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Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base–copper complexes

Journal of inorganic biochemistry, 2013-01, Vol.118, p.83-93

2013

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Evaluation of digestion methods for analysis of trace metals in mammalian tissues and NIST 1577c

Analytical biochemistry, 2018-02, Vol.543, p.37-42

2018

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Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells

Breast cancer research : BCR, 2005-01, Vol.7 (6), p.R897-R908, Article R897

2005

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Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells

Biochemical pharmacology, 2005-05, Vol.69 (10), p.1421-1432

2005

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Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer

PloS one, 2014-12, Vol.9 (12), p.e114131-e114131

2014

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Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells

Biochemical pharmacology, 2004-03, Vol.67 (6), p.1139-1151

2004

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Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

The Journal of biological chemistry, 2018-04, Vol.293 (16), p.6187-6200

2018

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Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors

European journal of medicinal chemistry, 2015-01, Vol.90, p.315-331

2015

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Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.1978-1998

2012

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Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ

Biochemical journal, 2010-12, Vol.432 (2), p.255-265

2010

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Copper storage diseases: Menkes, Wilsons, and cancer

Frontiers in bioscience, 2004-09, Vol.9 (1-3), p.2652

2004

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Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (2), p.730-733

2011

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Docking studies and model development of tea polyphenol proteasome inhibitors: Applications to rational drug design

Proteins, structure, function, and bioinformatics, 2004-01, Vol.54 (1), p.58-70

2004

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Computational Validation of the Importance of Absolute Stereochemistry in Virtual Screening

Journal of chemical information and modeling, 2008-03, Vol.48 (3), p.639-645

2008

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Copper-binding compounds as proteasome inhibitors and apoptosis inducers in human cancer

Frontiers in bioscience, 2007-01, Vol.12 (1), p.135

2007

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Proteasome inhibitor patents (2010 - present)

Expert opinion on therapeutic patents, 2014-04, Vol.24 (4), p.369-382

2014

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Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein

Biochemical pharmacology, 2003-09, Vol.66 (6), p.965-976

2003

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Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis

Frontiers in bioscience, 2005-09, Vol.10 (1-3), p.2932

2005

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Anti-angiogenic and anti-tumor properties of proteasome inhibitors

Current cancer drug targets, 2005-11, Vol.5 (7), p.529-541

2005

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Green tea and tea polyphenols in cancer prevention

Frontiers in bioscience, 2004-09, Vol.9 (1-3), p.2618

2004

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The ubiquitin-proteasome system and assays to determine responses to inhibitors

Expert opinion on drug discovery, 2010-12, Vol.5 (12), p.1221-1236

2010

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In Silico Chemical Library Screening and Experimental Validation of a Novel 9-Aminoacridine Based Lead-Inhibitor of Human S-Adenosylmethionine Decarboxylase

Journal of chemical information and modeling, 2007-09, Vol.47 (5), p.1897-1905

2007

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Virtual target screening to rapidly identify potential protein targets of natural products in drug discovery

AIMS molecular science, 2014-01, Vol.1 (2), p.81-98

2014

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Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome β5 subunit

International journal of molecular medicine, 2006-10, Vol.18 (4), p.625-632

2006

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Abstract 6: Computationally assisted target screening of STING agonist for immunologic therapy

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.6-6

2019

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Cellular and computational studies of proteasome inhibition and apoptosis induction in human cancer cells by amino acid Schiff base–copper complexes

Evaluation of digestion methods for analysis of trace metals in mammalian tissues and NIST 1577c

Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells

Dietary flavonoids as proteasome inhibitors and apoptosis inducers in human leukemia cells

Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer

Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon

Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors

Discovery and Synthesis of Hydronaphthoquinones as Novel Proteasome Inhibitors

Transforming JAK1 mutations exhibit differential signalling, FERM domain requirements and growth responses to interferon-γ

Copper storage diseases: Menkes, Wilsons, and cancer

Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs

Docking studies and model development of tea polyphenol proteasome inhibitors: Applications to rational drug design

Computational Validation of the Importance of Absolute Stereochemistry in Virtual Screening

Copper-binding compounds as proteasome inhibitors and apoptosis inducers in human cancer

Proteasome inhibitor patents (2010 - present)

Inhibition of the proteasome activity, a novel mechanism associated with the tumor cell apoptosis-inducing ability of genistein

Inhibition of prostate cancer cellular proteasome activity by a pyrrolidine dithiocarbamate-copper complex is associated with suppression of proliferation and induction of apoptosis

Anti-angiogenic and anti-tumor properties of proteasome inhibitors

Green tea and tea polyphenols in cancer prevention

The ubiquitin-proteasome system and assays to determine responses to inhibitors

In Silico Chemical Library Screening and Experimental Validation of a Novel 9-Aminoacridine Based Lead-Inhibitor of Human S-Adenosylmethionine Decarboxylase

Virtual target screening to rapidly identify potential protein targets of natural products in drug discovery

Methylation of green tea polyphenols affects their binding to and inhibitory poses of the proteasome β5 subunit

Abstract 6: Computationally assisted target screening of STING agonist for immunologic therapy

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