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High throughput wide field second harmonic imaging of giant unilamellar vesicles

Biointerphases, 2023-05, Vol.18 (3)

2023

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Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity

Current drug metabolism, 2005-10, Vol.6 (5), p.413-451

2005

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Ticlopidine as a Selective Mechanism-Based Inhibitor of Human Cytochrome P450 2C19

Biochemistry (Easton), 2001-10, Vol.40 (40), p.12112-12122

2001

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The end product of transglutaminase crosslinking: simultaneous quantitation of [Nepsilon-(gamma-glutamyl) lysine] and lysine by HPLC-MS3

Analytical biochemistry, 2009-01, Vol.384 (2), p.296-304

2009

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Indirect Cytotoxicity of Flucloxacillin toward Human Biliary Epithelium via Metabolite Formation in Hepatocytes

Chemical research in toxicology, 2001-06, Vol.14 (6), p.694-701

2001

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Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: Inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

Biochemistry (Easton), 1994-01, Vol.33 (1), p.166-175

1994

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Synthesis of Sulfaphenazole Derivatives and Their Use as Inhibitors and Tools for Comparing the Active Sites of Human Liver Cytochromes P450 of the 2C Subfamily

Journal of medicinal chemistry, 2001-10, Vol.44 (22), p.3622-3631

2001

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Human Anti-Endoplasmic Reticulum Autoantibodies Appearing in a Drug-Induced Hepatitis are Directed against a Human Liver Cytochrome P-450 that Hydroxylates the Drug

Proceedings of the National Academy of Sciences - PNAS, 1987-01, Vol.84 (2), p.551-555

1987

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The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

Biochemistry (Easton), 1995-08, Vol.34 (33), p.10365-10375

1995

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HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins

Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie, 2000-05, Vol.52 (2), p.145-148

2000

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Specificity of in vitro Covalent Binding of Tienilic Acid Metabolites to Human Liver Microsomes in Relationship to the Type of Hepatotoxicity: Comparison with Two Directly Hepatotoxic Drugs

Chemical research in toxicology, 1994-05, Vol.7 (3), p.434-442

1994

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Drug-induced immunotoxicity

European journal of drug metabolism and pharmacokinetics, 1998-10, Vol.23 (4), p.443-451

1998

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Interaction of New Sulfaphenazole Derivatives with Human Liver Cytochrome P450 2Cs: Structural Determinants Required for Selective Recognition by CYP 2C9 and for Inhibition of Human CYP 2Cs

Archives of biochemistry and biophysics, 2001-10, Vol.394 (2), p.189-200

2001

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Thiophene Sulfoxides as Reactive Metabolites: Formation upon Microsomal Oxidation of a 3-Aroylthiophene and Fate in the Presence of Nucleophiles in Vitro and in Vivo

Chemical research in toxicology, 1996-12, Vol.9 (8), p.1403-1413

1996

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Opposite Behaviors of Reactive Metabolites of Tienilic Acid and Its Isomer toward Liver Proteins: Use of Specific Anti-Tienilic Acid−Protein Adduct Antibodies and the Possible Relationship with Different Hepatotoxic Effects of the Two Compounds

Chemical research in toxicology, 1999-03, Vol.12 (3), p.286-296

1999

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Evidence for thiophene-s-oxide as a primary reactive metabolite of thiophene in vivo: Formation of a dihydrothiophene sulfoxide mercapturic acid

Biochemical and biophysical research communications, 1992-08, Vol.186 (3), p.1624-1630

1992

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The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR Study

Biochemistry (Easton), 1997-10, Vol.36 (42), p.12672-12682

1997

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Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes: Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation

Biochemical pharmacology, 1991-02, Vol.41 (4), p.553-560

1991

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Association of cytochromes P450 1A2 and 2B4: are the interactions between different P450 species involved in the control of the monooxygenase activity and coupling?

Advances in experimental medicine and biology, 2001, Vol.500, p.335

2001

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First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives

Biochemical and biophysical research communications, 2005-12, Vol.338 (1), p.450-455

2005

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Hydroxylation of the thiophene ring by hepatic monooxygenases: Evidence for 5-hydroxylation of 2-aroylthiophenes as a general metabolic pathway using a simple UV-visible assay

Biochemical pharmacology, 1990-03, Vol.39 (6), p.1101-1107

1990

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Human Anti-Mitochondria Autoantibodies Appearing in Iproniazid-Induced Immunoallergic Hepatitis Recognize Human Liver Monoamine Oxidase B

Biochemical and biophysical research communications, 1996-01, Vol.218 (1), p.118-124

1996

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Oxidative activation of the thiophene ring by hepatic enzymes: Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes

Biochemical pharmacology, 1990-03, Vol.39 (5), p.911-918

1990

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Detection of human hepatitis anti-liver kidney microsomes (LKM2) autoantibodies on rat liver sections is predominantly due to reactivity with rat liver P-450 IIC11

The Journal of pharmacology and experimental therapeutics, 1991-12, Vol.259 (3), p.1328

1991

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Anti-cytochrome P450 autoantibodies in drug-induced disease

European journal of haematology, 1996-12, Vol.57 (S60), p.89-92

1996

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High throughput wide field second harmonic imaging of giant unilamellar vesicles

Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity

Ticlopidine as a Selective Mechanism-Based Inhibitor of Human Cytochrome P450 2C19

The end product of transglutaminase crosslinking: simultaneous quantitation of [Nepsilon-(gamma-glutamyl) lysine] and lysine by HPLC-MS3

Indirect Cytotoxicity of Flucloxacillin toward Human Biliary Epithelium via Metabolite Formation in Hepatocytes

Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: Inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid

Synthesis of Sulfaphenazole Derivatives and Their Use as Inhibitors and Tools for Comparing the Active Sites of Human Liver Cytochromes P450 of the 2C Subfamily

Human Anti-Endoplasmic Reticulum Autoantibodies Appearing in a Drug-Induced Hepatitis are Directed against a Human Liver Cytochrome P-450 that Hydroxylates the Drug

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An Approach Using Designed Tienilic Acid Derivatives and Molecular Modeling

HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins

Specificity of in vitro Covalent Binding of Tienilic Acid Metabolites to Human Liver Microsomes in Relationship to the Type of Hepatotoxicity: Comparison with Two Directly Hepatotoxic Drugs

Drug-induced immunotoxicity

Interaction of New Sulfaphenazole Derivatives with Human Liver Cytochrome P450 2Cs: Structural Determinants Required for Selective Recognition by CYP 2C9 and for Inhibition of Human CYP 2Cs

Thiophene Sulfoxides as Reactive Metabolites: Formation upon Microsomal Oxidation of a 3-Aroylthiophene and Fate in the Presence of Nucleophiles in Vitro and in Vivo

Opposite Behaviors of Reactive Metabolites of Tienilic Acid and Its Isomer toward Liver Proteins: Use of Specific Anti-Tienilic Acid−Protein Adduct Antibodies and the Possible Relationship with Different Hepatotoxic Effects of the Two Compounds

Evidence for thiophene-s-oxide as a primary reactive metabolite of thiophene in vivo: Formation of a dihydrothiophene sulfoxide mercapturic acid

The Substrate Binding Site of Human Liver Cytochrome P450 2C9: An NMR Study

Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes: Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation

Association of cytochromes P450 1A2 and 2B4: are the interactions between different P450 species involved in the control of the monooxygenase activity and coupling?

First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives

Hydroxylation of the thiophene ring by hepatic monooxygenases: Evidence for 5-hydroxylation of 2-aroylthiophenes as a general metabolic pathway using a simple UV-visible assay

Human Anti-Mitochondria Autoantibodies Appearing in Iproniazid-Induced Immunoallergic Hepatitis Recognize Human Liver Monoamine Oxidase B

Oxidative activation of the thiophene ring by hepatic enzymes: Hydroxylation and formation of electrophilic metabolites during metabolism of tienilic acid and its isomer by rat liver microsomes

Detection of human hepatitis anti-liver kidney microsomes (LKM2) autoantibodies on rat liver sections is predominantly due to reactivity with rat liver P-450 IIC11

Anti-cytochrome P450 autoantibodies in drug-induced disease

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