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The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future

Organic process research & development, 2019-06, Vol.23 (6), p.1213-1242

2019

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Collaborative Evaluation of Commercially Available Automated Powder Dispensing Platforms for High-Throughput Experimentation in Pharmaceutical Applications

Organic process research & development, 2018-11, Vol.22 (11), p.1500-1508

2018

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Kinetic and Data-Driven Reaction Analysis for Pharmaceutical Process Development

Industrial & engineering chemistry research, 2020-02, Vol.59 (6), p.2409-2421

2020

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Asymmetric Synthesis of the Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib

Organic process research & development, 2006-05, Vol.10 (3), p.472-480

2006

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Improvements to Enable the Large Scale Synthesis of 1‑{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833)

Organic process research & development, 2018-12, Vol.22 (12), p.1835-1845

2018

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Synthesis of the CETP Inhibitor Torcetrapib: The Resolution Route and Origin of Stereoselectivity in the Iminium Ion Cyclization

Organic process research & development, 2006-05, Vol.10 (3), p.464-471

2006

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Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

Organic process research & development, 2022-03, Vol.26 (3), p.683-697

2022

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Process Development for the Synthesis of Monocyclic β‑Lactam Core 17

Organic process research & development, 2018-02, Vol.22 (2), p.212-218

2018

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The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems

Journal of organic chemistry, 2016-05, Vol.81 (9), p.3509-3519

2016

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Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6‑Bromoisoquinoline-1-carbonitrile with (S)‑3-Amino-2-methylpropan-1-ol

Organic process research & development, 2014-12, Vol.18 (12), p.1752-1758

2014

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Multikilogram Synthesis of a Hepatoselective Glucokinase Activator

Organic process research & development, 2012-10, Vol.16 (10), p.1635-1645

2012

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Mesophase Formation in Regioregular Poly(3-alkylthiophene)s Containing Long Chain Alkyl Groups

Macromolecules, 2008-10, Vol.41 (19), p.7115-7121

2008

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Chemoselective Saponification in the Synthesis of Danuglipron Facilitated with Trifluoroethanol

Organic process research & development, 2024-07, Vol.28 (7), p.2702-2707

2024

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Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB1 Antagonist for the Treatment of Obesity

Organic process research & development, 2009-03, Vol.13 (2), p.186-197

2009

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Synthesis of the ketodifluoromethylene dipeptide isostere

Journal of the American Chemical Society, 1990-08, Vol.112 (17), p.6439-6442

1990

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Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.120-125

1996

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Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity

Tetrahedron, 2009-04, Vol.65 (16), p.3292-3304

2009

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Synthesis and crystallographic analysis of two rhizopuspepsin inhibitor complexes

Biochemistry (Easton), 1992-09, Vol.31 (35), p.8125-8141

1992

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Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity: Recent Advances in Synthetic Methodology: Development and Applications

Tetrahedron, 2009, Vol.65 (16)

2009

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Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB 1 Antagonist for the Treatment of Obesity

Organic process research & development, 2009-03, Vol.13 (2), p.186-197

2009

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Direct observation by X‐ray analysis of the tetrahedral “intermediate” of aspartic proteinases

Protein science, 1992-03, Vol.1 (3), p.322-328

1992

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N-carbamoyl analogs of zafirlukast: Potent receptor antagonists of leukotriene D4

Bioorganic & medicinal chemistry letters, 1998-09, Vol.8 (18), p.2451-2456

1998

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N-carbamoyl analogs of zafirlukast: Potent receptor antagonists of leukotriene D 4

Bioorganic & medicinal chemistry letters, 1998-09, Vol.8 (18), p.2451-2456

1998

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Invader removal triggers competitive release in a threatened avian predator

Proceedings of the National Academy of Sciences - PNAS, 2021-08, Vol.118 (31), p.1

2021

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The Evolution of High-Throughput Experimentation in Pharmaceutical Development and Perspectives on the Future

Collaborative Evaluation of Commercially Available Automated Powder Dispensing Platforms for High-Throughput Experimentation in Pharmaceutical Applications

Kinetic and Data-Driven Reaction Analysis for Pharmaceutical Process Development

Asymmetric Synthesis of the Cholesteryl Ester Transfer Protein Inhibitor Torcetrapib

Improvements to Enable the Large Scale Synthesis of 1‑{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833)

Synthesis of the CETP Inhibitor Torcetrapib: The Resolution Route and Origin of Stereoselectivity in the Iminium Ion Cyclization

Large-Scale Cyclopropanation of Butyl Acrylate with Difluorocarbene and Classical Resolution of a Key Fluorinated Building Block

Process Development for the Synthesis of Monocyclic β‑Lactam Core 17

The Synthesis of Methyl-Substituted Spirocyclic Piperidine-Azetidine (2,7-Diazaspiro[3.5]nonane) and Spirocyclic Piperidine-Pyrrolidine (2,8-Diazaspiro[4.5]decane) Ring Systems

Kiloscale Buchwald–Hartwig Amination: Optimized Coupling of Base-Sensitive 6‑Bromoisoquinoline-1-carbonitrile with (S)‑3-Amino-2-methylpropan-1-ol

Multikilogram Synthesis of a Hepatoselective Glucokinase Activator

Mesophase Formation in Regioregular Poly(3-alkylthiophene)s Containing Long Chain Alkyl Groups

Chemoselective Saponification in the Synthesis of Danuglipron Facilitated with Trifluoroethanol

Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB1 Antagonist for the Treatment of Obesity

Synthesis of the ketodifluoromethylene dipeptide isostere

Biarylcarboxylic Acids and -amides: Inhibition of Phosphodiesterase Type IV versus [3H]Rolipram Binding Activity and Their Relationship to Emetic Behavior in the Ferret

Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity

Synthesis and crystallographic analysis of two rhizopuspepsin inhibitor complexes

Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity: Recent Advances in Synthetic Methodology: Development and Applications

Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB 1 Antagonist for the Treatment of Obesity

Direct observation by X‐ray analysis of the tetrahedral “intermediate” of aspartic proteinases

N-carbamoyl analogs of zafirlukast: Potent receptor antagonists of leukotriene D4

N-carbamoyl analogs of zafirlukast: Potent receptor antagonists of leukotriene D 4

Climate vulnerability assessment for Pacific salmon and steelhead in the California Current Large Marine Ecosystem

Invader removal triggers competitive release in a threatened avian predator

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