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Application of Phosphoramidate Pronucleotide Technology to Abacavir Leads to a Significant Enhancement of Antiviral Potency

Journal of medicinal chemistry, 2005-05, Vol.48 (10), p.3504-3515

2005

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Application of Phosphoramidate ProTide Technology Significantly Improves Antiviral Potency of Carbocyclic Adenosine Derivatives

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.7215-7226

2006

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Membrane permeation characteristics of abacavir in human erythrocytes and human T-lymphoblastoid CD4 + CEM cells: comparison with (−)-carbovir

Biochemical pharmacology, 2004-11, Vol.68 (9), p.1797-1805

2004

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Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5 ′-triphosphate metabolite levels

FEBS letters, 2004-08, Vol.573 (1), p.38-44

2004

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1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

Antimicrobial Agents and Chemotherapy, 1997-05, Vol.41 (5), p.1082-1093

1997

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Phosphoramidate Protides of Carbocyclic 2′,3′-Dideoxy-2′,3′-Didehydro-7-Deazaadenosine with Potent Activity Against HIV and HBV

Nucleosides, nucleotides & nucleic acids, 2004-01, Vol.23 (12), p.1929-1937

2004

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Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89

Antimicrobial Agents and Chemotherapy, 1997-05, Vol.41 (5), p.1099-1107

1997

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Phosphoramidate Protides of 2′,3′-Dideoxy-3′-fluoroadenosine and Related Nucleosides with Potent Activity Against HIV and HBV

Nucleosides, nucleotides & nucleic acids, 2003-10, Vol.22 (10), p.1953-1961

2003

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SYNTHESIS OF NOVEL 8-SUBSTITUTED CARBOCYCLIC ANALOGS OF 2′,3′-DIDEOXYADENOSINE WITH ACTIVITY AGAINST HEPATITIS B VIRUS

Nucleosides, nucleotides & nucleic acids, 2002-12, Vol.21 (11-12), p.891-901

2002

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An Efficient, Scalable Synthesis of the HIV Reverse Transcriptase Inhibitor Ziagen® (1592U89)

Nucleosides, nucleotides & nucleic acids, 2000-01, Vol.19 (1-2), p.297-327

2000

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SYNTHESIS OF CARBOCYCLIC ANALOGS OF 2′,3′-DIDEOXYSANGIVAMYCIN, 2′,3′-DIDEOXYTOYOCAMYCIN, AND 2′,3′-DIDEOXYTRICIRIBINE

Nucleosides, nucleotides & nucleic acids, 2001-12, Vol.20 (10-11), p.1823-1830

2001

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Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity

The Journal of biological chemistry, 1992-10, Vol.267 (29), p.21220-21224

1992

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Effects of a small molecule inhibitor of ICAM-1 and E-selectin expression on colonic inflammatory hyperalgesia and colitis

Gastroenterology (New York, N.Y. 1943), 2003-04, Vol.124 (4), p.A47-A47

2003

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Photoaffinity labeling adenosine A1 receptors with an antagonist iodine-125-labeled aryl azide derivative of 8-phenylxanthine

Journal of medicinal chemistry, 1988-04, Vol.31 (4), p.752-756

1988

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Iodine-125-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors

Journal of medicinal chemistry, 1988-04, Vol.31 (4), p.745-751

1988

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SYNTHESIS OF CARBOCYCLIC ANALOGS OF 2′,3′-DIDEOXYSANGIVAMYCIN, 2′,3′-DIDEOXYTOYOCAMYCIN, AND 2′,3′-DIDEOXYTRICIRIBINE

Nucleosides, nucleotides & nucleic acids, 2001-10, Vol.20 (10-11), p.1823-1830

2001

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DNA polymerase activity of hepatitis B virus particles: differential inhibition by l-enantiomers of nucleotide analogs

Antiviral research, 1996-05, Vol.30 (2), p.133-145

1996

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The synthesis of modified D- and L-anhydrohexitol nucleosides

Tetrahedron letters, 1996-11, Vol.37 (45), p.8147-8150

1996

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Studies Designed to Increase the Stability and Antiviral Activity (HCMV) of the Active Benzimidazole Nucleoside, TCRB

Nucleosides & nucleotides, 1999-04, Vol.18 (4-5), p.509-519

1999

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Enantiomeric selectivity of carbovir transport

The Journal of biological chemistry, 1992-10, Vol.267 (28), p.19792-19797

1992

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A novel, orally-active inidbitor of ICAM-1 and eselectin is efficacious in the treatment of colitis in rhesus macaques

Gastroenterology (New York, N.Y. 1943), 2000-04, Vol.118 (4), p.A863-A863

2000

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Varicella-Zoster virus thymidine kinase: Characterization and substrate specificity

Biochemical pharmacology, 1993-12, Vol.46 (12), p.2209-2218

1993

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Chapter 16. Advances in Nucleoside and Nucleotide Antiviral Therapies

Annual Reports in Medicinal Chemistry, 1998, Vol.33, p.163-171

1998

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Disentangling coupling and NOE pathways involving poorly resolved proton signals: HMQC-TOCSY and HMQC-NOESY

Magnetic resonance in chemistry, 1990-09, Vol.28 (9), p.792-796

1990

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Varicella-Zoster virus thymidine kinase

Biochemical pharmacology, 1993-12, Vol.46 (12), p.2209-2218

1993

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Application of Phosphoramidate Pronucleotide Technology to Abacavir Leads to a Significant Enhancement of Antiviral Potency

Application of Phosphoramidate ProTide Technology Significantly Improves Antiviral Potency of Carbocyclic Adenosine Derivatives

Membrane permeation characteristics of abacavir in human erythrocytes and human T-lymphoblastoid CD4 + CEM cells: comparison with (−)-carbovir

Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5 ′-triphosphate metabolite levels

1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

Phosphoramidate Protides of Carbocyclic 2′,3′-Dideoxy-2′,3′-Didehydro-7-Deazaadenosine with Potent Activity Against HIV and HBV

Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89

Phosphoramidate Protides of 2′,3′-Dideoxy-3′-fluoroadenosine and Related Nucleosides with Potent Activity Against HIV and HBV

SYNTHESIS OF NOVEL 8-SUBSTITUTED CARBOCYCLIC ANALOGS OF 2′,3′-DIDEOXYADENOSINE WITH ACTIVITY AGAINST HEPATITIS B VIRUS

An Efficient, Scalable Synthesis of the HIV Reverse Transcriptase Inhibitor Ziagen® (1592U89)

SYNTHESIS OF CARBOCYCLIC ANALOGS OF 2′,3′-DIDEOXYSANGIVAMYCIN, 2′,3′-DIDEOXYTOYOCAMYCIN, AND 2′,3′-DIDEOXYTRICIRIBINE

Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity

Effects of a small molecule inhibitor of ICAM-1 and E-selectin expression on colonic inflammatory hyperalgesia and colitis

Photoaffinity labeling adenosine A1 receptors with an antagonist iodine-125-labeled aryl azide derivative of 8-phenylxanthine

Iodine-125-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors

SYNTHESIS OF CARBOCYCLIC ANALOGS OF 2′,3′-DIDEOXYSANGIVAMYCIN, 2′,3′-DIDEOXYTOYOCAMYCIN, AND 2′,3′-DIDEOXYTRICIRIBINE

DNA polymerase activity of hepatitis B virus particles: differential inhibition by l-enantiomers of nucleotide analogs

The synthesis of modified D- and L-anhydrohexitol nucleosides

Studies Designed to Increase the Stability and Antiviral Activity (HCMV) of the Active Benzimidazole Nucleoside, TCRB

Enantiomeric selectivity of carbovir transport

A novel, orally-active inidbitor of ICAM-1 and eselectin is efficacious in the treatment of colitis in rhesus macaques

Varicella-Zoster virus thymidine kinase: Characterization and substrate specificity

Chapter 16. Advances in Nucleoside and Nucleotide Antiviral Therapies

Disentangling coupling and NOE pathways involving poorly resolved proton signals: HMQC-TOCSY and HMQC-NOESY

Varicella-Zoster virus thymidine kinase

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