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JNK Signaling in Stem Cell Self-Renewal and Differentiation

International journal of molecular sciences, 2020-04, Vol.21 (7), p.2613

2020

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ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin

Proceedings of the National Academy of Sciences - PNAS, 2023-04, Vol.120 (17), p.e2300902120-e2300902120

2023

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Virtual screening using molecular simulations

Proteins, structure, function, and bioinformatics, 2011-06, Vol.79 (6), p.1940-1951

2011

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Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

Nature communications, 2022-02, Vol.13 (1), p.844-844, Article 844

2022

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MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model

Molecular cancer therapeutics, 2015-12, Vol.14 (12), p.2773-2781

2015

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Raf protomers: Drug binding preferences in living cells

Cell chemical biology, 2023-11, Vol.30 (11), p.1329-1331

Dalby, Kevin N

2023

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Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

Cell death & disease, 2024-01, Vol.15 (1), p.80-80, Article 80

2024

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Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer

PloS one, 2012-07, Vol.7 (7), p.e41171-e41171

2012

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Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (3), p.810-815

2019

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Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer

Scientific reports, 2020-05, Vol.10 (1), p.8537-8537, Article 8537

2020

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Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

Nature communications, 2018-02, Vol.9 (1), p.1-9, Article 512

2018

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The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation

PloS one, 2011-12, Vol.6 (12), p.e28723-e28723

2011

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Short Arrestin-3-Derived Peptides Activate JNK3 in Cells

International journal of molecular sciences, 2022-08, Vol.23 (15), p.8679

2022

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JNK3 Enzyme Binding to Arrestin-3 Differentially Affects the Recruitment of Upstream Mitogen-activated Protein (MAP) Kinase Kinases

The Journal of biological chemistry, 2013-10, Vol.288 (40), p.28535-28547

2013

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Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations

Bioorganic chemistry, 2017-12, Vol.75, p.242-259

2017

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Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs

The Journal of biological chemistry, 2008-07, Vol.283 (28), p.19511-19520

2008

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Construction of human activity‐based phosphorylation networks

Molecular systems biology, 2013, Vol.9 (1), p.655-n/a

2013

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Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

Nature communications, 2019-11, Vol.10 (1), p.5232-15, Article 5232

2019

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Differential Sensing of MAP Kinases Using SOX-Peptides

Angewandte Chemie (International ed.), 2014-12, Vol.53 (51), p.14064-14068

International ed. in English, 2014

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Revealing eEF-2 kinase: recent structural insights into function

Trends in biochemical sciences (Amsterdam. Regular ed.), 2024-02, Vol.49 (2), p.169-182

2024

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Peptide mini-scaffold facilitates JNK3 activation in cells

Scientific reports, 2016-02, Vol.6 (1), p.21025-21025, Article 21025

2016

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A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib

Oncotarget, 2017-12, Vol.8 (62), p.104894-104912

2017

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Development of a cost effective and robust AlphaScreen ® platform for HTS application

BioTechniques, 2018-04, Vol.64 (4), p.181-183

2018

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Mechanistic Studies on Covalent Assemblies of Metal-Mediated Hemi-Aminal Ethers

Chemical science (Cambridge), 2015-01, Vol.6 (1), p.158-164

2015

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JNK Signaling in Stem Cell Self-Renewal and Differentiation

ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin

Virtual screening using molecular simulations

Droplet-based screening of phosphate transfer catalysis reveals how epistasis shapes MAP kinase interactions with substrates

MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model

Raf protomers: Drug binding preferences in living cells

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer

Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding

The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation

Short Arrestin-3-Derived Peptides Activate JNK3 in Cells

JNK3 Enzyme Binding to Arrestin-3 Differentially Affects the Recruitment of Upstream Mitogen-activated Protein (MAP) Kinase Kinases

Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations

Substrate Discrimination among Mitogen-activated Protein Kinases through Distinct Docking Sequence Motifs

Construction of human activity‐based phosphorylation networks

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

Differential Sensing of MAP Kinases Using SOX-Peptides

Revealing eEF-2 kinase: recent structural insights into function

Peptide mini-scaffold facilitates JNK3 activation in cells

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib

Development of a cost effective and robust AlphaScreen ® platform for HTS application

Mechanistic Studies on Covalent Assemblies of Metal-Mediated Hemi-Aminal Ethers

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