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Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies

The EMBO journal, 2023-05, Vol.42 (10), p.e111699-n/a

2023

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A Concise and Efficient Synthesis of Substituted Morpholines

Synthesis (Stuttgart), 2014-12, Vol.47 (5), p.712-720

2014

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Progressive transforming growth factor β1-induced lung fibrosis is blocked by an orally active alk5 kinase inhibitor

American journal of respiratory and critical care medicine, 2005-04, Vol.171 (8), p.889-898

2005

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SPR965, a Dual PI3K/mTOR Inhibitor, as a Targeted Therapy in Ovarian Cancer

Frontiers in oncology, 2021-02, Vol.10, p.624498-624498

2021

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Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo

Clinical cancer research, 2006-07, Vol.12 (14), p.4315-4330

2006

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Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins

Anti-cancer agents in medicinal chemistry, 2017, Vol.17 (1), p.40-47

2017

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Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers

Food & function, 2015-03, Vol.6 (3), p.824-833

2015

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Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness

European journal of pharmacology, 2006-08, Vol.544 (1), p.160-167

2006

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Outsourcing drug discovery to India and China: from surviving to thriving

Drug discovery today, 2012-10, Vol.17 (19-20), p.1055-1058

2012

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Abstract 15690: Bioactive Fumarate Improves Cardiac Function and Expands Lifespan in Friedreich's Ataxia

Circulation (New York, N.Y.), 2022-11, Vol.146 (Suppl_1)

2022

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Discovery and Development of SPR519 as a Potent, Selective, and Orally Bioavailable Inhibitor of PI3Kα and mTOR Kinases for the Treatment of Solid Tumors

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.11121-11130

2020

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(−)‐Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy

Muscle & nerve, 2021-02, Vol.63 (2), p.239-249

2021

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Bioactive fumarate improves cardiac function and expands lifespan in Friedrech's ataxia

Biophysical journal, 2023-02, Vol.122 (3), p.96a-96a

2023

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A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects

International journal of cardiology, 2016-11, Vol.223, p.500-506

2016

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Synthesis and evaluation of pyrrolotriazine based molecules as PI3 kinase inhibitors

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (16), p.3142-3146

2015

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Abstract LB196: SPR965, a PI3K/mTORC1/C2 inhibitor for treatment of chordoma

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.LB196-LB196

2022

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Clinical Pharmacokinetics and Preclinical Pharmacodynamics of (+)‐Epicatechin on Cardiometabolic Endpoints

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Stimulatory Effects of the Flavanols (−)‐Epicatechin and its Enantiomer (+)‐Epicatechin on Frontal Cortex Markers of Neurogenesis

The FASEB journal, 2018-04, Vol.32 (S1), p.823.4-823.4

2018

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Stimulatory effects of (−)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept

Food & function, 2021-04, Vol.12 (8), p.354-3515

2021

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p38α-Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation

The Journal of pharmacology and experimental therapeutics, 2008-03, Vol.324 (3), p.921-929

2008

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Safety and efficacy of (+)‐epicatechin in subjects with Friedreich's ataxia: A phase II, open‐label, prospective study

Journal of inherited metabolic disease, 2021-03, Vol.44 (2), p.502-514

2021

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ATPS-61NEW SMALL MOLECULES THAT KILL HYPOXICALLY TRANSFORMED GLIOMA STEM-LIKE CELLS

Neuro-oncology (Charlottesville, Va.), 2015-11, Vol.17 (suppl 5), p.v31.4-v31

2015

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Discovery of Novel and Orally Bioavailable Inhibitors of PI3 Kinase Based on Indazole Substituted Morpholino-Triazines

ACS medicinal chemistry letters, 2015-12, Vol.6 (12), p.1190-1194

2015

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Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype

Cancer research (Chicago, Ill.), 2004-08, Vol.64 (15), p.5200-5211

2004

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Abstract 2653: Preclinical activity of dual PI3K/mTOR inhibitor SPR965 in multiple myeloma

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2653-2653

2015

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Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies

A Concise and Efficient Synthesis of Substituted Morpholines

Progressive transforming growth factor β1-induced lung fibrosis is blocked by an orally active alk5 kinase inhibitor

SPR965, a Dual PI3K/mTOR Inhibitor, as a Targeted Therapy in Ovarian Cancer

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor Kinase In vivo

Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins

Pharmacokinetic, partial pharmacodynamic and initial safety analysis of (-)-epicatechin in healthy volunteers

Importance of p38 mitogen-activated protein kinase pathway in allergic airway remodelling and bronchial hyperresponsiveness

Outsourcing drug discovery to India and China: from surviving to thriving

Abstract 15690: Bioactive Fumarate Improves Cardiac Function and Expands Lifespan in Friedreich's Ataxia

Discovery and Development of SPR519 as a Potent, Selective, and Orally Bioavailable Inhibitor of PI3Kα and mTOR Kinases for the Treatment of Solid Tumors

(−)‐Epicatechin induces mitochondrial biogenesis and markers of muscle regeneration in adults with Becker muscular dystrophy

Bioactive fumarate improves cardiac function and expands lifespan in Friedrech's ataxia

A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects

Synthesis and evaluation of pyrrolotriazine based molecules as PI3 kinase inhibitors

Abstract LB196: SPR965, a PI3K/mTORC1/C2 inhibitor for treatment of chordoma

Clinical Pharmacokinetics and Preclinical Pharmacodynamics of (+)‐Epicatechin on Cardiometabolic Endpoints

Stimulatory Effects of the Flavanols (−)‐Epicatechin and its Enantiomer (+)‐Epicatechin on Frontal Cortex Markers of Neurogenesis

Stimulatory effects of (−)-epicatechin and its enantiomer (+)-epicatechin on mouse frontal cortex neurogenesis markers and short-term memory: proof of concept

p38α-Selective Mitogen-Activated Protein Kinase Inhibitor SD-282 Reduces Inflammation in a Subchronic Model of Tobacco Smoke-Induced Airway Inflammation

Safety and efficacy of (+)‐epicatechin in subjects with Friedreich's ataxia: A phase II, open‐label, prospective study

ATPS-61NEW SMALL MOLECULES THAT KILL HYPOXICALLY TRANSFORMED GLIOMA STEM-LIKE CELLS

Discovery of Novel and Orally Bioavailable Inhibitors of PI3 Kinase Based on Indazole Substituted Morpholino-Triazines

Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype

Abstract 2653: Preclinical activity of dual PI3K/mTOR inhibitor SPR965 in multiple myeloma

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