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PTEN function: how normal cells control it and tumour cells lose it

Biochemical journal, 2004-08, Vol.382 (Pt 1), p.1-11

2004

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The TSC1-2 Tumor Suppressor Controls Insulin-PI3K Signaling via Regulation of IRS Proteins

The Journal of cell biology, 2004-07, Vol.166 (2), p.213-223

2004

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Probing phosphoinositide functions in signaling and membrane trafficking

Trends in cell biology, 2005-05, Vol.15 (5), p.259-268

2005

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Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress

The Journal of biological chemistry, 2010-04, Vol.285 (17), p.12620-12628

2010

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Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

The EMBO journal, 2004-10, Vol.23 (20), p.3918-3928

2004

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dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

Nature cell biology, 2002-03, Vol.4 (3), p.251-255

2002

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Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

Analytical biochemistry, 2003-02, Vol.313 (2), p.234-245

2003

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The Role of Dynamin and Its Binding Partners in Coated Pit Invagination and Scission

The Journal of cell biology, 2001-01, Vol.152 (2), p.309-323

2001

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Redox regulation of PI 3-kinase signalling via inactivation of PTEN

The EMBO journal, 2003-10, Vol.22 (20), p.5501-5510

2003

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Regulation of Insulin Receptor Substrate 1 Pleckstrin Homology Domain by Protein Kinase C: Role of Serine 24 Phosphorylation

Molecular endocrinology (Baltimore, Md.), 2006-08, Vol.20 (8), p.1838-1852

2006

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The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

Biochemical journal, 2007-10, Vol.407 (2), p.255-266

2007

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Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates

The Journal of biological chemistry, 2009-04, Vol.284 (16), p.10571-10582

2009

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Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

Biochemical journal, 1996-05, Vol.315 ( Pt 3) (3), p.709-713

1996

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PTEN: The down side of PI 3-kinase signalling

Cellular Signalling, 2002-04, Vol.14 (4), p.285-295

2002

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Localization of agonist-sensitive PtdIns(3,4,5)P₃ reveals a nuclear pool that is insensitive to PTEN expression

Journal of cell science, 2006-12, Vol.119 (24), p.5160-5168

2006

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Interleukin-3-mediated Cell Survival Signals Include Phosphatidylinositol 3-Kinase-dependent Translocation of the Glucose Transporter GLUT1 to the Cell Surface

The Journal of biological chemistry, 2003-10, Vol.278 (41), p.39337-39348

2003

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A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

The Journal of experimental medicine, 2002-09, Vol.196 (6), p.753-763

2002

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MyosinV controls PTEN function and neuronal cell size

Nature cell biology, 2009-10, Vol.11 (10), p.1191-1196

2009

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Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy

Biochemical journal, 2004-02, Vol.377 (Pt 3), p.653-663

2004

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Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C δ1

Biochemical journal, 2002-05, Vol.363 (3), p.657

2002

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Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Biochemical journal, 2004-09, Vol.382 (Pt 3), p.857-865

2004

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Muscarinic Receptors Mediate Phospholipase C-dependent Activation of Protein Kinase B via Ca2+, ErbB3, and Phosphoinositide 3-Kinase in 1321N1 Astrocytoma Cells

The Journal of biological chemistry, 2002-01, Vol.277 (1), p.338-344

2002

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Differential redox regulation within the PTP superfamily

Cellular signalling, 2007-07, Vol.19 (7), p.1521-1530

2007

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The Lipid Phosphatase Activity of PTEN is Critical for Its Tumor Supressor Function

Proceedings of the National Academy of Sciences - PNAS, 1998-11, Vol.95 (23), p.13513-13518

1998

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The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif

Biochemical journal, 2004-04, Vol.379 (Pt 2), p.301-307

2004

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PTEN function: how normal cells control it and tumour cells lose it

The TSC1-2 Tumor Suppressor Controls Insulin-PI3K Signaling via Regulation of IRS Proteins

Probing phosphoinositide functions in signaling and membrane trafficking

Ubiquitination of PTEN (Phosphatase and Tensin Homolog) Inhibits Phosphatase Activity and Is Enhanced by Membrane Targeting and Hyperosmotic Stress

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

The Role of Dynamin and Its Binding Partners in Coated Pit Invagination and Scission

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

Regulation of Insulin Receptor Substrate 1 Pleckstrin Homology Domain by Protein Kinase C: Role of Serine 24 Phosphorylation

The control of phosphatidylinositol 3,4-bisphosphate concentrations by activation of the Src homology 2 domain containing inositol polyphosphate 5-phosphatase 2, SHIP2

Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

PTEN: The down side of PI 3-kinase signalling

Localization of agonist-sensitive PtdIns(3,4,5)P₃ reveals a nuclear pool that is insensitive to PTEN expression

Interleukin-3-mediated Cell Survival Signals Include Phosphatidylinositol 3-Kinase-dependent Translocation of the Glucose Transporter GLUT1 to the Cell Surface

A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

MyosinV controls PTEN function and neuronal cell size

Detection of novel intracellular agonist responsive pools of phosphatidylinositol 3,4-bisphosphate using the TAPP1 pleckstrin homology domain in immunoelectron microscopy

Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C δ1

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

Muscarinic Receptors Mediate Phospholipase C-dependent Activation of Protein Kinase B via Ca2+, ErbB3, and Phosphoinositide 3-Kinase in 1321N1 Astrocytoma Cells

Differential redox regulation within the PTP superfamily

The Lipid Phosphatase Activity of PTEN is Critical for Its Tumor Supressor Function

The tumour-suppressor function of PTEN requires an N-terminal lipid-binding motif

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