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NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma

Oncogene, 2015-09, Vol.34 (39), p.5069-5079

2015

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Using mice to examine p53 functions in cancer, aging, and longevity

Cold Spring Harbor perspectives in biology, 2009-12, Vol.1 (6), p.a001081-a001081

Donehower, Lawrence A

2009

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Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma

Oncogene, 2010-09, Vol.29 (35), p.4938-4946

2010

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Nature (London), 1995-11, Vol.378 (6553), p.206-208

1995

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Notch signaling contributes to the pathogenesis of human osteosarcomas

Human molecular genetics, 2009-04, Vol.18 (8), p.1464-1470

2009

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p53 in embryonic development: maintaining a fine balance

Cellular and molecular life sciences : CMLS, 1999, Vol.55 (1), p.38-47

1999

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Nature (London), 1992-03, Vol.356 (6366), p.215-221

1992

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Genes & development, 2000-06, Vol.14 (12), p.1448

2000

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Absence of Wip1 partially rescues Atm deficiency phenotypes in mice

Oncogene, 2012-03, Vol.31 (9), p.1155-1165

2012

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Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

Oncogene, 2000-03, Vol.19 (13), p.1635-1646

2000

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Overexpression of Mdm2 in Mice Reveals a p53-Independent Role for Mdm2 in Tumorigenesis

Proceedings of the National Academy of Sciences - PNAS, 1998-12, Vol.95 (26), p.15608-15612

1998

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A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

Nature genetics, 1995-03, Vol.9 (3), p.305-311

1995

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Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

The Journal of neuroscience, 1996-02, Vol.16 (4), p.1337-1345

1996

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Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

The EMBO journal, 1998-08, Vol.17 (16), p.4657-4667

1998

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The p53-deficient mouse: a model for basic and applied cancer studies

Seminars in cancer biology, 1996-10, Vol.7 (5), p.269-278

Donehower, Lawrence A.

1996

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Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

Molecular and Cellular Biology, 1996-07, Vol.16 (7), p.3765-3772

1996

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In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice

Oncogene, 1993-09, Vol.8 (9), p.2457-2467

1993

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The Structure and Expression of the Murine Wildtype p53-Induced Phosphatase 1 (Wip1) Gene

Genomics (San Diego, Calif.), 2000-03, Vol.64 (3), p.298-306

2000

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Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin

Cancer research (Chicago, Ill.), 1995-03, Vol.55 (5), p.1146-1151

1995

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Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Cell reports (Cambridge), 2019-07, Vol.28 (5), p.1370-1384.e5

2019

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Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53+/- Mouse Model in Carcinogenicity Testing

Toxicologic pathology, 2001, Vol.29 (1_suppl), p.147-154

2001

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Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome

Proceedings of the National Academy of Sciences - PNAS, 1993-10, Vol.90 (19), p.9075-9079

1993

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Genetic background alters the spectrum of tumors that develop in p53‐deficient mice

The FASEB journal, 1993-07, Vol.7 (10), p.938-943

1993

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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

Cell, 1993-09, Vol.74 (5), p.813-822

1993

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The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens

Toxicologic pathology, 2001, Vol.29, p.24-29

2001

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NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma

Using mice to examine p53 functions in cancer, aging, and longevity

Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Notch signaling contributes to the pathogenesis of human osteosarcomas

p53 in embryonic development: maintaining a fine balance

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice

Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression

Overexpression of Mdm2 in Mice Reveals a p53-Independent Role for Mdm2 in Tumorigenesis

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

The p53-deficient mouse: a model for basic and applied cancer studies

Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice

The Structure and Expression of the Murine Wildtype p53-Induced Phosphatase 1 (Wip1) Gene

Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Is p53 Haploinsufficient for Tumor Suppression? Implications for the p53+/- Mouse Model in Carcinogenicity Testing

Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome

Genetic background alters the spectrum of tumors that develop in p53‐deficient mice

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens

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