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A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.6147-6153

2013

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Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence

Scientific reports, 2017-01, Vol.7 (1), p.40098, Article 40098

2017

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Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

The Journal of biological chemistry, 2006-08, Vol.281 (33), p.23514-23524

2006

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Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs

ACS chemical biology, 2020-04, Vol.15 (4), p.830-836

2020

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Structural characterization of a human Fc fragment engineered for lack of effector functions

Acta crystallographica. Section D, Biological crystallography., 2008-06, Vol.64 (6), p.700-704

2008

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Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody

mAbs, 2015-03, Vol.7 (2), p.428-439

2015

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Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models

PloS one, 2020-06, Vol.15 (6), p.e0234268-e0234268

2020

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Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension

Bioconjugate chemistry, 2019-04, Vol.30 (4), p.1232-1243

2019

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Insights into the molecular basis of a bispecific antibody's target selectivity

mAbs, 2015-05, Vol.7 (3), p.461-469

2015

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Long-acting antibody ligand mimetics for HER4-selective agonism

Scientific reports, 2020-10, Vol.10 (1), p.17257, Article 17257

2020

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Antibody Fragment F(ab′)2 Targeting Caveolae-Associated Protein PV1 for Selective Kidney Targeting and Retention

Molecular pharmaceutics, 2020-02, Vol.17 (2), p.507-516, Article acs.molpharmaceut.9b00939

2020

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Molecular basis for the mechanism of action of an anti-TACE antibody

mAbs, 2016-11, Vol.8 (8), p.1598-1605

2016

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Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells

Single-Cell Sequencing and Methylation, 2020, Vol.1255, p.221-230

2020

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Functional mimetic of the G-protein coupled receptor CXCR4 on a soluble antibody scaffold

mAbs, 2019-05, Vol.11 (4), p.725-734

2019

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Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding

mAbs, 2015-07, Vol.7 (4), p.743-751

2015

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Tag-on-Demand: exploiting amber codon suppression technology for the enrichment of high-expressing membrane protein cell lines

Protein engineering, design and selection, 2018-10, Vol.31 (10), p.389-398

2018

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Modulation of the Effector Functions of a Human IgG1 through Engineering of Its Hinge Region

Journal of Immunology, 2006-07, Vol.177 (2), p.1129-1138

2006

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Molecular basis for the antagonistic activity of an anti-CXCR4 antibody

mAbs, 2016-01, Vol.8 (1), p.163-175

2016

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Structural characterization of a mutated, ADCC-enhanced human Fc fragment

Molecular immunology, 2008-04, Vol.45 (7), p.1872-1882

2008

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Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

The Journal of biological chemistry, 2014-03, Vol.289 (11), p.7812-7824

2014

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In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Communications biology, 2021-09, Vol.4 (1), p.1048-1048, Article 1048

2021

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Structural characterization of a human Fc fragment engineered for extended serum half-life

Molecular immunology, 2009-05, Vol.46 (8), p.1750-1755

2009

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Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis

Communications biology, 2019-03, Vol.2 (1), p.92-92, Article 92

2019

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pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

The Journal of biological chemistry, 2015-02, Vol.290 (7), p.4282-4290

2015

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An “Fc-Silenced” IgG1 Format With Extended Half-Life Designed for Improved Stability

Journal of pharmaceutical sciences, 2017-04, Vol.106 (4), p.1008-1017

2017

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A Novel Investigational Fc-Modified Humanized Monoclonal Antibody, Motavizumab-YTE, Has an Extended Half-Life in Healthy Adults

Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

Engineering Caveolae-Targeted Lipid Nanoparticles To Deliver mRNA to the Lungs

Structural characterization of a human Fc fragment engineered for lack of effector functions

Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody

Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models

Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension

Insights into the molecular basis of a bispecific antibody's target selectivity

Long-acting antibody ligand mimetics for HER4-selective agonism

Antibody Fragment F(ab′)2 Targeting Caveolae-Associated Protein PV1 for Selective Kidney Targeting and Retention

Molecular basis for the mechanism of action of an anti-TACE antibody

Emerging Strategies for Therapeutic Antibody Discovery from Human B Cells

Functional mimetic of the G-protein coupled receptor CXCR4 on a soluble antibody scaffold

Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding

Tag-on-Demand: exploiting amber codon suppression technology for the enrichment of high-expressing membrane protein cell lines

Modulation of the Effector Functions of a Human IgG1 through Engineering of Its Hinge Region

Molecular basis for the antagonistic activity of an anti-CXCR4 antibody

Structural characterization of a mutated, ADCC-enhanced human Fc fragment

Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Structural characterization of a human Fc fragment engineered for extended serum half-life

Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

An “Fc-Silenced” IgG1 Format With Extended Half-Life Designed for Improved Stability

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