, Vol.6 (2), p.151-155

2015

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Automated techniques in pK a determination: Low, medium and high-throughput screening methods

Drug discovery today. Technologies, 2018-07, Vol.27, p.49

Dardonville, Christophe

2018

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Antiprotozoal Activity of 1-Phenethyl-4-Aminopiperidine Derivatives

Antimicrobial Agents and Chemotherapy, 2009-09, Vol.53 (9), p.3815-3821

2009

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Methyl N-(tert-butoxycarbonyl)pyridine-2-carbimidothioate: A new reagent for the synthesis of N-phenylpyridinecarboxamidine (“arylimidamide”) DNA-minor groove binders from poorly nucleophilic amines

Bioorganic & medicinal chemistry letters, 2022-10, Vol.74, p.128926-128926, Article 128926

2022

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Imidazoline binding sites and their ligands: An overview of the different chemical structures

Medicinal research reviews, 2004-09, Vol.24 (5), p.639-661

2004

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Observation of diastereotopic signals in (15) N NMR spectroscopy

Angewandte Chemie International Edition, 2015-03, Vol.54 (13), p.3997-4000

2015

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Observation of Diastereotopic Signals in 15NNMR Spectroscopy

Angewandte Chemie International Edition, 2015-03, Vol.54 (13), p.3997

International ed. in English, 2015

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Observation of Diastereotopic Signals in 15 N NMR Spectroscopy

Angewandte Chemie International Edition, 2015-03, Vol.54 (13), p.3997-4000

2015

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Observation of Diastereotopic Signals in super(15)NNMR Spectroscopy

Angewandte Chemie International Edition, 2015-03, Vol.54 (13), p.3997-4000

2015

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6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes

Current medicinal chemistry, 2004-10, Vol.11 (19), p.2639-2650

2004

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The structure of fosfomycin salts in solution and in the solid state by nuclear magnetic resonance spectroscopy and DFT calculations

Tetrahedron, 2018-07, Vol.74 (29), p.3937-3942

2018

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Observation of Diastereotopic Signals in 15N NMR Spectroscopy

Angewandte Chemie International Edition, 2015-03, Vol.54 (13), p.3997-4000

2015

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High yield synthesis of trans-azoxybenzene versus 2-isopropoxy-4-nitrobenzoic acid: influence of temperature and base concentration

ARKIVOC free online journal of organic chemistry, 2021-01, Vol.2021 (8), p.265-276

2021

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Alternative oxidase inhibitors: Mitochondrion‐targeting as a strategy for new drugs against pathogenic parasites and fungi

New Benzophenone-Derived Bisphosphonium Salts as Leishmanicidal Leads Targeting Mitochondria through Inhibition of Respiratory Complex II

Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion

Antiprotozoal Activity and DNA Binding of Dicationic Acridones

Bis(2-aminoimidazolines) and Bisguanidines: Synthetic Approaches, Antiparasitic Activity and DNA Binding Properties

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

Automated techniques in pKa determination: Low, medium and high-throughput screening methods

Trypanocidal action of bisphosphonium salts through a mitochondrial target in bloodstream form Trypanosoma brucei

Discovery of nitroheterocycles active against African trypanosomes. In vitro screening and preliminary SAR studies

SAR of 4‑Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase

Aqueous pKa prediction for tautomerizable compounds using equilibrium bond lengths

Prediction of Aqueous pKa Values for Guanidine-Containing Compounds Using Ab Initio Gas-Phase Equilibrium Bond Lengths

SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts

Automated techniques in pK a determination: Low, medium and high-throughput screening methods

Antiprotozoal Activity of 1-Phenethyl-4-Aminopiperidine Derivatives

Methyl N-(tert-butoxycarbonyl)pyridine-2-carbimidothioate: A new reagent for the synthesis of N-phenylpyridinecarboxamidine (“arylimidamide”) DNA-minor groove binders from poorly nucleophilic amines

Imidazoline binding sites and their ligands: An overview of the different chemical structures

Observation of diastereotopic signals in (15) N NMR spectroscopy

Observation of Diastereotopic Signals in 15NNMR Spectroscopy

Observation of Diastereotopic Signals in 15 N NMR Spectroscopy

Observation of Diastereotopic Signals in super(15)NNMR Spectroscopy

6-phosphogluconate dehydrogenase: a target for drugs in African trypanosomes

The structure of fosfomycin salts in solution and in the solid state by nuclear magnetic resonance spectroscopy and DFT calculations

Observation of Diastereotopic Signals in 15N NMR Spectroscopy

High yield synthesis of trans-azoxybenzene versus 2-isopropoxy-4-nitrobenzoic acid: influence of temperature and base concentration

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