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Why 90% of clinical drug development fails and how to improve it?

Acta pharmaceutica Sinica. B, 2022-07, Vol.12 (7), p.3049-3062

2022

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Engineering exosomes as refined biological nanoplatforms for drug delivery

Acta pharmacologica Sinica, 2017-06, Vol.38 (6), p.754-763

2017

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Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit

The AAPS journal, 2020-05, Vol.22 (4), p.77, Article 77

Sun, Duxin

2020

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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

Cell metabolism, 2018-07, Vol.28 (1), p.87-103.e6

2018

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Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

Cell metabolism, 2020-01, Vol.31 (1), p.115-130.e6

2020

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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6685-6704

2018

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Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

Journal of medicinal chemistry, 2019-12, Vol.62 (24), p.11280-11300

2019

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Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer

Journal of medicinal chemistry, 2022-02, Vol.65 (4), p.3404-3419

2022

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Tumor-derived exosomes: Nanovesicles made by cancer cells to promote cancer metastasis

Acta pharmaceutica Sinica. B, 2021-08, Vol.11 (8), p.2136-2149

2021

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Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors

Journal of medicinal chemistry, 2022-01, Vol.65 (1), p.343-368

2022

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Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer

Cancer research (Chicago, Ill.), 2017-05, Vol.77 (9), p.2476-2487

2017

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Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

Science translational medicine, 2020-12, Vol.12 (572)

2020

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A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

Journal of medicinal chemistry, 2013-07, Vol.56 (13), p.5553-5561

2013

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ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs

Nature communications, 2023-02, Vol.14 (1), p.993-14, Article 993

2023

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Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

Clinical cancer research, 2010-05, Vol.16 (9), p.2580-2590

2010

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Sulforaphane Enhances the Anticancer Activity of Taxanes against Triple Negative Breast Cancer by Killing Cancer Stem Cells

Cancer letters, 2017-05, Vol.394, p.52-64

2017

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Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Cancer cell, 2015-04, Vol.27 (4), p.589-602

2015

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Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

Nature communications, 2021-05, Vol.12 (1), p.2792-14, Article 2792

2021

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Therapeutic targeting of TP53-mutated acute myeloid leukemia by inhibiting HIF-1α with echinomycin

Oncogene, 2020-04, Vol.39 (14), p.3015-3027

2020

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Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction

The Journal of biological chemistry, 2009-12, Vol.284 (51), p.35381-35389

2009

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A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

Molecular cancer therapeutics, 2014-03, Vol.13 (3), p.565-575

2014

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A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

Molecular cancer therapeutics, 2008-01, Vol.7 (1), p.162-170

2008

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Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds

The Journal of nutritional biochemistry, 2011-09, Vol.22 (9), p.799-806

2011

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Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations

International journal of pharmaceutics, 2017-03, Vol.519 (1-2), p.1-10

2017

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Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

Molecular pharmaceutics, 2017-12, Vol.14 (12), p.4281-4294

2017

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Why 90% of clinical drug development fails and how to improve it?

Engineering exosomes as refined biological nanoplatforms for drug delivery

Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit

Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein

Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer

Tumor-derived exosomes: Nanovesicles made by cancer cells to promote cancer metastasis

Discovery and Lead Optimization of Benzene-1,4-disulfonamides as Oxidative Phosphorylation Inhibitors

Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

A Potent Small-Molecule Inhibitor of the MDM2–p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice

ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

Sulforaphane Enhances the Anticancer Activity of Taxanes against Triple Negative Breast Cancer by Killing Cancer Stem Cells

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

Therapeutic targeting of TP53-mutated acute myeloid leukemia by inhibiting HIF-1α with echinomycin

Characterization of Celastrol to Inhibit Hsp90 and Cdc37 Interaction

A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivo

A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells

Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds

Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations

Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs

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