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Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2173-2184

2012

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Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein–Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases

Journal of medicinal chemistry, 2022-07, Vol.65 (13), p.8828-8842

2022

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Topical ‘dual-soft’ glucocorticoid receptor agonist for dermatology

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (17), p.127402-127402, Article 127402

2020

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Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5684-5687

2011

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Fragment-Based Discovery of 6‑Arylindazole JAK Inhibitors

ACS medicinal chemistry letters, 2016-06, Vol.7 (6), p.641-646

2016

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The design and synthesis of a novel series of indole derived selective ETA antagonists

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.125-128

2002

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Acidic triazoles as soluble guanylate cyclase stimulators

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (21), p.6515-6518

2011

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Optimisation of a pyrazole series of progesterone antagonists; Part 1

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3384-3386

2010

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Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3404-3406

2011

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A novel series of highly selective inhibitors of MMP-3

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6750-6753

2007

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Thromboxane Modulating Agents. 3. 1H-Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3442-3452

1997

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Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist

Drug metabolism and disposition, 2001-11, Vol.29 (11), p.1424

2001

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A mild and selective C-3 reductive alkylation of indoles

Tetrahedron letters, 1993-02, Vol.34 (9), p.1529-1532

1993

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The design and synthesis of a novel series of indole derived selective ET A antagonists

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (2), p.125-128

2002

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Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists

Bioorganic & medicinal chemistry letters, 1998-08, Vol.8 (16), p.2061-2066

1998

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The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist

Medicinal chemistry research, 2004-01, Vol.13 (3-4), p.149-157

2004

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Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists

Bioorganic & medicinal chemistry letters, 1995-12, Vol.5 (24), p.3017-3022

1995

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Thromboxane Modulating Agents. 3. 1 H -Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

Journal of medicinal chemistry, 1997-10, Vol.40 (21), p.3442-3452

1997

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Thromboxane modulating agents. 2. Thromboxane receptor antagonists derived from the thromboxane synthase inhibitor dazmegrel

Bioorganic & medicinal chemistry letters, 1996-07, Vol.6 (14), p.1691-1696

1996

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ChemInform Abstract: A Novel Series of Highly Selective Inhibitors of MMP-3

ChemInform, 2008-04, Vol.39 (15), p.no-no

2008

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ChemInform Abstract: The Design and Synthesis of a Novel Series of Indole Derived Selective ET A Antagonists

ChemInform, 2002-05, Vol.33 (19)

2002

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ChemInform Abstract: The Design and Synthesis of a Novel Series of Indole Derived Selective ETA Antagonists

ChemInform, 2002-05, Vol.33 (19), p.no-no

2002

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Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7693-7704

2011

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Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib

Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Discovery of an Oral, Rule of 5 Compliant, Interleukin 17A Protein–Protein Interaction Modulator for the Potential Treatment of Psoriasis and Other Inflammatory Diseases

Topical ‘dual-soft’ glucocorticoid receptor agonist for dermatology

Discovery of PF-184563, a potent and selective V1a antagonist for the treatment of dysmenorrhoea. The influence of compound flexibility on microsomal stability

Fragment-Based Discovery of 6‑Arylindazole JAK Inhibitors

The design and synthesis of a novel series of indole derived selective ETA antagonists

Acidic triazoles as soluble guanylate cyclase stimulators

Optimisation of a pyrazole series of progesterone antagonists; Part 1

Synthesis and evaluation of heteroarylalanine diacids as potent and selective neutral endopeptidase inhibitors

A novel series of highly selective inhibitors of MMP-3

Thromboxane Modulating Agents. 3. 1H-Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

Absorption, distribution, metabolism, and excretion considerations in selection of orally active indole-containing endothelin antagonist

A mild and selective C-3 reductive alkylation of indoles

The design and synthesis of a novel series of indole derived selective ET A antagonists

Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists

The Design and Synthesis of a Novel, Orally Active, Selective ETA Antagonist

Thromboxane modulating agents. 1. Design of 1-[(arylsulfonyl)amino] alkylindole derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists

Thromboxane Modulating Agents. 3. 1 H -Imidazol-1-ylalkyl- and 3-Pyridinylalkyl-Substituted 3-[2-[(Arylsulfonyl)amino]ethyl]benzenepropanoic Acid Derivatives as Dual Thromboxane Synthase Inhibitor/Thromboxane Receptor Antagonists

Thromboxane modulating agents. 2. Thromboxane receptor antagonists derived from the thromboxane synthase inhibitor dazmegrel

ChemInform Abstract: A Novel Series of Highly Selective Inhibitors of MMP-3

ChemInform Abstract: The Design and Synthesis of a Novel Series of Indole Derived Selective ET A Antagonists

ChemInform Abstract: The Design and Synthesis of a Novel Series of Indole Derived Selective ETA Antagonists

Discovery of Aryloxy Tetramethylcyclobutanes as Novel Androgen Receptor Antagonists

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