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Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition

Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (38), p.15180-15188

2013

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Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly

Journal of Virology, 2010-02, Vol.84 (3), p.1607-1615

2010

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MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA in Bacillus subtilis

Proceedings of the National Academy of Sciences - PNAS, 2017-12, Vol.114 (51), p.13537-13542

2017

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Spore-Associated Proteins Involved in c-di-GMP Synthesis and Degradation of Bacillus anthracis

Journal of bacteriology, 2021-08, Vol.203 (17), p.e0013521-e0013521

2021

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Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

Journal of medicinal chemistry, 2023-08, Vol.66 (16), p.11294-11323

2023

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Functional Characterization of Core Components of the Bacillus subtilis Cyclic-Di-GMP Signaling Pathway

Journal of Bacteriology, 2013-11, Vol.195 (21), p.4782-4792

2013

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Structure and Mechanism of a Metal-Sensing Regulatory RNA

Cell, 2007-09, Vol.130 (5), p.878-892

2007

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Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Bioorganic & medicinal chemistry, 2021-05, Vol.37, p.116093-116093, Article 116093

2021

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Nicastrin Functions as a γ-Secretase-Substrate Receptor

Cell, 2005-08, Vol.122 (3), p.435-447

2005

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The C-Terminal Region of Bacillus subtilis SwrA Is Required for Activity and Adaptor-Dependent LonA Proteolysis

Journal of bacteriology, 2018-03, Vol.200 (6), p.e00659-17

2018

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Structural Characterization of 5‑Substituted Pyrrolo[3,2‑d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2

Biochemistry (Easton), 2024-02, Vol.63 (4), p.545-562

2024

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Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State

Journal of the American Chemical Society, 2011-12, Vol.133 (49), p.19614-19617

2011

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Cu(I)-mediated Allosteric Switching in a Copper-sensing Operon Repressor (CsoR)

The Journal of biological chemistry, 2014-07, Vol.289 (27), p.19204-19217

2014

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Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes

Journal of molecular biology, 2009-12, Vol.394 (3), p.544-557

2009

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A new structural paradigm in copper resistance in Streptococcus pneumoniae

Nature chemical biology, 2013-03, Vol.9 (3), p.177

2013

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Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase

Biochemistry (Easton), 2016-08, Vol.55 (32), p.4574-4582

2016

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Novel Pyrrolo[3,2- d ]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

Molecular cancer therapeutics, 2019-10, Vol.18 (10), p.1787-1799

2019

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Tumor Targeting with Novel 6‑Substituted Pyrrolo [2,3‑d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

Journal of medicinal chemistry, 2016-09, Vol.59 (17), p.7856-7876

2016

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6‑Substituted Pyrrolo[2,3‑d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

Journal of medicinal chemistry, 2015-09, Vol.58 (17), p.6938-6959

2015

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Engineering of Bacillus subtilis strains to allow rapid characterization of heterologous diguanylate cyclases and phosphodiesterases

Applied and Environmental Microbiology, 2014-10, Vol.80 (19), p.6167-6174

2014

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Allosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) Family

Journal of molecular biology, 2013-04, Vol.425 (7), p.1143-1157

2013

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Correction to Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase

Biochemistry (Easton), 2017-02, Vol.56 (7), p.1025-1025

2017

Volltextzugriff (PDF)

Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway

Proceedings of the National Academy of Sciences - PNAS, 2002-11, Vol.99 (24), p.15351-15356

2002

Volltextzugriff (PDF)

Oxidative lipid modification of nicastrin enhances amyloidogenic γ‐secretase activity in Alzheimer’s disease

Aging cell, 2012-08, Vol.11 (4), p.559-568

2012

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RNA structure: Riboswitch strikes a chord

Nature chemical biology, 2011-10, Vol.7 (10), p.660

Dann, 3rd, Charles E

2011

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Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition

Conformational Changes in the Hepatitis B Virus Core Protein Are Consistent with a Role for Allostery in Virus Assembly

MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA in Bacillus subtilis

Spore-Associated Proteins Involved in c-di-GMP Synthesis and Degradation of Bacillus anthracis

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria

Functional Characterization of Core Components of the Bacillus subtilis Cyclic-Di-GMP Signaling Pathway

Structure and Mechanism of a Metal-Sensing Regulatory RNA

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors

Nicastrin Functions as a γ-Secretase-Substrate Receptor

The C-Terminal Region of Bacillus subtilis SwrA Is Required for Activity and Adaptor-Dependent LonA Proteolysis

Structural Characterization of 5‑Substituted Pyrrolo[3,2‑d]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2

Crystal Structure of the Zinc-Dependent MarR Family Transcriptional Regulator AdcR in the Zn(II)-Bound State

Cu(I)-mediated Allosteric Switching in a Copper-sensing Operon Repressor (CsoR)

Coronavirus N Protein N-Terminal Domain (NTD) Specifically Binds the Transcriptional Regulatory Sequence (TRS) and Melts TRS-cTRS RNA Duplexes

A new structural paradigm in copper resistance in Streptococcus pneumoniae

Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase

Novel Pyrrolo[3,2- d ]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

Tumor Targeting with Novel 6‑Substituted Pyrrolo [2,3‑d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis

6‑Substituted Pyrrolo[2,3‑d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors

Engineering of Bacillus subtilis strains to allow rapid characterization of heterologous diguanylate cyclases and phosphodiesterases

Allosteric Inhibition of a Zinc-Sensing Transcriptional Repressor: Insights into the Arsenic Repressor (ArsR) Family

Correction to Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase

Structure of Factor-Inhibiting Hypoxia-Inducible Factor 1: An Asparaginyl Hydroxylase Involved in the Hypoxic Response Pathway

Oxidative lipid modification of nicastrin enhances amyloidogenic γ‐secretase activity in Alzheimer’s disease

RNA structure: Riboswitch strikes a chord

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