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Applications of CYP450 Testing in the Clinical Setting

Molecular diagnosis & therapy, 2013-06, Vol.17 (3), p.165-184

2013

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Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots

Clinical pharmacology and therapeutics, 2014-09, Vol.96 (3), p.349-359

2014

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Simultaneous determination of melatonin and 6-hydroxymelatonin in human overnight urine by LC-MS/MS

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2021-09, Vol.1181, p.122938-122938, Article 122938

2021

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Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety

British journal of pharmacology, 2010-06, Vol.160 (4), p.919-930

2010

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Drug metabolic enzyme genotype-phenotype discrepancy: High phenoconversion rate in patients treated with antidepressants

Biomedicine & pharmacotherapy, 2022-08, Vol.152, p.113202-113202, Article 113202

2022

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Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future

Clinical pharmacology and therapeutics, 2017-05, Vol.101 (5), p.646-656

2017

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Modern approaches for the phenotyping of cytochrome P450 enzymes in children

Expert review of clinical pharmacology, 2020-07, Vol.13 (7), p.671-674

2020

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Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism

The New England journal of medicine, 2004-12, Vol.351 (27), p.2827-2831

2004

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The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone

British journal of pharmacology, 2010-06, Vol.160 (4), p.907-918

2010

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Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach

Clinical pharmacology and therapeutics, 2016-09, Vol.100 (3), p.295-304

2016

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Antiplatelet Therapy: Targeting the TxA2 Pathway

Journal of cardiovascular translational research, 2014-02, Vol.7 (1), p.29-38

2014

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Influence of the paraoxonase‐1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta‐analysis

Journal of thrombosis and haemostasis, 2012-07, Vol.10 (7), p.1242-1251

2012

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Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability

Current drug metabolism, 2010-10, Vol.11 (8), p.667

2010

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Gabaa Subtypes-Selective Modulation: A Novel Mechanism-Based Approach to the Treatment of Neuropathic Pain

Clinical therapeutics, 2017-08, Vol.39 (8), p.e18-e19

2017

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Impact of Functional Allelic Variations on Drug-Drug Interactions Involving CYP2D6

Clinical therapeutics, 2017-08, Vol.39 (8), p.e71-e71

2017

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The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction

The pharmacogenomics journal, 2009-02, Vol.9 (1), p.34-41

2009

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PP175—Evidence of Drug–Drug Interactions Through Uptake and Efflux Transport Systems in Rat Hepatocytes: Implications For Cellular Concentrations Of Competing Drugs

Clinical therapeutics, 2013-08, Vol.35 (8), p.e72-e72

2013

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Evaluation of CYP450 and transporters expression and activity in heparg cell line under different conditions

Clinical therapeutics, 2015-08, Vol.37 (8), p.e98-e98

2015

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Innovative approach to Blood sampling using dried Blood spots. application to Pharmacokinetics and Cytochrome P450 Phenotyping

Clinical therapeutics, 2015-08, Vol.37 (8), p.e101-e101

2015

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Vincristine-Induced Neuropathic Pain In A Cyp3a5 Non-Expresser With Reduced Cyp3a4 Activity

Clinical therapeutics, 2015-08, Vol.37 (8), p.e134-e134

2015

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In-vitro evaluation of DDI with cobicistat and ritonavir using heparg cell line

Clinical therapeutics, 2015-08, Vol.37 (8), p.e98-e98

2015

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The paraoxonase‐1 pathway is not a major bioactivation pathway of clopidogrel in vitro

British journal of pharmacology, 2012-08, Vol.166 (8), p.2362-2370

2012

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Oral Flurbiprofen Metabolic Ratio Assessment Using a Single‐Point Dried Blood Spot

Clinical pharmacology and therapeutics, 2012-03, Vol.91 (3), p.489-496

2012

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The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation

The pharmacogenomics journal, 2014-06, Vol.14 (3), p.263-271

2014

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Impact of (CYP3A Inhibiting) Antiretroviral Treatment on the Pharmacokinetics and Pharmacodynamics of Clopidogrel and Prasugrel

Clinical therapeutics, 2017-08, Vol.39 (8), p.e65-e65

2017

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Applications of CYP450 Testing in the Clinical Setting

Geneva Cocktail for Cytochrome P450 and P-Glycoprotein Activity Assessment Using Dried Blood Spots

Simultaneous determination of melatonin and 6-hydroxymelatonin in human overnight urine by LC-MS/MS

Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety

Drug metabolic enzyme genotype-phenotype discrepancy: High phenoconversion rate in patients treated with antidepressants

Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future

Modern approaches for the phenotyping of cytochrome P450 enzymes in children

Codeine Intoxication Associated with Ultrarapid CYP2D6 Metabolism

The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone

Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach

Antiplatelet Therapy: Targeting the TxA2 Pathway

Influence of the paraoxonase‐1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta‐analysis

Impact of genetic polymorphisms and drug-drug interactions on clopidogrel and prasugrel response variability

Gabaa Subtypes-Selective Modulation: A Novel Mechanism-Based Approach to the Treatment of Neuropathic Pain

Impact of Functional Allelic Variations on Drug-Drug Interactions Involving CYP2D6

The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction

PP175—Evidence of Drug–Drug Interactions Through Uptake and Efflux Transport Systems in Rat Hepatocytes: Implications For Cellular Concentrations Of Competing Drugs

Evaluation of CYP450 and transporters expression and activity in heparg cell line under different conditions

Innovative approach to Blood sampling using dried Blood spots. application to Pharmacokinetics and Cytochrome P450 Phenotyping

Vincristine-Induced Neuropathic Pain In A Cyp3a5 Non-Expresser With Reduced Cyp3a4 Activity

In-vitro evaluation of DDI with cobicistat and ritonavir using heparg cell line

The paraoxonase‐1 pathway is not a major bioactivation pathway of clopidogrel in vitro

Oral Flurbiprofen Metabolic Ratio Assessment Using a Single‐Point Dried Blood Spot

The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation

Impact of (CYP3A Inhibiting) Antiretroviral Treatment on the Pharmacokinetics and Pharmacodynamics of Clopidogrel and Prasugrel

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