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Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase

Journal of hepatology, 2016, Vol.64 (2), p.S404-S404

2016

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P0679 : Derisking the potential for mitochondrial toxicity of nucleoside analogs

Journal of hepatology, 2015-04, Vol.62, p.S576-S577

2015

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1222 IN VITRO RESISTANCE TO ALS-2200, A POTENT NUCLEOTIDE POLYMERASE INHIBITOR FOR THE TREATMENT OF CHRONIC HEPATITIS C

Journal of hepatology, 2013-04, Vol.58, p.S496-S496

2013

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1219 VX-135, A POTENT SINGLE DIASTEREOMER OF ALS-2200, FOR THE TREATMENT OF CHRONIC HEPATITIS C

Journal of hepatology, 2013-04, Vol.58, p.S495-S495

2013

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THU-226 - Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase

Journal of hepatology, 2016, Vol.64 (2), p.S404-S404

2016

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Stereoisomers of deoxynucleoside 5'-triphosphates as substrates for template-dependent and -independent DNA polymerases

The Journal of biological chemistry, 1997-04, Vol.272 (14), p.9556-9560

1997

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Synthesis, Anti-HIV Activity, and Stability Studies of 5′-Phosphorofluoridate Derivatives of AZT

Bioorganic chemistry, 2001-12, Vol.29 (6), p.333-344

2001

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Cell Cycle Modulation of Gene Targeting by a Triple Helix-forming Oligonucleotide

The Journal of biological chemistry, 2003-03, Vol.278 (13), p.11072-11077

2003

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Targeted gene knockout mediated by triple helix forming oligonucleotides

Nature genetics, 1998-10, Vol.20 (2), p.212-214

1998

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Gamma-phosphate-substituted 2'-deoxynucleoside 5'-triphosphates as substrates for DNA polymerases

The Journal of biological chemistry, 1996-10, Vol.271 (40), p.24389-24394

1996

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Formation of phosphonester bonds catalyzed by DNA polymerase

Nucleic acids research, 1992-02, Vol.20 (4), p.783-789

1992

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Targeted gene knockout mediated by triple helix forming oligonucleotides

Nature genetics, 1998-10, Vol.20 (2), p.212-214

1998

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A New Series of Tricyclic Nucleosides as Potent Inhibitors of Hepatitis C Virus RNA Replication: Design, Synthesis and Structure–Activity Relationships

Antiviral research, 2009-05, Vol.82 (2), p.A29-A29

2009

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Modified Nucleoside 5′-Triphosphonates as a New Type of Antiviral Agents

Nucleosides & nucleotides, 1999-04, Vol.18 (4-5), p.1027-1028

1999

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Discovery and In vitro Characterization of a Novel, Chain-terminating Tricyclic Nucleoside, GL60630, with Potent Anti-HCV Activity

Antiviral research, 2009-05, Vol.82 (2), p.A20-A20

2009

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Minor Groove DNA Binders as Antimicrobial Agents. 1. Pyrrole Tetraamides Are Potent Antibacterials against Vancomycin Resistant Enteroccoci and Methicillin Resistant Staphylococcus aureus

Journal of medicinal chemistry, 2002-02, Vol.45 (4), p.805-817

2002

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Synthesis and Biological Activity of 7-Deaza-7-ethynyl-2′-deoxy-2′-fluoro-2′-C-methyladenosine and its 2′-C-Methyl-ribo Analogue

Nucleic Acids Symposium Series, 2008, Vol.52 (1), p.643-644

2008

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Modified substrates of DNA polymerases and design of antivirals

Acta biochimica polonica, 1996-01, Vol.43 (1), p.125-132

1996

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Nucleoside 5′-triphosphates modified at sugar residues as substrates for DNA polymerase from the thermoacidophilic archaebacterium Sulfolobus acidocaldarius

Biochimica et biophysica acta, 1989-06, Vol.1008 (1), p.113-115

1989

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Modified triphosphates of carbocyclic nucleoside analogues: Synthesis, stability towards alkaline phosphatase and substrate properties for some DNA polymerases

Bioorganic & medicinal chemistry letters, 1996-11, Vol.6 (22), p.2639-2642

1996

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Terminating substrates of DNA polymerases: synthesis and functional study

Nucleic acids symposium series (1979), 1987 (18), p.117-120

1987

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Selectivity of DNA polymerases toward α and β nucleotide substrates of d and l series

FEBS letters, 1994-11, Vol.354 (2), p.187-190

1994

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A Simple Multi-Gram Synthesis of 5′-Hydrogenphosphonates and 5′-Phosphorofluoridates of Sugar Modified Nucleosides

Nucleosides & nucleotides, 1993-12, Vol.12 (10), p.1085-1092

1993

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Synthesis, Anti-HIV Activity and Stability Studies of 3′-Azido-2′,3′-dideoxythymidine-5′-fluorophosphate

Nucleosides & nucleotides, 1999-04, Vol.18 (4-5), p.983-984

1999

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Formation and Reactivity of 2,4-Ditriazolyl Pyrimidine C-Nucleoside Derived from Pseudouridine

Nucleosides, nucleotides & nucleic acids, 2000-03, Vol.19 (3), p.585-591

2000

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Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase

P0679 : Derisking the potential for mitochondrial toxicity of nucleoside analogs

1222 IN VITRO RESISTANCE TO ALS-2200, A POTENT NUCLEOTIDE POLYMERASE INHIBITOR FOR THE TREATMENT OF CHRONIC HEPATITIS C

1219 VX-135, A POTENT SINGLE DIASTEREOMER OF ALS-2200, FOR THE TREATMENT OF CHRONIC HEPATITIS C

THU-226 - Pan-Genotypic Evaluation of AL-335, a Clinical Stage Uridine Analogue Inhibitor of Hepatitis C Virus Polymerase

Stereoisomers of deoxynucleoside 5'-triphosphates as substrates for template-dependent and -independent DNA polymerases

Synthesis, Anti-HIV Activity, and Stability Studies of 5′-Phosphorofluoridate Derivatives of AZT

Cell Cycle Modulation of Gene Targeting by a Triple Helix-forming Oligonucleotide

Targeted gene knockout mediated by triple helix forming oligonucleotides

Gamma-phosphate-substituted 2'-deoxynucleoside 5'-triphosphates as substrates for DNA polymerases

Formation of phosphonester bonds catalyzed by DNA polymerase

Targeted gene knockout mediated by triple helix forming oligonucleotides

A New Series of Tricyclic Nucleosides as Potent Inhibitors of Hepatitis C Virus RNA Replication: Design, Synthesis and Structure–Activity Relationships

Modified Nucleoside 5′-Triphosphonates as a New Type of Antiviral Agents

Discovery and In vitro Characterization of a Novel, Chain-terminating Tricyclic Nucleoside, GL60630, with Potent Anti-HCV Activity

Minor Groove DNA Binders as Antimicrobial Agents. 1. Pyrrole Tetraamides Are Potent Antibacterials against Vancomycin Resistant Enteroccoci and Methicillin Resistant Staphylococcus aureus

Synthesis and Biological Activity of 7-Deaza-7-ethynyl-2′-deoxy-2′-fluoro-2′-C-methyladenosine and its 2′-C-Methyl-ribo Analogue

Modified substrates of DNA polymerases and design of antivirals

Nucleoside 5′-triphosphates modified at sugar residues as substrates for DNA polymerase from the thermoacidophilic archaebacterium Sulfolobus acidocaldarius

Modified triphosphates of carbocyclic nucleoside analogues: Synthesis, stability towards alkaline phosphatase and substrate properties for some DNA polymerases

Terminating substrates of DNA polymerases: synthesis and functional study

Selectivity of DNA polymerases toward α and β nucleotide substrates of d and l series

A Simple Multi-Gram Synthesis of 5′-Hydrogenphosphonates and 5′-Phosphorofluoridates of Sugar Modified Nucleosides

Synthesis, Anti-HIV Activity and Stability Studies of 3′-Azido-2′,3′-dideoxythymidine-5′-fluorophosphate

Formation and Reactivity of 2,4-Ditriazolyl Pyrimidine C-Nucleoside Derived from Pseudouridine

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