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SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

Nature chemical biology, 2021-02, Vol.17 (2), p.222-228

2021

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Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity

Nature protocols, 2017-10, Vol.12 (10), p.2189-2214

2017

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Caspase substrates and inhibitors

Cold Spring Harbor perspectives in biology, 2013-08, Vol.5 (8), p.a008680-a008680

2013

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Imaging of proteases using activity-based probes

Current opinion in chemical biology, 2023-06, Vol.74, p.102299-102299, Article 102299

2023

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Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples

Journal of medicinal chemistry, 2018-06, Vol.61 (12), p.5222-5234

2018

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SUMO-mediated regulation of NLRP3 modulates inflammasome activity

Nature communications, 2018-08, Vol.9 (1), p.3001-14, Article 3001

2018

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Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease

Antiviral research, 2017-03, Vol.139, p.88-94

2017

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Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

Cell death and differentiation, 2019-12, Vol.26 (12), p.2695-2709

2019

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Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design

Science advances, 2020-10, Vol.6 (42)

2020

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Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)

Cancer cell international, 2017-01, Vol.17 (1), p.4-4, Article 4

2017

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Investigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagents

Cell chemical biology, 2023-02, Vol.30 (2), p.159-174.e8

2023

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Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells

Cell death and differentiation, 2020-02, Vol.27 (2), p.451-465

2020

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Diagnostic and therapeutic potential of protease inhibition

Molecular aspects of medicine, 2022-12, Vol.88, p.101144-101144, Article 101144

2022

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The Strategies to Support the COVID-19 Vaccination with Evidence-Based Communication and Tackling Misinformation

Vaccines (Basel), 2021-02, Vol.9 (2), p.109

2021

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Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma

Journal of medicinal chemistry, 2023-03, Vol.66 (6), p.3785-3797

2023

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Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (7), p.2518-2523

2014

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Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin

Organic letters, 2022-08, Vol.24 (30), p.5602-5607

2022

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Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease

ACS chemical biology, 2019-11, Vol.14 (11), p.2453-2462

2019

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Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

Chemical science (Cambridge), 2018, Vol.9 (8), p.2113-2129

2018

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A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Cell reports (Cambridge), 2021-09, Vol.36 (13), p.109754-109754, Article 109754

2021

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Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe

Journal of medicinal chemistry, 2020-03, Vol.63 (6), p.3359-3369

2020

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Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development

Frontiers in chemistry, 2022-02, Vol.9, p.819165-819165

2022

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Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes

The Journal of biological chemistry, 2020-07, Vol.295 (28), p.9567-9582

2020

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Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

Scientific reports, 2022-08, Vol.12 (1), p.14230-14230, Article 14230

2022

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Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

PloS one, 2015-07, Vol.10 (7), p.e0132818-e0132818

2015

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SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging

Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity

Caspase substrates and inhibitors

Imaging of proteases using activity-based probes

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples

SUMO-mediated regulation of NLRP3 modulates inflammasome activity

Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 protease

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design

Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)

Investigation of osteoclast cathepsin K activity in osteoclastogenesis and bone loss using a set of chemical reagents

Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells

Diagnostic and therapeutic potential of protease inhibition

The Strategies to Support the COVID-19 Vaccination with Evidence-Based Communication and Tackling Misinformation

Fluorescent Activity-Based Probe To Image and Inhibit Factor XIa Activity in Human Plasma

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling

Green-Emitting 4,5-Diaminonaphthalimides in Activity-Based Probes for the Detection of Thrombin

Leveraging Peptide Substrate Libraries to Design Inhibitors of Bacterial Lon Protease

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease

Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe

Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes

Evaluation of the anti-SARS-CoV-2 properties of essential oils and aromatic extracts

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4

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