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Human Thymidylate Synthase Is in the Closed Conformation When Complexed with dUMP and Raltitrexed, an Antifolate Drug

Biochemistry (Easton), 2001-02, Vol.40 (7), p.1897-1902

2001

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Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors

The Journal of biological chemistry, 2001-04, Vol.276 (17), p.14170-14177

2001

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Probing an Acyl Enzyme of Selenosubtilisin by Raman Spectroscopy

Journal of the American Chemical Society, 1996-01, Vol.118 (1), p.239-240

1996

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Studies of 5-fluorodeoxyuridine 5'-monophosphate binding to carboxypeptidase A-inactivated thymidylate synthase from Lactobacillus casei

The Journal of biological chemistry, 1993-05, Vol.268 (14), p.10102-10108

1993

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Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase

Molecular pharmacology, 1995-07, Vol.48 (1), p.72-79

1995

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Correction for light absorption in fluorescence studies of protein-ligand interactions

Analytical biochemistry, 1983-07, Vol.132 (2), p.353-361

1983

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Characterization of a novel form of thymidylate synthase: A heterodimer isolated after specific chemical modification of the immobilized native enzyme

Biochemistry (Easton), 1993-11, Vol.32 (47), p.12774-12781

1993

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Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates

The Journal of biological chemistry, 1986-09, Vol.261 (27), p.12745-12749

1986

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Substitution of glutamine for glutamic acid-58 in Escherichia coli thymidylate synthase results in pronounced decreases in catalytic activity and ligand binding

Biochemistry (Easton), 1993-09, Vol.32 (36), p.9274-9281

1993

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Further biological activities of the novel choline analogs selenonium choline and acetylselenonium choline

The Journal of pharmacology and experimental therapeutics, 1993-08, Vol.266 (2), p.593

1993

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Synthesis of novel tellurium containing analogues of choline and acetylcholine and their quantitation by pyrolysis-gas chromatography-mass spectrometry

Journal of Chromatography A, 1993-12, Vol.657 (2), p.395-404

1993

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Catalytic Cysteine of Thymidylate Synthase Is Activated upon Substrate Binding

Biochemistry (Easton), 2000-06, Vol.39 (23), p.6969-6978

2000

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Thymidylate synthetase from amethopterin- resistant Lactobacillus casei

Biochemistry (Easton), 1971-01, Vol.10 (1), p.88-97

1971

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Trapping and partial characterization of an adduct postulated to be the covalent catalytic ternary complex of thymidylate synthase

Biochemistry (Easton), 1986-06, Vol.25 (11), p.3311-3317

1986

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Efficient synthesis of mouse thymidylate synthase in Escherichia coli

Gene, 1989-12, Vol.84 (2), p.487-491

1989

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Kinetic Studies on Drug-Resistant Variants of Escherichia coli Thymidylate Synthase: Functional Effects of Amino Acid Substitutions at Residue 4

Archives of biochemistry and biophysics, 1999-08, Vol.368 (2), p.257-264

1999

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Synthesis of novel selenium-containing choline and acetylcholine analogues and their quantitation using a pyrolysis—gas chromatography—mass spectrometry assay

Journal of Chromatography A, 1991-10, Vol.585 (1), p.101-109

1991

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A Hydroxyl Group at Residue 216 Is Essential for Catalysis by Human Thymidylate Synthase

Biochemistry (Easton), 1998-05, Vol.37 (20), p.7096-7102

1998

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Site-directed mutagenesis of mouse thymidylate synthase: Alteration of Arg44 to Val44 in a conserved loop guarding the active site has striking effects on catalysis and nucleotide binding

Biochemical and biophysical research communications, 1990-03, Vol.167 (3), p.869-875

1990

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Characterization of the covalent chromatography of thymidylate synthase on thiopropyl-Sepharose 6B

Biochimica et biophysica acta, 1993-05, Vol.1163 (2), p.165-175

1993

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A Structural Role for Glutamine 214 in Human Thymidylate Synthase

Biochemistry (Easton), 1998-05, Vol.37 (20), p.7089-7095

1998

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Substitution at Residue 214 of Human Thymidylate Synthase Alters Nucleotide Binding and Isomerization of Ligand−Protein Complexes

Biochemistry (Easton), 1999-04, Vol.38 (17), p.5582-5587

1999

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Characterization of the parameters affecting covalent binding stoichiometry in binary and ternary complexes of thymidylate synthase

Biochimica et biophysica acta, 1990-06, Vol.1039 (2), p.149-156

1990

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Demonstration of the feasibility of observing nuclear magnetic resonance signals of 77Se covalently attached to proteins

The Journal of biological chemistry, 1982-02, Vol.257 (3), p.1142-1144

1982

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Interaction of dihydrofolate reductase from amethopterin-resistant Lactobacillus casei with Cibacron Blue, Blue Dextran, and Affi-Gel Blue

The Journal of biological chemistry, 1979-07, Vol.254 (14), p.6515-6521

1979

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Human Thymidylate Synthase Is in the Closed Conformation When Complexed with dUMP and Raltitrexed, an Antifolate Drug

Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors

Probing an Acyl Enzyme of Selenosubtilisin by Raman Spectroscopy

Studies of 5-fluorodeoxyuridine 5'-monophosphate binding to carboxypeptidase A-inactivated thymidylate synthase from Lactobacillus casei

Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase

Correction for light absorption in fluorescence studies of protein-ligand interactions

Characterization of a novel form of thymidylate synthase: A heterodimer isolated after specific chemical modification of the immobilized native enzyme

Evidence for the existence of covalent nucleotide-thymidylate synthase complexes, identification of site of attachment, and enhancement by folates

Substitution of glutamine for glutamic acid-58 in Escherichia coli thymidylate synthase results in pronounced decreases in catalytic activity and ligand binding

Further biological activities of the novel choline analogs selenonium choline and acetylselenonium choline

Synthesis of novel tellurium containing analogues of choline and acetylcholine and their quantitation by pyrolysis-gas chromatography-mass spectrometry

Catalytic Cysteine of Thymidylate Synthase Is Activated upon Substrate Binding

Thymidylate synthetase from amethopterin- resistant Lactobacillus casei

Trapping and partial characterization of an adduct postulated to be the covalent catalytic ternary complex of thymidylate synthase

Efficient synthesis of mouse thymidylate synthase in Escherichia coli

Kinetic Studies on Drug-Resistant Variants of Escherichia coli Thymidylate Synthase: Functional Effects of Amino Acid Substitutions at Residue 4

Synthesis of novel selenium-containing choline and acetylcholine analogues and their quantitation using a pyrolysis—gas chromatography—mass spectrometry assay

A Hydroxyl Group at Residue 216 Is Essential for Catalysis by Human Thymidylate Synthase

Site-directed mutagenesis of mouse thymidylate synthase: Alteration of Arg44 to Val44 in a conserved loop guarding the active site has striking effects on catalysis and nucleotide binding

Characterization of the covalent chromatography of thymidylate synthase on thiopropyl-Sepharose 6B

A Structural Role for Glutamine 214 in Human Thymidylate Synthase

Substitution at Residue 214 of Human Thymidylate Synthase Alters Nucleotide Binding and Isomerization of Ligand−Protein Complexes

Characterization of the parameters affecting covalent binding stoichiometry in binary and ternary complexes of thymidylate synthase

Demonstration of the feasibility of observing nuclear magnetic resonance signals of 77Se covalently attached to proteins

Interaction of dihydrofolate reductase from amethopterin-resistant Lactobacillus casei with Cibacron Blue, Blue Dextran, and Affi-Gel Blue

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