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C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN

Journal of the American Society of Nephrology, 2014-02, Vol.25 (2), p.225-231

2014

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Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

PloS one, 2016-10, Vol.11 (10), p.e0164646-e0164646

2016

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CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice

American journal of physiology. Renal physiology, 2013-11, Vol.305 (9), p.F1288-F1297

2013

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CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

Blood, 2012-08, Vol.120 (7), p.1449-1457

2012

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Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease

The Journal of pharmacology and experimental therapeutics, 2010-10, Vol.335 (1), p.61

2010

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Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes

Metabolism, clinical and experimental, 2013-11, Vol.62 (11), p.1623-1632

2013

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Characterization of LY2775240, a selective phosphodiesterase‐4 inhibitor, in nonclinical models and in healthy subjects

Clinical and translational science, 2021-05, Vol.14 (3), p.1037-1048

2021

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Cytomegalovirus Encodes a Potent α Chemokine

Proceedings of the National Academy of Sciences - PNAS, 1999-08, Vol.96 (17), p.9839-9844

1999

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Cytomegalovirus-Encoded β Chemokine Promotes Monocyte-Associated Viremia in the Host

Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (19), p.10881-10886

1999

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Cutting Edge: Identification of a Novel Chemokine Receptor That Binds Dendritic Cell- and T Cell-Active Chemokines Including ELC, SLC, and TECK

The Journal of immunology (1950), 2000-03, Vol.164 (6), p.2851-2856

2000

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CXCR3 antagonism impairs the development of donor-reactive, IFN-gamma-producing effectors and prolongs allograft survival

Transplantation, 2009-02, Vol.87 (3), p.360

2009

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1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists

Bioorganic & medicinal chemistry letters, 2013-03, Vol.23 (5), p.1228-1231

2013

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Neuronal Fractalkine Expression in HIV-1 Encephalitis: Roles for Macrophage Recruitment and Neuroprotection in the Central Nervous System

The Journal of immunology (1950), 2000-02, Vol.164 (3), p.1333-1339

2000

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Comprehensive mapping of poxvirus vCCI chemokine-binding protein. Expanded range of ligand interactions and unusual dissociation kinetics

The Journal of biological chemistry, 2002-01, Vol.277 (4), p.2785-2789

2002

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Neuronal expression of fractalkine in the presence and absence of inflammation

FEBS letters, 1998-11, Vol.439 (3), p.203-207

1998

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Optimization of 2-aminothiazole derivatives as CCR4 antagonists

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (10), p.2800-2803

2006

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Recent Advances in the Discovery and Development of CCR1 Antagonists

Annual Reports in Medicinal Chemistry, 2013, Vol.48, p.133-147

2013

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RANTES Activation of Phospholipase D in Jurkat T Cells: Requirement of GTP-Binding Proteins ARF and RhoA

The Journal of immunology (1950), 1998-02, Vol.160 (4), p.1894-1900

1998

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RANTES-Induced T Cell Activation Correlates with CD3 Expression

The Journal of immunology (1950), 1998-01, Vol.160 (1), p.426-433

1998

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SP004INHIBITION OF THE C5A RECEPTOR BY CCX168 MARKEDLY REDUCES THE THROMBOGENIC POTENTIAL OF SERUM FROM PATIENTS WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME

Nephrology, dialysis, transplantation, 2015-05, Vol.30 (suppl_3), p.iii382-iii382

2015

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Abstract CT223: CCX872: Pharmacodynamic study of a potent and selective CCR2 antagonist in human volunteers and plans for phase Ib trial in patients with pancreatic cancer

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.CT223-CT223

2015

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Orally Administered CCR9 Inhibitor CCX507 Effectively Blocks CCR9 in Circulating Human Leukocytes: 1678

The American journal of gastroenterology, 2014-10, Vol.109, p.S497

2014

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Chemokine Receptor CCR3 Function Is Highly Dependent on Local pH and Ionic Strength

The Journal of biological chemistry, 1997-11, Vol.272 (45), p.28206-28209

1997

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CCR6, a CC Chemokine Receptor that Interacts with Macrophage Inflammatory Protein 3α and Is Highly Expressed in Human Dendritic Cells

The Journal of experimental medicine, 1997-09, Vol.186 (6), p.837-844

1997

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C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice

CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease

Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease

Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes

Characterization of LY2775240, a selective phosphodiesterase‐4 inhibitor, in nonclinical models and in healthy subjects

Correction: Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

Cytomegalovirus Encodes a Potent α Chemokine

Cytomegalovirus-Encoded β Chemokine Promotes Monocyte-Associated Viremia in the Host

Cutting Edge: Identification of a Novel Chemokine Receptor That Binds Dendritic Cell- and T Cell-Active Chemokines Including ELC, SLC, and TECK

CXCR3 antagonism impairs the development of donor-reactive, IFN-gamma-producing effectors and prolongs allograft survival

1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists

Neuronal Fractalkine Expression in HIV-1 Encephalitis: Roles for Macrophage Recruitment and Neuroprotection in the Central Nervous System

Comprehensive mapping of poxvirus vCCI chemokine-binding protein. Expanded range of ligand interactions and unusual dissociation kinetics

Neuronal expression of fractalkine in the presence and absence of inflammation

Optimization of 2-aminothiazole derivatives as CCR4 antagonists

Recent Advances in the Discovery and Development of CCR1 Antagonists

RANTES Activation of Phospholipase D in Jurkat T Cells: Requirement of GTP-Binding Proteins ARF and RhoA

RANTES-Induced T Cell Activation Correlates with CD3 Expression

SP004INHIBITION OF THE C5A RECEPTOR BY CCX168 MARKEDLY REDUCES THE THROMBOGENIC POTENTIAL OF SERUM FROM PATIENTS WITH ATYPICAL HEMOLYTIC UREMIC SYNDROME

Abstract CT223: CCX872: Pharmacodynamic study of a potent and selective CCR2 antagonist in human volunteers and plans for phase Ib trial in patients with pancreatic cancer

Orally Administered CCR9 Inhibitor CCX507 Effectively Blocks CCR9 in Circulating Human Leukocytes: 1678

Chemokine Receptor CCR3 Function Is Highly Dependent on Local pH and Ionic Strength

CCR6, a CC Chemokine Receptor that Interacts with Macrophage Inflammatory Protein 3α and Is Highly Expressed in Human Dendritic Cells

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